海外医薬品不足状況

• 2025.07.28
  ASHP供給不足情報（2025年7月21日～7月27日）

  Generic Name	Shortage Status	Revision Date
  Phenytoin Oral Suspension	Current Shortages	27-Jul-25
  Pimecrolimus 1% Topical Cream	Current Shortages	27-Jul-25
  Prednisone Oral Tablets	Current Shortages	27-Jul-25
  Insulin Aspart Injection	Current Shortages	25-Jul-25
  Insulin Degludec Injection	Current Shortages	25-Jul-25
  Rifapentine Tablets	Resolved Shortages	25-Jul-25
  Triamcinolone Acetonide Injectable Suspension	Current Shortages	25-Jul-25
  Triamcinolone Hexacetonide Injection	Current Shortages	25-Jul-25
  Octreotide Intramuscular Injection Kits	Current Shortages	23-Jul-25
  3% and 5% Sodium Chloride Large Volume Injection	Resolved Shortages	22-Jul-25
  0.45% Sodium Chloride Injection Bags	Resolved Shortages	22-Jul-25
  0.9% Sodium Chloride Irrigation	Current Shortages	22-Jul-25
  Acetaminophen Injection	Current Shortages	22-Jul-25
  Acetylcysteine Oral and Inhalation Solution	Current Shortages	22-Jul-25
  Adenosine Injection	Current Shortages	22-Jul-25
  Amiodarone Injection	Current Shortages	22-Jul-25
  Azathioprine Sodium Injection	Current Shortages	22-Jul-25
  Cefazolin Injection	Current Shortages	22-Jul-25
  Chlorothiazide Sodium Injection	Current Shortages	22-Jul-25
  Ciprofloxacin Injection	Resolved Shortages	22-Jul-25
  Clindamycin Phosphate Injection	Current Shortages	22-Jul-25
  Moxifloxacin Tablets	Current Shortages	22-Jul-25
  Remifentanil Injection	Current Shortages	22-Jul-25
  Testosterone Cypionate Injection	Current Shortages	22-Jul-25
  Vecuronium Bromide Injection	Current Shortages	22-Jul-25
  Aminocaproic Acid Injection	Current Shortages	21-Jul-25
  Cisplatin Injection	Current Shortages	21-Jul-25
  Dexamethasone Oral Solution/Elixir	Current Shortages	21-Jul-25
  Dexamethasone Sodium Phosphate Injection	Current Shortages	21-Jul-25
  Lisdexamfetamine Dimesylate Capsules	Current Shortages	21-Jul-25
  Nitrofurantoin Oral Suspension	Current Shortages	21-Jul-25
  Scopolamine Transdermal System	Current Shortages	21-Jul-25
  Vasopressin Injection	Current Shortages	21-Jul-25

• 2025.07.28
  FDA供給不足情報：新規・更新（2025年7月21日～7月27日）

  New

  July 24, 2025

  • Glipizide Tablet, Extended Release (Discontinuation)

  July 23, 2025

  • Amantadine Hydrochloride Capsule (Discontinuation)

  • Amantadine Hydrochloride Tablet (Discontinuation)

  • Potassium Chloride Tablet, Extended Release (Discontinuation)

  July 21, 2025

  • Insulin Aspart Injection (Discontinuation)

  • Insulin Aspart Protamine and Insulin Aspart Mix 70/30 Injectable Suspension (Discontinuation)

  • Insulin Degludec Injection (Discontinuation)

   

   

  Updated

  July 24, 2025

  • Amphetamine Aspartate Monohydrate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate Tablet (Currently In Shortage)

  July 23, 2025

  • Amino Acid Injection (Currently In Shortage)

  • Dexamethasone Sodium Phosphate Injection (Currently In Shortage)

  • Dopamine Hydrochloride Injection (Currently In Shortage)

  • Etomidate Injection (Currently In Shortage)

  • Fentanyl Citrate Injection (Currently In Shortage)

  • Hydromorphone Hydrochloride Injection (Currently In Shortage)

  • Ketorolac Tromethamine Injection (Currently In Shortage)

  • Lidocaine Hydrochloride Injection (Currently In Shortage)

  • Lidocaine Hydrochloride Solution (Currently In Shortage)

  • Lorazepam Injection (Currently In Shortage)

  • Meperidine Hydrochloride Injection (Currently In Shortage)

  • Methamphetamine Hydrochloride Tablet (Currently In Shortage)

  • Promethazine Hydrochloride Injection (Currently In Shortage)

  • Sodium Chloride 0.9% Injection (Currently In Shortage)

  • Sufentanil Citrate Injection (Currently In Shortage)

  • Valproate Sodium Injection (Currently In Shortage)

  July 22, 2025

  • Azacitidine Injection (Currently In Shortage)
• 2025.07.21
  ASHP供給不足情報（2025年7月14日～7月20日）

  Generic Name	Shortage Status	Revision Date
  Bacitracin Ophthalmic Ointment	Current Shortages	18-Jul-25
  Dorzolamide Ophthalmic Solution	Current Shortages	18-Jul-25
  Lidocaine Hydrochloride Oral Topical Solution (Viscous) 2%	Current Shortages	18-Jul-25
  Magnesium Citrate Oral Solution	Current Shortages	18-Jul-25
  Penicillin G Benzathine	Current Shortages	18-Jul-25
  Amoxicillin and Clavulanate Oral Presentations	Current Shortages	17-Jul-25
  Dulaglutide Injection	Current Shortages	17-Jul-25
  Flurazepam Capsules	Resolved Shortages	17-Jul-25
  Amiodarone Injection	Current Shortages	16-Jul-25
  Azithromycin Powder for Oral Suspension Packets	Current Shortages	16-Jul-25
  Bacitracin Ophthalmic Ointment	Current Shortages	18-Jul-25
  Dorzolamide Ophthalmic Solution	Current Shortages	18-Jul-25
  Lidocaine Hydrochloride Oral Topical Solution (Viscous) 2%	Current Shortages	18-Jul-25
  Magnesium Citrate Oral Solution	Current Shortages	18-Jul-25
  Penicillin G Benzathine	Current Shortages	18-Jul-25
  Amoxicillin and Clavulanate Oral Presentations	Current Shortages	17-Jul-25
  Dulaglutide Injection	Current Shortages	17-Jul-25
  Flurazepam Capsules	Resolved Shortages	17-Jul-25
  Amiodarone Injection	Current Shortages	16-Jul-25
  Azithromycin Powder for Oral Suspension Packets	Current Shortages	16-Jul-25
  Cisplatin Injection	Current Shortages	16-Jul-25
  Clonazepam Oral Tablets	Current Shortages	16-Jul-25
  Dextroamphetamine Extended-Release Capsules	Current Shortages	16-Jul-25
  Etomidate Injection	Current Shortages	16-Jul-25
  Leucovorin Calcium Injection	Current Shortages	16-Jul-25
  Megestrol Acetate Tablets	Current Shortages	16-Jul-25
  Morphine Oral Solution	Current Shortages	16-Jul-25
  Propranolol Hydrochloride Injection	Current Shortages	16-Jul-25
  Propranolol Hydrochloride Oral Solution	Current Shortages	16-Jul-25
  Vancomycin Hydrochloride Injection	Current Shortages	16-Jul-25
  Bacteriostatic Water for Injection	Current Shortages	15-Jul-25
  Iloprost Inhalation Solution (Ventavis)	Current Shortages	14-Jul-25

• 2025.07.21
  FDA供給不足情報：新規・更新（2025年7月14日～7月20日）

  New

  July 17, 2025

  • Lidocaine Patch (Discontinuation)

  • Oxaprozin Tablet (Discontinuation)

  • Pemetrexed Ditromethamine Injection (Discontinuation)

  • Potassium Citrate Tablet, Extended Release (Discontinuation)

   

  July 16, 2025

  • Ethionamide Tablet (Discontinuation)

   

   

  Updated

  July 18, 2025

  • Lisdexamfetamine Dimesylate Capsule (Currently In Shortage)

  • Lisdexamfetamine Dimesylate Tablet, Chewable (Currently In Shortage)

  • Methylphenidate Hydrochloride Tablet, Extended Release (Currently In Shortage)

  • Naltrexone Hydrochloride Tablet (Currently In Shortage)

   

  July 17, 2025

  • Azacitidine Injection (Currently In Shortage)

  • Bupivacaine Hydrochloride Injection (Currently In Shortage)

  • Dexamethasone Sodium Phosphate Injection (Currently In Shortage)

  • Lidocaine Hydrochloride Injection (Currently In Shortage)

  • Methylprednisolone Acetate Injection (Currently In Shortage)

  • Rocuronium Bromide Injection (Currently In Shortage)

  • Ropivacaine Hydrochloride Injection (Currently In Shortage)

   

  July 16, 2025

  • Amphetamine Aspartate Monohydrate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate Tablet (Currently In Shortage)

  • Dextrose Monohydrate 10% Injection (Currently In Shortage)

  • Dextrose Monohydrate 5% Injection (Currently In Shortage)

  • Dextrose Monohydrate 70% Injection (Currently In Shortage)

  • Heparin Sodium Injection (Currently In Shortage)

  • Hydroxypropyl Cellulose (1600000 Wamw) Insert (Currently In Shortage)

  • Lactated Ringers Injection (Currently In Shortage)

  • Lisdexamfetamine Dimesylate Capsule (Currently In Shortage)

  • Lisdexamfetamine Dimesylate Tablet, Chewable (Currently In Shortage)

  • Methylphenidate Hydrochloride Tablet, Extended Release (Currently In Shortage)

  • Midazolam Hydrochloride Injection (Currently In Shortage)

  • Morphine Sulfate Injection (Currently In Shortage)

  • Sodium Chloride 0.9% Injection (Currently In Shortage)

  • Sterile Water Irrigant (Currently In Shortage)

   

  July 15, 2025

  • Bupivacaine Hydrochloride, Epinephrine Bitartrate Injection (Currently In Shortage)

  • Dexamethasone Sodium Phosphate Injection (Currently In Shortage)

  • Dextrose Monohydrate 10% Injection (Currently In Shortage)

  • Etomidate Injection (Currently In Shortage)

  • Hydromorphone Hydrochloride Injection (Currently In Shortage)

  • Morphine Sulfate Injection (Currently In Shortage)

  • Sodium Bicarbonate Injection (Currently In Shortage)

  • Sodium Chloride 0.9% Injection (Currently In Shortage)

   

  July 14, 2025

  • • Penicillin G Benzathine Injection (Currently In Shortage)
• 2025.07.14
  ASHP供給不足情報（2025年7月7日～7月13日）

  Generic Name	Shortage Status	Revision Date
  Penicillin G Benzathine	Current Shortages	13-Jul-25
  Amoxicillin Oral Presentations	Current Shortages	11-Jul-25
  Budesonide Suspension for Inhalation	Current Shortages	11-Jul-25
  Doxazosin Extended Release Oral Tablets	Current Shortages	11-Jul-25
  Heparin Injection	Current Shortages	11-Jul-25
  Cefotaxime Sodium Injection	Current Shortages	10-Jul-25
  Desmopressin Acetate Nasal Spray	Current Shortages	10-Jul-25
  50% Dextrose Injection	Current Shortages	9-Jul-25
  Docetaxel Injection	Current Shortages	9-Jul-25
  Droperidol Injection	Resolved Shortages	9-Jul-25
  Epinephrine Injection	Current Shortages	9-Jul-25
  Hydroxyethyl Starch (Hetastarch)	Current Shortages	9-Jul-25
  Methylprednisolone Sodium Succinate Injection	Current Shortages	9-Jul-25
  Nalbuphine Injection	Current Shortages	9-Jul-25
  Phenylephrine Ophthalmic Solution	Current Shortages	9-Jul-25
  Quinapril Tablets	Current Shortages	9-Jul-25
  Rocuronium Injection	Current Shortages	9-Jul-25
  Terbutaline Sulfate Injection	Current Shortages	9-Jul-25
  Triamcinolone Hexacetonide Injection	Current Shortages	9-Jul-25
  Amphotericin B Lipid Complex	Current Shortages	8-Jul-25
  Imatinib Mesylate Tablets	Current Shortages	8-Jul-25
  Oxycodone Hydrochloride Immediate-Release Tablets	Current Shortages	7-Jul-25

• 2025.07.14
  FDA供給不足情報：新規・更新（2025年7月7日～7月13日）

  New

  July 10, 2025

  • Levothyroxine Sodium Tablet (Discontinuation)

  July 8, 2025

  • Morphine Sulfate Injection (Discontinuation)

  • Oseltamivir Phosphate Capsule (Discontinuation)

  • Potassium Chloride Tablet, Extended Release (Discontinuation)

   

  Updated

  July 10, 2025

  • Bupivacaine Hydrochloride Injection (Currently In Shortage)

  • Bupivacaine Hydrochloride, Epinephrine Bitartrate Injection (Currently In Shortage)

  • Dobutamine Hydrochloride Injection (Currently In Shortage)

  • Epinephrine Bitartrate, Lidocaine Hydrochloride Injection (Currently In Shortage)

  • Fentanyl Citrate Injection (Currently In Shortage)

  • Hydrocortisone Sodium Succinate Injection (Currently In Shortage)

  • Hydromorphone Hydrochloride Injection (Currently In Shortage)

  • Lidocaine Hydrochloride Injection (Currently In Shortage)

  • Lisdexamfetamine Dimesylate Capsule (Currently In Shortage)

  • Meperidine Hydrochloride Injection (Currently In Shortage)

  • Methotrexate Sodium Injection (Currently In Shortage)

  • Methylprednisolone Acetate Injection (Currently In Shortage)

  • Morphine Sulfate Injection (Currently In Shortage)

  • Penicillin G Benzathine Injection (Currently In Shortage)

  • Rocuronium Bromide Injection (Currently In Shortage)

  • Sodium Bicarbonate Injection (Currently In Shortage)

  • Sufentanil Citrate Injection (Currently In Shortage)

   

  July 9, 2025

  • Amphetamine Aspartate Monohydrate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate Tablet (Currently In Shortage)

   

  July 8, 2025

  • Amphetamine Aspartate Monohydrate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate Tablet (Currently In Shortage)

  • Azacitidine Injection (Currently In Shortage)

  • Carboplatin Injection (Currently In Shortage)

  • Dexmedetomidine Hydrochloride Injection (Currently In Shortage)

  • Hydromorphone Hydrochloride Injection (Currently In Shortage)

  • Leucovorin Calcium Injection (Resolved)

  • Lisdexamfetamine Dimesylate Capsule (Currently In Shortage)

  • Mefloquine Hydrochloride Tablet (Currently In Shortage)

  • Methotrexate Sodium Injection (Currently In Shortage)

  • Methylphenidate Hydrochloride Tablet, Extended Release (Currently In Shortage)

  • Streptozocin Powder, For Solution (Currently In Shortage)

   

  July 7, 2025

  • Carboplatin Injection (Currently In Shortage)

  • Lisdexamfetamine Dimesylate Capsule (Currently In Shortage)

  • Lisdexamfetamine Dimesylate Tablet, Chewable (Currently In Shortage)

  • Methylphenidate Hydrochloride Tablet, Extended Release (Currently In Shortage)

  • Naltrexone Hydrochloride Tablet (Currently In Shortage)

  • Peritoneal Dialysis Solution (Resolved)

  • Rocuronium Bromide Injection (Currently In Shortage)

  • Technetium TC-99M Pyrophosphate Kit Injection (Currently In Shortage)
• 2025.07.07
  ASHP供給不足情報（2025年6月30日～7月6日）

  Generic Name	Shortage Status	Revision Date
  Dexmethylphenidate Extended Release Capsules	Current Shortages	3-Jul-25
  Methylphenidate Immediate-Release Tablets	Current Shortages	3-Jul-25
  Triamcinolone Acetonide Injectable Suspension	Current Shortages	3-Jul-25
  Ciprofloxacin Injection	Current Shortages	1-Jul-25
  Clindamycin Phosphate Injection	Current Shortages	1-Jul-25
  Dextran Low Molecular Weight (Dextran 40), 10% Injection	Current Shortages	1-Jul-25
  Fluconazole Injection	Resolved Shortages	1-Jul-25
  Hydrocortisone Sodium Succinate Injection	Current Shortages	1-Jul-25
  Ribavirin Inhalation	Current Shortages	1-Jul-25
  Testosterone Cypionate Injection	Current Shortages	1-Jul-25
  Adenosine Injection	Current Shortages	30-Jun-25
  Aminocaproic Acid Injection	Current Shortages	30-Jun-25
  Atropine Sulfate Injection	Current Shortages	30-Jun-25
  Ephedrine Injection	Current Shortages	30-Jun-25
  Erythromycin Lactobionate Injection	Current Shortages	30-Jun-25
  Gentamicin Injection	Current Shortages	30-Jun-25
  Lorazepam Injection	Current Shortages	30-Jun-25
  Rho(D) Immune Globulin (Human)	Current Shortages	30-Jun-25
  Vasopressin Injection	Current Shortages	30-Jun-25

• 2025.07.07
  FDA供給不足情報：新規・更新（2025年6月30日～7月6日）

  New

  July 1, 2025

  • Isoniazid Tablet (Discontinuation)

   

  Updated

  July 3, 2025

  • Lorazepam Injection (Currently In Shortage)

  • Oxazepam Capsule (Resolved)

  • Remifentanil Hydrochloride Injection (Currently In Shortage)

  • Rifampin Injection (Currently In Shortage)

   

  July 2, 2025

  • Albuterol Sulfate Solution (Currently In Shortage)

  • Amino Acid Injection (Currently In Shortage)

  • Bacitracin Ophthalmic Ointment (Currently In Shortage)

  • Dopamine Hydrochloride Injection (Currently In Shortage)

  • Sodium Chloride 0.9% Irrigation (Resolved)

  • Sodium Chloride 23.4% Injection (Resolved)

   

  July 1, 2025

  • Dextrose Monohydrate 10% Injection (Currently In Shortage)

  • Propranolol Hydrochloride Injection (Currently In Shortage)

  • Remifentanil Hydrochloride Injection (Currently In Shortage)

  • Sodium Chloride 0.9% Injection (Currently In Shortage)

  • Valproate Sodium Injection (Currently In Shortage)

   

  June 30, 2025

  • Clindamycin Phosphate Injection (Currently In Shortage)

  • Dobutamine Hydrochloride Injection (Currently In Shortage)

  • Dopamine Hydrochloride Injection (Currently In Shortage)

  • Furosemide Injection (Currently In Shortage)

  • Hydrocortisone Sodium Succinate Injection (Currently In Shortage)

  • Lorazepam Injection (Currently In Shortage)

  • Methylprednisolone Acetate Injection (Currently In Shortage)

  • Midazolam Hydrochloride Injection (Currently In Shortage)

  • Rocuronium Bromide Injection (Currently In Shortage)

  • Sterile Water Injection (Currently In Shortage)

  • Streptozocin Powder, For Solution (Currently In Shortage)

カナダの情報はありません。

• 2025.07.28
  TGAオーストラリア供給不足情報（2025年7月21日～7月27日）

  Active ingredients	Dosage form	Quantity of active ingredients	Shortage status	Availability	Reason	Last updated
  flecainide acetate	Injection, solution	10 mg/mL	Current	Unavailable	Manufacturing	25/07/2025
  lidocaine hydrochloride	Injection, solution	10 mg/mL	Current	Unavailable	Manufacturing	25/07/2025
  medronic acid	Injection, powder for	10 mg	Current	Unavailable	Manufacturing	25/07/2025
  venlafaxine hydrochloride	Capsule, modified release	169.71 mg	Current	Unavailable	Unexpected increase in demand due to other sponsors unable to supply	25/07/2025
  doxorubicin hydrochloride	Injection, concentrated	2 mg/mL	Current	Limited Availability	Manufacturing	25/07/2025
  live varicella vaccine	Injection, powder for	4000 PFU/mL	Current	Only available under NIP or government programs	Unexpected increase in demand due to other sponsors unable to supply	25/07/2025
  fluorouracil	Injection, solution	50 mg/mL	Current	Limited Availability	Unexpected increase in consumer demand	25/07/2025
  teriflunomide	Tablet, film coated	14 mg	Current	Limited Availability	Manufacturing	25/07/2025
  adrenaline (epinephrine)	Injection, solution	500 microgram	Current	Unavailable	Manufacturing	25/07/2025
  GluureaLys(ahx)hbedCC	Injection, powder for	25 microgram	Anticipated	Available	Manufacturing	25/07/2025
  avatrombopag maleate	Tablet, film coated	23.6 mg	Current	Limited Availability	Manufacturing	25/07/2025
  ramipril	Tablet, uncoated	1.25 mg	Current	Limited Availability	Transport / Logistic issues / Storage capacity issues	25/07/2025
  trandolapril	Capsule, hard	2 mg	Current	Limited Availability	Manufacturing	25/07/2025
  tobramycin	Injection, solution	40 mg/mL	Discontinued	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	25/07/2025
  nizatidine	Capsule	150 mg	Current	Limited Availability	Manufacturing	25/07/2025
  galantamine hydrobromide~galantamine	Capsule, modified release	20.51 mg~16 mg	Current	Unavailable	Unexpected increase in demand due to other sponsors unable to supply	25/07/2025
  dexamethasone~framycetin sulfate~gramicidin	Ear Drops	.5 mg/mL~5 mg/mL~.05 mg/mL	Current	Unavailable	Manufacturing	24/07/2025
  mirtazapine	Tablet, film coated	45 mg	Resolved	Available	Manufacturing	24/07/2025
  pioglitazone hydrochloride	Tablet	16.63 mg	Anticipated	Available	Manufacturing	24/07/2025
  ropivacaine hydrochloride	Injection, solution	40 mg	Current	Limited Availability	Transport / Logistic issues / Storage capacity issues	24/07/2025
  ezetimibe~rosuvastatin calcium	Tablet~Tablet, film coated	10 mg~41.583 mg	Current	Limited Availability	Manufacturing	24/07/2025
  isotretinoin	Capsule, soft	10 mg	Anticipated	Available	Manufacturing	24/07/2025
  Influenza virus haemagglutinin	Injection, suspension	15 microgram	Resolved	Available	Seasonal depletion of stock	24/07/2025
  solifenacin succinate	Tablet, film coated	10 mg	Resolved	Available	Manufacturing	24/07/2025
  lacosamide	Tablet, film coated	200 mg	Current	Unavailable	Manufacturing	24/07/2025
  larotrectinib sulfate	Capsule, hard	30.7 mg	Current	Limited Availability	Unexpected increase in consumer demand	24/07/2025
  rivaroxaban	Tablet, film coated	20 mg	Resolved	Available	Manufacturing	24/07/2025
  oxaliplatin	Injection, concentrated	100 mg	Current	Limited Availability	Manufacturing	24/07/2025
  GluureaLys(ahx)hbedCC	Injection, powder for	25 microgram	Resolved	Available	Manufacturing	24/07/2025
  metformin hydrochloride~sitagliptin hydrochloride monohydrate	Tablet, modified release	1000 mg~113.37 mg	Resolved	Available	Manufacturing	24/07/2025
  sitagliptin hydrochloride monohydrate~metformin hydrochloride	Tablet, modified release	56.685 mg~1000 mg	Resolved	Available	Manufacturing	24/07/2025
  levothyroxine sodium	Tablet	200 microgram	Current	Unavailable	Unexpected increase in consumer demand	24/07/2025
  ethosuximide	Capsule, soft	250 mg	Resolved	Available	Manufacturing	24/07/2025
  framycetin sulfate	Eye and Ear Drops	5 mg/mL	Current	Limited Availability	Transport / Logistic issues / Storage capacity issues	24/07/2025
  ropivacaine hydrochloride	Injection, solution	7.5 mg/mL	Current	Unavailable	Unexpected increase in consumer demand	24/07/2025
  ropivacaine hydrochloride	Injection, solution	2 mg/mL	Current	Limited Availability	Unexpected increase in demand due to other sponsors unable to supply	24/07/2025
  spironolactone	Tablet, film coated	25 mg	Current	Unavailable	Unexpected increase in demand due to other sponsors unable to supply	24/07/2025
  pioglitazone hydrochloride	Tablet, uncoated	49.59 mg	Anticipated	Available	Commercial Changes / Commercial viability	24/07/2025
  clopidogrel hydrogen sulfate	Tablet, film coated	97.875 mg	Current	Limited Availability	Unexpected increase in demand due to other sponsors unable to supply	24/07/2025
  metformin hydrochloride	Tablet, film coated	1000 mg	Resolved	Available	Manufacturing	24/07/2025
  benzathine benzylpenicillin tetrahydrate	Injection, suspension	1200000 USP Unit	Current	Unavailable	Manufacturing	23/07/2025
  tramadol hydrochloride	Tablet, modified release	200 mg	Anticipated	Available	Manufacturing	23/07/2025
  pioglitazone hydrochloride	Tablet, uncoated	49.59 mg	Current	Unavailable	Manufacturing	23/07/2025
  pioglitazone hydrochloride	Tablet, uncoated	33.06 mg	Current	Unavailable	Manufacturing	23/07/2025
  pioglitazone hydrochloride	Tablet, uncoated	16.53 mg	Current	Unavailable	Manufacturing	23/07/2025
  aripiprazole	Tablet, uncoated	10 mg	Resolved	Available	Manufacturing	23/07/2025
  tramadol hydrochloride	Tablet, modified release	200 mg	Resolved	Available	Manufacturing	23/07/2025
  entecavir	Tablet, film coated	.5 mg	Current	Unavailable	Manufacturing	23/07/2025
  hydrocortisone	Tablet, uncoated	4 mg	Current	Limited Availability	Manufacturing	23/07/2025
  atorvastatin calcium trihydrate~ezetimibe	Tablet, film coated	10.341 mg~10 mg	Current	Unavailable	Manufacturing	23/07/2025
  sertraline hydrochloride	Tablet, film coated	56 mg	Current	Limited Availability	Manufacturing	23/07/2025
  sertraline hydrochloride	Tablet, film coated	112 mg	Current	Limited Availability	Manufacturing	23/07/2025
  midazolam	Injection, solution	5 mg/mL	Current	Limited Availability	Manufacturing	22/07/2025
  sodium pyrophosphate	Injection, powder for	30 mg	Current	Unavailable	Manufacturing	22/07/2025
  trimethoprim~sulfamethoxazole	Injection, concentrated	16 mg/mL~80 mg/mL	Current	Limited Availability	Manufacturing	22/07/2025
  indapamide hemihydrate~perindopril erbumine	Tablet	1.25 mg~4 mg	Current	Unavailable	Manufacturing	22/07/2025
  Pneumococcal purified capsular polysaccharides	Injection, solution	50 microgram/mL	Current	Only available under NIP or government programs	Unexpected increase in consumer demand	22/07/2025
  metformin hydrochloride	Tablet, film coated	1000 mg	Current	Limited Availability	Manufacturing	22/07/2025
  bleomycin sulfate	Injection, powder for	15000 IU	Anticipated	Available	Manufacturing	22/07/2025
  dexamethasone~framycetin sulfate~gramicidin	Ear Drops	.5 mg/mL~5 mg/mL~.05 mg/mL	Current	Limited Availability	Manufacturing	22/07/2025
  flecainide acetate	Tablet, uncoated	100 mg	Current	Unavailable	Manufacturing	22/07/2025
  fluorouracil	Injection, solution	50 mg/mL	Current	Limited Availability	Unexpected increase in consumer demand	22/07/2025
  omega3acid ethyl esters 90	Capsule, soft	1000 mg	Discontinued	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	21/07/2025
  naloxone hydrochloride dihydrate~buprenorphine hydrochloride	Soluble Film	2.44 mg~8.64 mg	Resolved	Available	Transport / Logistic issues / Storage capacity issues	21/07/2025
  mycophenolate mofetil	Capsule	250 mg	Current	Limited Availability	Manufacturing	21/07/2025
  montelukast sodium	Tablet, film coated	10.4 mg	Current	Unavailable	Manufacturing	21/07/2025
  montelukast sodium	Tablet, chewable	4.16 mg	Current	Unavailable	Manufacturing	21/07/2025
  montelukast sodium	Tablet, chewable	5.2 mg	Current	Unavailable	Manufacturing	21/07/2025
  sildenafil citrate	Tablet, film coated	28.1 mg	Current	Unavailable	Manufacturing	21/07/2025
  finasteride	Tablet, film coated	1 mg	Current	Limited Availability	Manufacturing	21/07/2025
  candesartan cilexetil	Tablet, uncoated	16 mg	Resolved	Available	Manufacturing	21/07/2025
  ondansetron	Tablet, orally disintegrating	8 mg	Anticipated	Available	Manufacturing	21/07/2025
  irbesartan~hydrochlorothiazide	Tablet, film coated	300 mg~12.5 mg	Current	Unavailable	Manufacturing	21/07/2025
  irbesartan~hydrochlorothiazide	Tablet, film coated	300 mg~12.5 mg	Current	Unavailable	Manufacturing	21/07/2025
  hydrochlorothiazide~irbesartan	Tablet, film coated	25 mg~300 mg	Current	Unavailable	Manufacturing	21/07/2025
  nizatidine	Capsule, hard	150 mg	Current	Unavailable	Manufacturing	21/07/2025
  nitisinone	Tablet	10 mg	Resolved	Available	Manufacturing	21/07/2025
  nitisinone	Tablet	5 mg	Resolved	Available	Manufacturing	21/07/2025
  olanzapine	Tablet, uncoated	5 mg	Resolved	Available	Manufacturing	21/07/2025
  sitagliptin hydrochloride monohydrate	Tablet, film coated	56.69 mg	Resolved	Available	Manufacturing	21/07/2025
  methylphenidate hydrochloride	Tablet, modified release	36 mg	Resolved	Available	Unexpected increase in demand due to other sponsors unable to supply	21/07/2025
  levothyroxine sodium	Tablet	75 microgram	Current	Unavailable	Manufacturing	21/07/2025
  heparin sodium	Injection, solution	5000 IU	Anticipated	Available	Transport / Logistic issues / Storage capacity issues	21/07/2025
  tamoxifen citrate	Tablet, uncoated	30.4 mg	Resolved	Available	Commercial Changes / Commercial viability	21/07/2025
  sirolimus	Oral Liquid, solution	1 mg/mL	Anticipated	Available	Manufacturing	21/07/2025
  methylphenidate hydrochloride	Capsule, modified release	20 mg	Anticipated	Available	Manufacturing	21/07/2025

• 2025.07.21
  TGAオーストラリア供給不足情報（2025年7月14日～7月20日）

  Active ingredients	Dosage form	Quantity of active ingredients	Shortage status	Availability	Reason	Last updated
  gentamicin	Injection, solution	80 mg	Resolved	Available	Manufacturing	20/07/2025
  GluureaLys(ahx)hbedCC	Injection, powder for	25 microgram	Anticipated	Available	Manufacturing	20/07/2025
  GluureaLys(ahx)hbedCC	Injection, powder for	25 microgram	Anticipated	Available	Manufacturing	20/07/2025
  propranolol hydrochloride	Tablet, film coated	10 mg	Anticipated	Available	Manufacturing	18/07/2025
  propranolol hydrochloride	Tablet, film coated	40 mg	Anticipated	Available	Manufacturing	18/07/2025
  glimepiride	Tablet, uncoated	1 mg	Anticipated	Available	Manufacturing	18/07/2025
  lamotrigine	Tablet, chewable	100 mg	Current	Limited Availability	Manufacturing	18/07/2025
  fentanyl	Drug delivery system, transdermal	16.8 mg	Anticipated	Available	Unexpected increase in demand due to other sponsors unable to supply	18/07/2025
  losartan potassium	Tablet, film coated	25 mg	Current	Unavailable	Manufacturing	18/07/2025
  pramipexole dihydrochloride monohydrate	Tablet	.25 mg	Current	Unavailable	Manufacturing	18/07/2025
  metronidazole	Tablet, uncoated	400 mg	Current	Limited Availability	Manufacturing	18/07/2025
  risedronate sodium hemipentahydrate	Tablet, film coated	173.4 mg	Resolved	Available	Manufacturing	18/07/2025
  indapamide hemihydrate	Tablet, sugar coated	2.5 mg	Anticipated	Available	Manufacturing	18/07/2025
  acarbose	Tablet	100 mg	Anticipated	Available	Manufacturing	18/07/2025
  pramipexole dihydrochloride monohydrate	Tablet	.125 mg	Current	Limited Availability	Unexpected increase in consumer demand	18/07/2025
  citalopram hydrobromide	Tablet, film coated	49.98 mg	Anticipated	Available	Manufacturing	18/07/2025
  irbesartan	Tablet, film coated	300 mg	Current	Limited Availability	Manufacturing	18/07/2025
  acamprosate calcium	Tablet, enteric coated	333 mg	Current	Limited Availability	Manufacturing	18/07/2025
  risperidone	Oral Liquid, solution	1 mg/mL	Current	Limited Availability	Manufacturing	18/07/2025
  Semaglutide	Injection, solution	1.34 mg/mL	Discontinued	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	18/07/2025
  Semaglutide	Injection, solution	1.34 mg/mL	Resolved	Available	Unexpected increase in consumer demand	18/07/2025
  naloxone hydrochloride dihydrate	Injection	440 microgram	Anticipated	Available	Unexpected increase in consumer demand	18/07/2025
  lamotrigine	Tablet, chewable	200 mg	Current	Limited Availability	Manufacturing	18/07/2025
  valsartan~sacubitril	Tablet, film coated	51.4 mg~48.6 mg	Current	Unavailable	Manufacturing	18/07/2025
  valsartan~sacubitril	Tablet, film coated	25.7 mg~24.3 mg	Current	Unavailable	Manufacturing	18/07/2025
  sacubitril~valsartan	Tablet, film coated	97.2 mg~102.8 mg	Current	Unavailable	Manufacturing	18/07/2025
  lanreotide acetate	Injection, solution	133.33 mg	Current	Limited Availability	Manufacturing	18/07/2025
  Semaglutide	Injection, solution	.68 mg/mL	Resolved	Available	Unexpected increase in consumer demand	18/07/2025
  Mycobacterium bovis (Bacillus Calmette and Guerin (BCG) strain)	Injection, powder for	200000000 CFU	Current	Limited Availability	Unexpected increase in consumer demand	18/07/2025
  alprostadil	Injection, powder for	20 microgram/mL	Current	Unavailable	Unexpected increase in consumer demand	18/07/2025
  alprostadil	Injection, powder for	40 microgram/mL	Current	Unavailable	Manufacturing	18/07/2025
  sertraline hydrochloride	Tablet, film coated	56 mg	Current	Limited Availability	Manufacturing	18/07/2025
  Epoetin beta	Injection	6666.66 IU/mL	Discontinued	Reduction in supply until supply is exhausted	Transport / Logistic issues / Storage capacity issues	17/07/2025
  Epoetin beta	Injection	10000 IU/mL	Discontinued	Reduction in supply until supply is exhausted	Transport / Logistic issues / Storage capacity issues	17/07/2025
  Epoetin beta	Injection	13333.33 IU/mL	Discontinued	Reduction in supply until supply is exhausted	Transport / Logistic issues / Storage capacity issues	17/07/2025
  Epoetin beta	Injection	16666.67 IU/mL	Discontinued	Reduction in supply until supply is exhausted	Transport / Logistic issues / Storage capacity issues	17/07/2025
  Epoetin beta	Injection	20000 IU/mL	Discontinued	Reduction in supply until supply is exhausted	Transport / Logistic issues / Storage capacity issues	17/07/2025
  Epoetin beta	Injection	16666.67 IU/mL	Discontinued	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	17/07/2025
  live varicella vaccine~Measles virus~Rubella virus~Mumps virus	Injection, powder for	1995 PFU~1000 CCID50~1000 CCID50~25119 CCID50	Resolved	Available	Manufacturing	17/07/2025
  bupivacaine hydrochloride monohydrate	Injection, solution	52.7 mg	Current	Limited Availability	Manufacturing	17/07/2025
  tramadol hydrochloride	Capsule	50 mg	Discontinued	Unavailable	Manufacturing	17/07/2025
  tramadol hydrochloride	Capsule	50 mg	Anticipated	Available	Manufacturing	17/07/2025
  methylphenidate hydrochloride	Tablet, modified release	27 mg	Current	Limited Availability	Manufacturing	17/07/2025
  ondansetron hydrochloride dihydrate	Injection, solution	5 mg	Current	Limited Availability	Manufacturing	17/07/2025
  olanzapine	Tablet, orally disintegrating	20 mg	Current	Limited Availability	Manufacturing	17/07/2025
  midazolam	Injection, solution	5 mg	Current	Limited Availability	Manufacturing	17/07/2025
  sildenafil citrate	Tablet, film coated	140.45 mg	Anticipated	Available	Unexpected increase in demand due to other sponsors unable to supply	17/07/2025
  pramipexole dihydrochloride monohydrate	Tablet	1 mg	Current	Unavailable	Manufacturing	17/07/2025
  pramipexole dihydrochloride monohydrate	Tablet	.125 mg	Current	Unavailable	Manufacturing	17/07/2025
  olanzapine	Tablet, orally disintegrating	5 mg	Current	Limited Availability	Manufacturing	17/07/2025
  trimethoprim~sulfamethoxazole	Tablet, uncoated	80 mg~400 mg	Resolved	Available	Manufacturing	17/07/2025
  sulfamethoxazole~trimethoprim	Tablet, uncoated	800 mg~160 mg	Anticipated	Available	Manufacturing	17/07/2025
  indapamide hemihydrate~perindopril erbumine	Tablet	1.25 mg~4 mg	Current	Limited Availability	Manufacturing	17/07/2025
  montelukast sodium	Tablet, chewable	5.2 mg	Current	Unavailable	Unexpected increase in consumer demand	17/07/2025
  montelukast sodium	Tablet, film coated	10.4 mg	Resolved	Available	Manufacturing	17/07/2025
  clopidogrel hydrogen sulfate	Tablet, film coated	97.875 mg	Current	Limited Availability	Unexpected increase in demand due to other sponsors unable to supply	17/07/2025
  sumatriptan succinate	Tablet, film coated	69.99 mg	Anticipated	Available	Manufacturing	17/07/2025
  ciprofloxacin hydrochloride	Tablet, film coated	277.5 mg	Current	Unavailable	Manufacturing	17/07/2025
  ciprofloxacin hydrochloride	Tablet, film coated	832.5 mg	Current	Unavailable	Manufacturing	17/07/2025
  ropivacaine hydrochloride	Injection, solution	150 mg	Current	Limited Availability	Transport / Logistic issues / Storage capacity issues	17/07/2025
  amlodipine besilate~atorvastatin calcium trihydrate	Tablet, film coated	6.94 mg~43.376 mg	Current	Unavailable	Manufacturing	17/07/2025
  phenoxymethylpenicillin potassium	Tablet, film coated	560 mg	Anticipated	Available	Manufacturing	17/07/2025
  ezetimibe~simvastatin	Tablet	10 mg~10 mg	Current	Limited Availability	Manufacturing	17/07/2025
  capecitabine	Tablet, film coated	500 mg	Current	Limited Availability	Unexpected increase in consumer demand	17/07/2025
  lansoprazole	Tablet, orally disintegrating	30 mg	Anticipated	Available	Manufacturing	17/07/2025
  esomeprazole	Capsule, enteric	20 mg	Current	Unavailable	Manufacturing	17/07/2025
  naproxen	Tablet, modified release	750 mg	Anticipated	Available	Manufacturing	17/07/2025
  ezetimibe	Tablet, uncoated	10 mg	Anticipated	Available	Unexpected increase in consumer demand	17/07/2025
  solifenacin succinate	Tablet	10 mg	Current	Limited Availability	Manufacturing	17/07/2025
  tranexamic acid	Tablet, film coated	500 mg	Current	Limited Availability	Manufacturing	17/07/2025
  hydrocortisone	Tablet, uncoated	4 mg	Current	Limited Availability	Manufacturing	17/07/2025
  deferasirox	Tablet, film coated	90 mg	Current	Limited Availability	Manufacturing	17/07/2025
  deferasirox	Tablet, film coated	360 mg	Anticipated	Available	Manufacturing	17/07/2025
  atorvastatin calcium trihydrate	Tablet, film coated	43.376 mg	Current	Limited Availability	Manufacturing	17/07/2025
  atorvastatin calcium trihydrate	Tablet, film coated	43.376 mg	Current	Limited Availability	Manufacturing	17/07/2025
  flecainide acetate	Tablet	50 mg	Current	Limited Availability	Manufacturing	17/07/2025
  chloramphenicol	Eye Drops, solution	5 mg/mL	Current	Unavailable	Manufacturing	17/07/2025
  paracetamol	Tablet, modified release	665 mg	Current	Limited Availability	Transport / Logistic issues / Storage capacity issues	17/07/2025
  dacarbazine	Injection, powder for	200 mg	Resolved	Available	Manufacturing	17/07/2025
  trandolapril	Capsule, hard	2 mg	Current	Limited Availability	Manufacturing	17/07/2025
  labetalol hydrochloride	Tablet, film coated	100 mg	Anticipated	Available	Manufacturing	17/07/2025
  dalteparin sodium	Injection, solution	15000 anti-Xa IU	Discontinued	Unavailable	Commercial Changes / Commercial viability	17/07/2025
  methylphenidate hydrochloride	Tablet, modified release	18 mg	Current	Limited Availability	Manufacturing	17/07/2025
  methylphenidate hydrochloride	Tablet, modified release	36 mg	Current	Limited Availability	Manufacturing	17/07/2025
  methylphenidate hydrochloride	Tablet, modified release	54 mg	Current	Limited Availability	Manufacturing	17/07/2025
  tranexamic acid	Injection, solution	1000 mg	Current	Unavailable	Manufacturing	16/07/2025
  ciclesonide	Spray, nasal	50 microgram/actuation	Resolved	Available	Transport / Logistic issues / Storage capacity issues	16/07/2025
  mycophenolate mofetil	Capsule	250 mg	Current	Limited Availability	Manufacturing	16/07/2025
  pramipexole dihydrochloride monohydrate	Tablet	.25 mg	Current	Unavailable	Transport / Logistic issues / Storage capacity issues	16/07/2025
  isotretinoin	Capsule, soft	20 mg	Current	Limited Availability	Manufacturing	16/07/2025
  ropivacaine hydrochloride	Injection, solution	40 mg	Anticipated	Available	Transport / Logistic issues / Storage capacity issues	16/07/2025
  atorvastatin calcium trihydrate~amlodipine besilate	Tablet, film coated	10.844 mg~13.88 mg	Current	Limited Availability	Manufacturing	16/07/2025
  midazolam	Injection, solution	5 mg	Resolved	Available	Manufacturing	16/07/2025
  oxytocin	Injection, solution	5 IU/mL	Current	Limited Availability	Unexpected increase in consumer demand	16/07/2025
  oxytocin	Injection, solution	10 IU/mL	Current	Limited Availability	Manufacturing	16/07/2025
  methotrexate	Injection, solution	100 mg/mL	Resolved	Available	Manufacturing	16/07/2025
  rifampicin	Capsule	150 mg	Current	Emergency Supply Only	Manufacturing	16/07/2025
  irbesartan~hydrochlorothiazide	Tablet, film coated	150 mg~12.5 mg	Current	Limited Availability	Manufacturing	16/07/2025
  celecoxib	Capsule, hard	100 mg	Current	Unavailable	Manufacturing	16/07/2025
  spironolactone	Tablet, uncoated	25 mg	Current	Limited Availability	Manufacturing	16/07/2025
  phentermine hydrochloride	Tablet, modified release	18.6375 mg	Discontinued	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	16/07/2025
  phentermine hydrochloride	Tablet, modified release	37.275 mg	Discontinued	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	16/07/2025
  phentermine hydrochloride	Tablet, modified release	49.7 mg	Discontinued	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	16/07/2025
  levothyroxine sodium	Tablet, uncoated	.05 mg	Resolved	Available	Manufacturing	16/07/2025
  levothyroxine sodium	Tablet, uncoated	.075 mg	Resolved	Available	Manufacturing	16/07/2025
  avatrombopag maleate	Tablet, film coated	23.6 mg	Current	Limited Availability	Manufacturing	16/07/2025
  lidocaine hydrochloride	Injection, solution	20 mg/mL	Resolved	Available	Manufacturing	16/07/2025
  rifabutin	Capsule, hard	150 mg	Resolved	Available	Manufacturing	16/07/2025
  zolpidem tartrate	Tablet, film coated	10 mg	Resolved	Available	Transport / Logistic issues / Storage capacity issues	16/07/2025
  olanzapine	Injection, powder for	10 mg	Current	Limited Availability	Unexpected increase in consumer demand	16/07/2025
  clopidogrel hydrogen sulfate	Tablet, film coated	97.875 mg	Anticipated	Available	Unexpected increase in demand due to other sponsors unable to supply	16/07/2025
  sodium lactate~icodextrin~calcium chloride dihydrate~magnesium chloride hexahydrate~sodium chloride	Solution, dialysis	4.5 g/L~75 g/L~257 mg/L~51 mg/L~5.4 g/L	Current	Limited Availability	Manufacturing	16/07/2025
  Peginterferon alfa2a	Injection, solution	135 microgram	Current	Unavailable	Unexpected increase in consumer demand	16/07/2025
  citalopram hydrobromide	Tablet, film coated	49.96 mg	Current	Unavailable	Manufacturing	16/07/2025
  clopidogrel hydrogen sulfate	Tablet, film coated	97.875 mg	Current	Emergency Supply Only	Unexpected increase in demand due to other sponsors unable to supply	15/07/2025
  olanzapine	Tablet, film coated	5 mg	Resolved	Available	Manufacturing	15/07/2025
  mirtazapine	Tablet, film coated	45 mg	Current	Unavailable	Manufacturing	15/07/2025
  phenobarbital sodium	Injection, solution	219 mg/mL	Current	Unavailable	Manufacturing	15/07/2025
  propranolol hydrochloride	Tablet, film coated	40 mg	Current	Unavailable	Manufacturing	15/07/2025
  prucalopride succinate	Tablet, film coated	2.642 mg	Resolved	Available	Transport / Logistic issues / Storage capacity issues	15/07/2025
  Vespula spp venom	Injection, powder for	550 microgram	Resolved	Available	Manufacturing	15/07/2025
  bicalutamide~leuprorelin acetate	Injection, modified release~Tablet, film coated	50 mg~22.5 mg	Discontinued	Unavailable	Commercial Changes / Commercial viability	15/07/2025
  bicalutamide~leuprorelin acetate	Injection, modified release~Tablet, film coated	50 mg~22.5 mg	Discontinued	Unavailable	Commercial Changes / Commercial viability	15/07/2025
  hydromorphone hydrochloride	Injection, solution	2 mg/mL	Discontinued	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	15/07/2025
  cyproterone acetate	Tablet, uncoated	50 mg	Current	Limited Availability	Manufacturing	15/07/2025
  amiodarone hydrochloride	Tablet, uncoated	100 mg	Current	Limited Availability	Manufacturing	15/07/2025
  tamoxifen citrate	Tablet, uncoated	15.2 mg	Current	Unavailable	Manufacturing	15/07/2025
  tamoxifen citrate	Tablet, uncoated	30.4 mg	Current	Unavailable	Manufacturing	15/07/2025
  naproxen	Tablet, uncoated	250 mg	Current	Unavailable	Manufacturing	15/07/2025
  flecainide acetate	Tablet, uncoated	100 mg	Current	Unavailable	Manufacturing	15/07/2025
  betiatide	Injection, powder for	1 mg	Current	Emergency Supply Only	Manufacturing	14/07/2025
  verapamil hydrochloride	Tablet, modified release	240 mg	Resolved	Available	Manufacturing	14/07/2025
  fludarabine phosphate	Injection, powder for	50 mg	Current	Unavailable	Manufacturing	14/07/2025
  honey bee venom	Injection, powder for	550 microgram	Resolved	Available	Manufacturing	14/07/2025
  pramipexole dihydrochloride monohydrate	Tablet	.125 mg	Current	Unavailable	Manufacturing	14/07/2025
  ondansetron hydrochloride dihydrate	Tablet, film coated	9.972 mg	Anticipated	Available	Manufacturing	14/07/2025
  galantamine hydrobromide	Capsule, modified release	10.252 mg	Current	Unavailable	Manufacturing	14/07/2025
  galantamine hydrobromide	Capsule, modified release	30.756 mg	Current	Unavailable	Manufacturing	14/07/2025
  galantamine hydrobromide	Capsule, modified release	20.504 mg	Current	Unavailable	Manufacturing	14/07/2025
  candesartan cilexetil	Tablet, uncoated	32 mg	Resolved	Available	Manufacturing	14/07/2025
  linezolid	Tablet, film coated	600 mg	Current	Unavailable	Manufacturing	14/07/2025
  solifenacin succinate	Tablet	5 mg	Resolved	Available	Manufacturing	14/07/2025
  nizatidine	Capsule, hard	150 mg	Current	Unavailable	Manufacturing	14/07/2025
  rasagiline mesilate	Tablet	1.56 mg	Anticipated	Available	Manufacturing	14/07/2025
  ceftazidime pentahydrate~avibactam sodium	Injection, powder for	2329.7 mg~543.5 mg	Current	Limited Availability	Unexpected increase in consumer demand	14/07/2025
  estradiol~estradiol~norethisterone acetate	Drug delivery system, transdermal	.512 mg~.78 mg~4.8 mg	Resolved	Available	Manufacturing	14/07/2025
  icatibant acetate	Injection, solution	31.38 mg	Current	Limited Availability	Manufacturing	14/07/2025
  Teriparatide	Injection, solution	250 microgram/mL	Anticipated	Available	Manufacturing	14/07/2025
  Tiger snake antivenom	Injection, concentrated	3000 U	Current	Emergency Supply Only	Manufacturing	14/07/2025
  metformin hydrochloride	Tablet, film coated	1000 mg	Current	Unavailable	Manufacturing	14/07/2025

• 2025.07.14
  TGAオーストラリア供給不足情報（2025年7月7日～7月13日）

  Active ingredients	Dosage form	Quantity of active ingredients	Availability	Reason	Last updated
  valaciclovir	Tablet, film coated	500 mg	Limited Availability	Manufacturing	11/07/2025
  losartan potassium	Tablet, film coated	50 mg	Limited Availability	Manufacturing	11/07/2025
  losartan potassium	Tablet, film coated	25 mg	Limited Availability	Manufacturing	11/07/2025
  risperidone	Tablet, film coated	2 mg	Available	Manufacturing	11/07/2025
  pioglitazone hydrochloride	Tablet	16.63 mg	Available	Manufacturing	11/07/2025
  risedronate sodium hemipentahydrate	Tablet, film coated	173.4 mg	Limited Availability	Manufacturing	11/07/2025
  phenobarbital	Tablet, uncoated	30 mg	Available	Manufacturing	11/07/2025
  quetiapine fumarate	Tablet, modified release	57.565 mg	Available	Unexpected increase in consumer demand	11/07/2025
  bosentan monohydrate	Tablet, film coated	129.082 mg	Limited Availability	Manufacturing	11/07/2025
  pemetrexed disodium	Injection, powder for	110.28 mg	Unavailable	Manufacturing	11/07/2025
  pemetrexed disodium	Injection, powder for	1102.8 mg	Unavailable	Manufacturing	11/07/2025
  citalopram hydrobromide	Tablet, film coated	12.495 mg	Limited Availability	Manufacturing	11/07/2025
  daptomycin	Injection, powder for	350 mg	Available	Manufacturing	11/07/2025
  sodium lactate~icodextrin~calcium chloride dihydrate~magnesium chloride hexahydrate~sodium chloride	Solution, dialysis	4.5 g/L~75 g/L~257 mg/L~51 mg/L~5.4 g/L	Limited Availability	Manufacturing	11/07/2025
  methylphenidate hydrochloride	Tablet, uncoated	10 mg	Available	Manufacturing	10/07/2025
  ethinylestradiol~dienogest	Tablet, sugar coated	.03 mg~2 mg	Available	Commercial Changes / Commercial viability	10/07/2025
  fludarabine phosphate	Injection, powder for	50 mg	Unavailable	Manufacturing	10/07/2025
  montelukast sodium	Tablet, chewable	4.16 mg	Limited Availability	Manufacturing	10/07/2025
  montelukast sodium	Tablet, film coated	10.4 mg	Available	Manufacturing	10/07/2025
  clopidogrel hydrogen sulfate	Tablet, film coated	97.875 mg	Limited Availability	Unexpected increase in consumer demand	10/07/2025
  tramadol hydrochloride	Tablet, modified release	200 mg	Limited Availability	Manufacturing	10/07/2025
  anastrozole	Tablet, film coated	1 mg	Available	Manufacturing	10/07/2025
  cefuroxime axetil	Tablet, film coated	300.715 mg	Available	Manufacturing	10/07/2025
  pegaspargase	Solution, powder for	750 U/mL	Available	Manufacturing	10/07/2025
  atorvastatin calcium trihydrate~ezetimibe	Tablet, film coated	41.363 mg~10 mg	Available	Manufacturing	10/07/2025
  dimethyl fumarate	Capsule, enteric	120 mg	Unavailable	Manufacturing	10/07/2025
  lurasidone hydrochloride	Tablet, film coated	40 mg	Unavailable	Manufacturing	10/07/2025
  Albumin	Injection	.3 mg/mL	Unavailable	Manufacturing	10/07/2025
  midazolam maleate	Solution	10.2 mg	Limited Availability	Manufacturing	10/07/2025
  rosuvastatin calcium~ezetimibe	Tablet~Tablet, film coated	41.6 mg~10 mg	Limited Availability	Manufacturing	10/07/2025
  Peginterferon alfa2a	Injection, solution	135 microgram	Limited Availability	Unexpected increase in consumer demand	10/07/2025
  Peginterferon alfa2a	Injection, solution	180 microgram	Unavailable	Unexpected increase in consumer demand	10/07/2025
  olanzapine pamoate monohydrate	Injection, powder for	483 mg	Limited Availability	Transport / Logistic issues / Storage capacity issues	9/07/2025
  methotrexate	Tablet, uncoated	2.5 mg	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	9/07/2025
  artemether~lumefantrine	Tablet, dispersible	20 mg~120 mg	Unavailable	Commercial Changes / Commercial viability	9/07/2025
  riluzole	Tablet, film coated	50 mg	Limited Availability	Manufacturing	9/07/2025
  ondansetron	Tablet, orally disintegrating	8 mg	Available	Manufacturing	9/07/2025
  betamethasone dipropionate~calcipotriol	Foam	264 microgram/g~20.5 microgram/g	Limited Availability	Transport / Logistic issues / Storage capacity issues	9/07/2025
  atorvastatin calcium trihydrate	Tablet, film coated	86.76 mg	Unavailable	Manufacturing	9/07/2025
  fluorouracil	Injection, solution	50 mg/mL	Unavailable	Manufacturing	9/07/2025
  paclitaxel	Injection, powder for	100 mg	Limited Availability	Manufacturing	9/07/2025
  desvenlafaxine	Tablet, modified release	100 mg	Available	Manufacturing	9/07/2025
  permethrin	Cream	50 mg/g	Limited Availability	Commercial Changes / Commercial viability	9/07/2025
  galantamine~galantamine hydrobromide	Capsule, modified release	16 mg~20.51 mg	Available	Unexpected increase in demand due to other sponsors unable to supply	9/07/2025
  zolpidem tartrate	Tablet, film coated	10 mg	Available	Unexpected increase in consumer demand	8/07/2025
  morphine sulfate pentahydrate	Tablet, modified release	10 mg	Unavailable	Manufacturing	8/07/2025
  morphine sulfate pentahydrate	Tablet, modified release	30 mg	Unavailable	Manufacturing	8/07/2025
  morphine sulfate pentahydrate	Tablet, modified release	60 mg	Unavailable	Manufacturing	8/07/2025
  morphine sulfate pentahydrate	Tablet, modified release	100 mg	Unavailable	Manufacturing	8/07/2025
  amiodarone hydrochloride	Injection, solution	150 mg	Available	Unexpected increase in demand due to other sponsors unable to supply	8/07/2025
  indapamide hemihydrate	Tablet, sugar coated	2.5 mg	Available	Manufacturing	8/07/2025
  nicorandil	Tablet	10 mg	Unavailable	Manufacturing	8/07/2025
  paclitaxel	Injection, concentrated	300 mg	Limited Availability	Manufacturing	8/07/2025
  calcipotriol~betamethasone dipropionate	Ointment	52.2 microgram/g~643 microgram/g	Available	Manufacturing	8/07/2025
  sodium valproate	Injection, solution	400 mg	Available	Manufacturing	8/07/2025
  estradiol~estradiol~norethisterone acetate	Drug delivery system, transdermal	.78 mg~.62 mg~2.7 mg	Unavailable	Manufacturing	8/07/2025
  levothyroxine sodium	Tablet	75 microgram	Unavailable	Manufacturing	8/07/2025
  prazosin hydrochloride	Tablet, uncoated	5.5 mg	Unavailable	Manufacturing	8/07/2025
  prucalopride succinate	Tablet, film coated	2.642 mg	Unavailable	Transport / Logistic issues / Storage capacity issues	7/07/2025
  galantamine hydrobromide	Capsule, modified release	20.504 mg	Unavailable	Manufacturing	7/07/2025
  galantamine hydrobromide	Capsule, modified release	30.756 mg	Unavailable	Manufacturing	7/07/2025
  deoxycholic acid	Injection, solution	10 mg/mL	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	7/07/2025
  ezetimibe	Tablet, uncoated	10 mg	Unavailable	Unexpected increase in consumer demand	7/07/2025
  nicorandil	Tablet, uncoated	10 mg	Limited Availability	Manufacturing	7/07/2025
  nitisinone	Tablet	10 mg	Unavailable	Manufacturing	7/07/2025
  nitisinone	Tablet	5 mg	Limited Availability	Manufacturing	7/07/2025
  avatrombopag maleate	Tablet, film coated	23.6 mg	Available	Manufacturing	7/07/2025

• 2025.07.07
  TGAオーストラリア供給不足情報（2025年6月30日～7月6日）

  Active ingredients	Dosage form	Quantity of active ingredients	Shortage status	Availability	Reason	Last updated
  larotrectinib sulfate	Capsule, hard	30.7 mg	Anticipated	Available	Unexpected increase in consumer demand	6/07/2025
  benzathine benzylpenicillin tetrahydrate	Injection, suspension	1200000 USP Unit	Current	Unavailable	Manufacturing	4/07/2025
  levetiracetam	Tablet, film coated	500 mg	Anticipated	Available	Manufacturing	4/07/2025
  metronidazole	Tablet, uncoated	400 mg	Current	Unavailable	Manufacturing	4/07/2025
  galantamine hydrobromide	Capsule, modified release	30.756 mg	Current	Limited Availability	Manufacturing	4/07/2025
  quetiapine fumarate	Tablet, modified release	460.52 mg	Current	Limited Availability	Manufacturing	4/07/2025
  irbesartan~hydrochlorothiazide	Tablet, film coated	300 mg~12.5 mg	Current	Unavailable	Manufacturing	4/07/2025
  acarbose	Tablet	100 mg	Anticipated	Available	Manufacturing	4/07/2025
  irbesartan	Tablet, film coated	150 mg	Current	Limited Availability	Manufacturing	4/07/2025
  ivabradine hydrochloride	Tablet, film coated	8.085 mg	Current	Unavailable	Manufacturing	4/07/2025
  ivabradine hydrochloride	Tablet, film coated	5.39 mg	Current	Unavailable	Manufacturing	4/07/2025
  flucloxacillin sodium monohydrate	Injection, powder for	544.1 mg	Current	Limited Availability	Transport / Logistic issues / Storage capacity issues	4/07/2025
  sitagliptin hydrochloride monohydrate	Tablet, film coated	56.69 mg	Current	Unavailable	Manufacturing	4/07/2025
  daptomycin	Injection, powder for	500 mg	Resolved	Available	Manufacturing	4/07/2025
  dacarbazine	Injection, powder for	200 mg	Current	Limited Availability	Manufacturing	4/07/2025
  spironolactone	Tablet, film coated	100 mg	Resolved	Available	Manufacturing	4/07/2025
  pioglitazone hydrochloride	Tablet, uncoated	16.53 mg	Current	Unavailable	Commercial Changes / Commercial viability	4/07/2025
  lidocaine hydrochloride	Injection, solution	10 mg/mL	Anticipated	Available	Manufacturing	3/07/2025
  venlafaxine hydrochloride	Capsule, modified release	169.71 mg	Current	Unavailable	Unexpected increase in demand due to other sponsors unable to supply	3/07/2025
  risperidone	Tablet, film coated	2 mg	Anticipated	Available	Manufacturing	3/07/2025
  naloxone hydrochloride dihydrate~buprenorphine hydrochloride	Soluble Film	2.44 mg~8.64 mg	Anticipated	Available	Transport / Logistic issues / Storage capacity issues	3/07/2025
  ezetimibe~rosuvastatin calcium	Tablet~Tablet, film coated	10 mg~41.583 mg	Current	Limited Availability	Manufacturing	3/07/2025
  bosentan monohydrate	Tablet, film coated	129.082 mg	Anticipated	Available	Manufacturing	3/07/2025
  midazolam	Injection, solution	15 mg	Resolved	Available	Manufacturing	3/07/2025
  ezetimibe~atorvastatin calcium trihydrate	Tablet, multilayer	10 mg~86.8 mg	Resolved	Available	Manufacturing	3/07/2025
  isotretinoin	Capsule, soft	10 mg	Anticipated	Available	Manufacturing	3/07/2025
  tranexamic acid	Tablet, film coated	500 mg	Anticipated	Available	Manufacturing	3/07/2025
  encorafenib	Capsule, hard	50 mg	Current	Limited Availability	Manufacturing	3/07/2025
  midodrine hydrochloride	Tablet	5 mg	Current	Unavailable	Manufacturing	3/07/2025
  erlotinib hydrochloride	Tablet, film coated	27.32 mg	Anticipated	Available	Unexpected increase in consumer demand	3/07/2025
  levothyroxine sodium	Tablet	.2 mg	Resolved	Available	Manufacturing	3/07/2025
  rosuvastatin calcium	Tablet, film coated	41.68 mg	Resolved	Available	Manufacturing	3/07/2025
  sildenafil citrate	Tablet, film coated	70.24 mg	Current	Unavailable	Unexpected increase in consumer demand	3/07/2025
  fentanyl citrate	Injection, solution	785 microgram	Current	Unavailable	Manufacturing	3/07/2025
  cytarabine	Injection, solution	100 mg/mL	Resolved	Available	Manufacturing	3/07/2025
  lidocaine hydrochloride	Injection, solution	10 mg/mL	Resolved	Available	Manufacturing	3/07/2025
  lidocaine hydrochloride monohydrate	Injection, solution	20 mg/mL	Anticipated	Available	Manufacturing	3/07/2025
  lidocaine hydrochloride monohydrate	Injection, solution	10 mg/mL	Current	Unavailable	Manufacturing	3/07/2025
  lidocaine hydrochloride monohydrate	Injection, solution	10 mg/mL	Current	Limited Availability	Manufacturing	3/07/2025
  losartan potassium	Tablet, film coated	50 mg	Resolved	Available	Unexpected increase in consumer demand	3/07/2025
  zolpidem tartrate	Tablet, film coated	10 mg	Current	Limited Availability	Transport / Logistic issues / Storage capacity issues	3/07/2025
  Rubella virus~live varicella vaccine~Mumps virus~Measles virus	Injection, powder for	1000 CCID50~1995 PFU~25119 CCID50~1000 CCID50	Current	Unavailable	Manufacturing	2/07/2025
  zolpidem tartrate	Tablet, film coated	10 mg	Resolved	Available	Manufacturing	2/07/2025
  acetylcholine chloride	Solution, powder for irrigation	10 mg/mL	Current	Unavailable	Manufacturing	2/07/2025
  metformin hydrochloride	Tablet, film coated	500 mg	Current	Unavailable	Manufacturing	2/07/2025
  metformin hydrochloride	Tablet, film coated	500 mg	Current	Unavailable	Manufacturing	2/07/2025
  sulfamethoxazole~trimethoprim	Injection, concentrated	80 mg/mL~16 mg/mL	Current	Limited Availability	Manufacturing	2/07/2025
  busulfan	Injection, concentrated	60 mg	Resolved	Available	Manufacturing	2/07/2025
  ceftazidime pentahydrate~avibactam sodium	Injection, powder for	2329.7 mg~543.5 mg	Anticipated	Available	Unexpected increase in consumer demand	2/07/2025
  teriflunomide	Tablet, film coated	14 mg	Current	Unavailable	Manufacturing	2/07/2025
  levothyroxine sodium	Tablet, uncoated	.05 mg	Current	Limited Availability	Manufacturing	2/07/2025
  levothyroxine sodium	Tablet, uncoated	.075 mg	Current	Limited Availability	Manufacturing	2/07/2025
  verapamil hydrochloride	Tablet, modified release	240 mg	Current	Limited Availability	Manufacturing	1/07/2025
  ciprofloxacin hydrochloride	Tablet, film coated	555 mg	Current	Unavailable	Manufacturing	1/07/2025
  ropivacaine hydrochloride	Injection, solution	150 mg	Resolved	Available	Transport / Logistic issues / Storage capacity issues	1/07/2025
  nicorandil	Tablet	20 mg	Current	Limited Availability	Manufacturing	1/07/2025
  nicorandil	Tablet	10 mg	Current	Unavailable	Manufacturing	1/07/2025
  leuprorelin acetate~bicalutamide	Injection, modified release~Tablet, film coated	22.5 mg~50 mg	Discontinued	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	1/07/2025
  mesalazine	Tablet, enteric coated	250 mg	Current	Unavailable	Manufacturing	1/07/2025
  metformin hydrochloride	Tablet, film coated	1000 mg	Current	Limited Availability	Manufacturing	1/07/2025
  trimethoprim	Tablet, uncoated	300 mg	Resolved	Available	Manufacturing	1/07/2025
  pomalidomide	Capsule, hard	2 mg	Current	Unavailable	Manufacturing	1/07/2025
  carbidopa monohydrate~levodopa	Tablet, uncoated	26.9 mg~100 mg	Resolved	Available	Manufacturing	1/07/2025
  estradiol~norethisterone acetate	Drug delivery system, transdermal	.62 mg~2.7 mg	Resolved	Available	Manufacturing	1/07/2025
  norethisterone acetate~estradiol	Drug delivery system, transdermal	4.8 mg~.512 mg	Resolved	Available	Manufacturing	1/07/2025
  minocycline hydrochloride dihydrate	Tablet, film coated	54 mg	Resolved	Available	Manufacturing	1/07/2025
  estradiol hemihydrate	Drug delivery system, transdermal	2.32 mg	Current	Limited Availability	Unexpected increase in demand due to other sponsors unable to supply	1/07/2025
  methylphenidate hydrochloride	Capsule, modified release	20 mg	Anticipated	Available	Manufacturing	1/07/2025
  nizatidine	Capsule	150 mg	Current	Limited Availability	Manufacturing	1/07/2025
  live varicella vaccine	Injection, powder for	2700 PFU/mL	Current	Limited Availability	Unexpected increase in demand due to other sponsors unable to supply	30/06/2025
  pentetic acid	Injection, powder for	5 mg	Current	Unavailable	Manufacturing	30/06/2025
  medronic acid	Injection, powder for	10 mg	Current	Unavailable	Manufacturing	30/06/2025
  sodium fluoride	Injection, concentrated	1 mg/mL	Current	Unavailable	Manufacturing	30/06/2025
  ciprofloxacin hydrochloride	Tablet, film coated	277.5 mg	Current	Unavailable	Manufacturing	30/06/2025
  ciprofloxacin hydrochloride	Tablet, film coated	832.5 mg	Current	Unavailable	Manufacturing	30/06/2025
  midazolam	Injection, solution	5 mg	Current	Unavailable	Manufacturing	30/06/2025
  tranexamic acid	Injection, solution	1000 mg	Current	Unavailable	Commercial Changes / Commercial viability	30/06/2025
  deoxycholic acid	Injection, solution	10 mg/mL	Discontinued	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	30/06/2025
  voriconazole	Injection, powder for	200 mg	Current	Unavailable	Commercial Changes / Commercial viability	30/06/2025
  solifenacin succinate	Tablet	5 mg	Current	Limited Availability	Manufacturing	30/06/2025
  oxycodone hydrochloride	Injection, solution	10 mg/mL	Current	Unavailable	Commercial Changes / Commercial viability	30/06/2025
  amikacin sulfate	Injection, solution	333.76 mg/mL	Current	Unavailable	Manufacturing	30/06/2025
  ezetimibe~atorvastatin calcium trihydrate	Tablet, film coated	10 mg~20.681 mg	Resolved	Available	Manufacturing	30/06/2025
  paclitaxel	Injection, powder for	100 mg	Current	Limited Availability	Manufacturing	30/06/2025
  finasteride	Tablet, film coated	1 mg	Anticipated	Available	Manufacturing	30/06/2025
  adapalene	Gel	1 mg/g	Resolved	Available	Manufacturing	30/06/2025
  Teriparatide	Injection, solution	250 microgram/mL	Anticipated	Available	Manufacturing	30/06/2025

• 2025.07.28
  BfArMボトルネック・レポート（2025年7月21日～7月27日）

  Active ingredients	Report type	Date of last message	Type of reason	AM designation
  Duloxetine hydrochloride	Change notification	25.07.2025	Production problem	Duloxetine PUREN 60 mg gastro-resistant hard capsules
  Chorionic gonadotropin	Initial report	25.07.2025	Other	BREVACTID 1500 I.E. Powder and solvent for solution for injection
  Human insulin (with manufacturing details)	Initial report	25.07.2025	Other	Berlinsulin H Normal 3 ml pen
  Betamethasone valerate (Ph.Eur.)	Initial report	25.07.2025	Other	Soderm crinale
  Azacitidine	Initial report	25.07.2025	Other	Azacitidine HEXAL 25 mg/ml powder for suspension for injection
  Minocycline hydrochloride dihydrate (Ph.Eur.)	Initial report	25.07.2025	Production problem	Skid 100 mg
  Minocycline hydrochloride dihydrate (Ph.Eur.)	Initial report	25.07.2025	Production problem	Skid 50 mg
  Galantamine hydrobromide	Initial report	24.07.2025	Other	Galanaxiro 24 mg hard capsules, delayed release
  Galantamine hydrobromide	Initial report	24.07.2025	Other	Galanaxiro 16 mg Hard capsules, delayed release
  Galantamine hydrobromide	Initial report	24.07.2025	Other	Galanaxiro 8 mg hard capsules, delayed release
  Lorazepam	Change notification	24.07.2025	Other	Tavor 1.0 mg Expidet
  Carbamazepine	Change notification	24.07.2025	Other	Carbamazepine AL 400 delayed release
  Methylphenidate hydrochloride	Change notification	24.07.2025	Other	Methylphenidate AL 18 mg prolonged-release tablets
  Tacrolimus monohydrate	Change notification	24.07.2025	Other	Tacrolimus AL 5 mg hard capsules, delayed release
  Tacrolimus monohydrate	Change notification	24.07.2025	Other	Tacrolimus AL 1 mg hard capsules, delayed release
  Tacrolimus monohydrate	Change notification	24.07.2025	Other	Tacrolimus AL 0.5 mg hard capsules, delayed release
  Tacrolimus monohydrate	Change notification	24.07.2025	Other	Tacrolimus AL 3 mg hard capsules, delayed release
  Duloxetine hydrochloride	Change notification	24.07.2025	Other	Duloxetine AL 120 mg gastro-resistant hard capsules
  Quetiapine fumarate (Ph.Eur.)	Change notification	24.07.2025	Other	Quetiapine AL 100 mg film-coated tablets
  Selegiline hydrochloride	Initial report	24.07.2025	Other	Selegiline AL 10
  Selegiline hydrochloride	Change notification	24.07.2025	Other	Selegiline AL 5
  Ribavirin	Change notification	24.07.2025	Other	Ribavirin-ratiopharm 400 mg film-coated tablets
  Insulin aspart	Initial report	23.07.2025	Other	NovoRapid 100 E/ml solution for injection in vial – OP[5x(1x10ml)]
  Paliperidone palmitate	Change notification	23.07.2025	Other	Paliperidone AL 25 mg depot injection suspension in a pre-filled syringe
  Azithromycin dihydrate	Initial report	23.07.2025	Other	Azithromycin AL 250 mg film-coated tablets
  Insulin lispro	Initial report	22.07.2025	Other	Liprolog 100 E/ml solution for injection in vial – OP[5x(1x10ml)]
  Trandolapril; verapamil hydrochloride	Change notification	22.07.2025	Production problem	Tarka 240 mg/2 mg tablets with modified release
  Zoledronic acid monohydrate	Change notification	22.07.2025	Other	Zole – 1 A Pharma 5 mg/100 ml infusion solution
  Trimipramine mesylate	Change notification	22.07.2025	Other	Trimipramine – 1 A Pharma 40 mg/ml oral drops, solution
  Pramipexole dihydrochloride monohydrate	Change notification	22.07.2025	Other	Pramipexole HEXAL 0.52 mg prolonged-release tablets
  Cyclophosphamide monohydrate	Change notification	22.07.2025	Other	Cyclophosphamide HEXAL 2000 mg
  Chlortalidone	Change notification	22.07.2025	Other	Chlortalidone HEXAL 50 mg tablets
  Semaglutide	Change notification	22.07.2025	Other	Ozempic 1 mg injection solution in a pre-filled pen – OP(3x3ml)
  Chlortalidone	Change notification	22.07.2025	Other	Chlortalidone HEXAL 25 mg tablets
  Atomoxetine hydrochloride	Change notification	22.07.2025	Other	Atomoxe – 1 A Pharma 80 mg hard capsules
  Atomoxetine hydrochloride	Change notification	22.07.2025	Other	Atomoxe – 1 A Pharma 60 mg hard capsules
  Atomoxetine hydrochloride	Change notification	22.07.2025	Other	Atomoxe – 1 A Pharma 40 mg hard capsules
  Atomoxetine hydrochloride	Change notification	22.07.2025	Other	Atomoxe – 1 A Pharma 25 mg hard capsules
  Atomoxetine hydrochloride	Change notification	22.07.2025	Other	Atomoxe – 1 A Pharma 18 mg hard capsules
  Atomoxetine hydrochloride	Change notification	22.07.2025	Other	Atomoxe – 1 A Pharma 100 mg hard capsules
  Atomoxetine hydrochloride	Change notification	22.07.2025	Other	Atomoxe – 1 A Pharma 10 mg hard capsules
  Urapidil	Initial report	21.07.2025	Other	Ebrantil 30 mg
  Lidocaine	Initial report	21.07.2025	Production problem	XYLOCAIN PUMP SPRAY
  Salbutamol sulfate	Change notification	21.07.2025	Other	Bronchospray novo
  Quetiapine fumarate (Ph.Eur.)	Change notification	21.07.2025	Production problem	Quetiapine Heumann retard 150 mg prolonged-release tablets
  Quetiapine fumarate (Ph.Eur.)	Change notification	21.07.2025	Production problem	Quetiapine Heumann retard 400 mg prolonged-release tablets
  Quetiapine fumarate (Ph.Eur.)	Change notification	21.07.2025	Production problem	Quetiapine Heumann retard 50 mg prolonged-release tablets
  Quetiapine fumarate (Ph.Eur.)	Change notification	21.07.2025	Production problem	Quetiapine Heumann retard 200 mg prolonged-release tablets
  Quetiapine fumarate (Ph.Eur.)	Change notification	21.07.2025	Production problem	Quetiapine Heumann retard 300 mg prolonged-release tablets
  Flunisolid hemihydrate	Change notification	21.07.2025	Other	Syntaris
  Framycetin sulfate (Ph.Eur.)	Change notification	21.07.2025	Other	Leukase N ointment
  Fluorouracil	Change notification	21.07.2025	Other	Fluorouracil Hikma 50 mg/ml solution for injection

• 2025.07.21
  BfArMボトルネック・レポート（2025年7月14日～7月20日）

  Active ingredients	Message type	Date of last message	Type of reason	AM designation
  Olanzapine	Initial report	18.07.2025	Production problem	Zyprexa 7.5 mg coated tablets – OP70 (blister pack)
  Olanzapine embonate monohydrate	Initial report	18.07.2025	Production problem	ZYPADHERA 405 mg powder and solvent for the preparation of a depot injection suspension – OP(931mg+3ml)
  Olanzapine embonate monohydrate	Change notification	18.07.2025	Production problem	ZYPADHERA 300 mg powder and solvent for the preparation of a depot injection suspension – OP(690mg+3ml)
  Levetiracetam	Initial report	18.07.2025	Other	Levetiracetam UCB
  Iron(III) sodium D-gluconate hydroxide oxide complex (approx. 2:1:1:x:y)	Change notification	18.07.2025	Other	Ferrlecit 62.5 mg
  Zoledronic acid monohydrate	Change notification	17.07.2025	Production problem	Zoledronic acid Mylan 4 mg/5 ml concentrate for solution for infusion – OP[4x(4x5ml)]
  Zoledronic acid monohydrate	Change notification	17.07.2025	Production problem	Zoledronic acid Mylan 4 mg/5 ml concentrate for solution for infusion – OP5ml
  Paliperidone palmitate	Change notification	17.07.2025	Other	Paliperidone AL 25 mg depot injection suspension in a pre-filled syringe
  Tacrolimus monohydrate	Change notification	17.07.2025	Other	Tacrolimus AL 3 mg hard capsules, delayed release
  Epoetin beta	Initial report	17.07.2025	Other	NeoRecormon 4000 IU injection solution in pre-filled syringe – OP6
  Duloxetine hydrochloride	Change notification	17.07.2025	Production problem	Duloxetine PUREN 40 mg gastro-resistant hard capsules
  Carbamazepine	Initial report	17.07.2025	Other	Carbadura 400 mg retard
  Tobramycin	Initial report	17.07.2025	Production problem	TOBI Podhaler 28 mg hard capsules with powder for inhalation – OP224(4×56)
  Etoposide	Change notification	16.07.2025	Production problem	Eto-Gry 20 mg/ml concentrate for solution for infusion
  Amantadine hemisulfate	Change notification	16.07.2025	Other	PK-Merz Infusion
  Clopidogrel besylate	Initial report	16.07.2025	Other	Clopidogrel Denk 75 mg film-coated tablets
  Amlodipine besylate; perindopril tert-butylamine	Initial report	16.07.2025	Other	Perindopril/amlodipine Denk 8 mg/10 mg tablets
  Amlodipine besylate; perindopril tert-butylamine	Initial report	16.07.2025	Other	Perindopril/amlodipine Denk 4 mg/10 mg tablets
  Amlodipine besylate; perindopril tert-butylamine	Initial report	16.07.2025	Other	Perindopril/amlodipine Denk 4 mg/5 mg tablets
  Methylphenidate hydrochloride	Change notification	16.07.2025	Other	Methylphenidate AL 18 mg prolonged-release tablets
  Methylphenidate hydrochloride	Change notification	16.07.2025	Other	Methylphenidate AL 27 mg prolonged-release tablets
  	Initial report	16.07.2025	Production problem	Teceos
  Methylphenidate hydrochloride	Change notification	15.07.2025	Other	METHYLPHENI TAD 20 mg tablets
  Methylphenidate hydrochloride	Change notification	15.07.2025	Other	METHYLPHENI TAD 5 mg tablets
  Methylphenidate hydrochloride	Change notification	15.07.2025	Other	METHYLPHENI TAD 10 mg tablets
  Semaglutide	Change notification	15.07.2025	Other	Ozempic 1 mg injection solution in a pre-filled pen – OP(3x3ml)
  Rifampicin	Initial report	15.07.2025	Production problem	EREMFAT 450 mg
  Methyldopa (Ph.Eur.)	Initial report	15.07.2025	Other	Dopegyt tablets
  Aprepitant	Change notification	15.07.2025	Production problem	Aprepitant beta 125 mg and 80 mg hard capsules
  Atomoxetine hydrochloride	Change notification	15.07.2025	Production problem	Atomoxetine beta 80 mg hard capsules
  Olanzapine embonate monohydrate	Change notification	15.07.2025	Production problem	ZYPADHERA 210 mg powder and solvent for the preparation of a depot injection suspension – OP(483mg+3ml)
  Cinacalcet hydrochloride	Change notification	15.07.2025	Other	Cinacalcet Mylan 60 mg film-coated tablets – OP(28×1)
  Trandolapril; verapamil hydrochloride	Change notification	15.07.2025	Other	Tarka 180 mg/ 2 mg modified-release tablets
  Quetiapine fumarate (Ph.Eur.)	Change notification	15.07.2025	Other	Seroquel Prolong 50 mg prolonged-release tablets
  Quetiapine fumarate (Ph.Eur.)	Change notification	15.07.2025	Other	Seroquel Prolong 300 mg prolonged-release tablets
  Norepinephrine hydrochloride/noradrenaline hydrochloride	Change notification	14.07.2025	Production problem	Arterenol 1 ml
  Epinephrine hydrochloride	Change notification	14.07.2025	Production problem	Suprarenin ampoules
  Sodium iodide ((123)I)	Initial report	14.07.2025	Other	Sodium iodide (I 123) injection DRN 5375
  Iobenguan ((123)I)	Initial report	14.07.2025	Other	MIBG (I123) injection DRN 5379
  Quetiapine fumarate (Ph.Eur.)	Initial report	14.07.2025	Production problem	Quetiapine Accord 300 mg prolonged-release tablets
  Quetiapine fumarate (Ph.Eur.)	Initial report	14.07.2025	Production problem	Quetiapine Accord 50 mg prolonged-release tablets
  Midodrine hydrochloride	Change notification	14.07.2025	Other	Gutron tablets
  Insulin lispro	Initial report	14.07.2025	Other	Humalog Mix25 KwikPen 100 E/ml injection suspension – OP (5x3ml)
  Carbamazepine	Initial report	14.07.2025	Other	Carbamazepine-ratiopharm 400 mg prolonged-release tablets
  Carbamazepine	Initial report	14.07.2025	Other	Carbamazepine-ratiopharm 200 mg prolonged-release tablets
  Flucloxacillin sodium 1 H<2>O	Change notification	14.07.2025	Production problem	Staphylex 250 mg capsules
  Sodium (methylprednisolone-21-succinate)	Change notification	14.07.2025	Other	Urbason solubile forte 1000 mg

• 2025.07.14
  BfArMボトルネック・レポート（2025年7月7日～7月13日）

  Active ingredients	Report type	Date of last message	Type of reason	AM designation
  Methyl (5-amino-4-oxopentanoate) hydrochloride	Initial report	11.07.2025	Other	Metvix 160 mg/g cream
  Semaglutide	Initial report	11.07.2025	Other	Ozempic 1 mg injection solution in a pre-filled pen – OP(3x3ml)
  Salbutamol sulfate	Change notification	11.07.2025	Other	Sultanol inhalation solution
  Salbutamol sulfate	Change notification	11.07.2025	Other	Sultanol metered aerosol
  Flunisolid hemihydrate	Change notification	11.07.2025	Other	Syntaris
  Framycetin sulfate (Ph.Eur.)	Change notification	11.07.2025	Other	Leukase N ointment
  Human insulin (with manufacturing details); Isophane insulin suspension for injection (Ph.Eur.)	Initial report	11.07.2025	Other	Actraphane 30 FlexPen 100 IU/ml injection suspension in injector – OP(10x3ml)
  Insulin aspart	Initial report	11.07.2025	Other	NovoMix 30 FlexPen 100 IU/ml injection suspension in pre-filled syringe – OP(10x3ml)
  Promethazine hydrochloride	Initial report	11.07.2025	Production problem	Atosil injection solution N
  Paliperidone palmitate	Initial report	11.07.2025	Other	XEPLION 50 mg depot injection suspension – OP1ml
  Paliperidone palmitate	Initial report	11.07.2025	Other	XEPLION 25 mg depot injection suspension – OP1ml
  Ampicillin sodium	Initial report	10.07.2025	Production problem	Ampicillin Eberth 1 g powder for solution for injection/infusion
  Trometamol	Initial report	10.07.2025	Other	Tham-Köhler
  Trometamol	Initial report	10.07.2025	Other	THAM-Köhler 3 M
  Atorvastatin calcium trihydrate (Ph.Eur.)	Change notification	10.07.2025	Other	Atorvastatin Aristo 60 mg film-coated tablets
  Cinacalcet hydrochloride	Initial report	10.07.2025	Other	Cinacalcet Mylan 60 mg film-coated tablets – OP(28×1)
  Pramipexole dihydrochloride monohydrate	Change notification	10.07.2025	Other	Pramipexole Mylan 0.52 mg prolonged-release tablets
  Pramipexole dihydrochloride monohydrate	Change notification	10.07.2025	Other	Pramipexole Mylan 0.26 mg prolonged-release tablets
  Trandolapril; verapamil hydrochloride	Change notification	10.07.2025	Production problem	Tarka 240 mg/2 mg modified-release tablets
  Sufentanil citrate	Initial report	10.07.2025	Production problem	Sufenta 50 micrograms/ml solution for injection
  Deferasirox	Change notification	10.07.2025	Other	Deferasirox Mylan 180 mg film-coated tablets
  Potassium canrenoate	Change notification	10.07.2025	Production problem	Aldactone 10 ml Canrenoate
  Oxazepam	Change notification	10.07.2025	Other	Oxazepam AL 10
  Amoxicillin trihydrate	Change notification	10.07.2025	Other	Amoxicillin AL TS
  Isophane insulin suspension for injection (Ph.Eur.)	Change notification	09.07.2025	Other	Protaphane FlexPen 100 IU/ml injection suspension in injector – OP (10x3ml)
  Estriol	Initial report	09.07.2025	Other	Ovestin 1 mg cream
  Propofol	Initial report	09.07.2025	Other	DISOPRIVAN 1%
  Lidocaine hydrochloride monohydrate	Initial report	09.07.2025	Other	Xylocaine Gel 2%
  Azathioprine	Initial report	09.07.2025	Other	Imurek 25 mg film-coated tablets
  Levothyroxine sodium (Ph.Eur.)	Initial report	09.07.2025	Other	Thevier 100
  Levothyroxine sodium (Ph.Eur.)	Initial report	09.07.2025	Other	Thevier 50
  Methylphenidate hydrochloride	Initial report	09.07.2025	Other	Methylphenidate-ratiopharm 20 mg modified-release hard capsules
  Methylphenidate hydrochloride	Initial report	09.07.2025	Other	Methylphenidate-ratiopharm 40 mg hard capsules with modified release
  Methyldopa (Ph.Eur.)	Initial report	08.07.2025	Production problem	Presinol 125
  Methyldopa (Ph.Eur.)	Initial report	08.07.2025	Production problem	Presinol 500
  Velmanase alfa	Initial report	08.07.2025	Other	Lamzede 10 mg powder for solution for infusion – OP(10×250,815mg)
  Doxepine hydrochloride (Ph.Eur.)	Change notification	08.07.2025	Production problem	Doxepin 25 Holsten
  Desflurane	Initial report	08.07.2025	Production problem	Suprane
  Carbamazepine	Initial report	08.07.2025	Other	Carbamazepine AL 400 retard
  Carbamazepine	Initial report	08.07.2025	Other	Carbamazepine AL 200 retard
  Quetiapine fumarate (Ph.Eur.)	Change notification	08.07.2025	Other	Quetiapine-ratiopharm 300 mg prolonged-release tablets
  Oxazepam	Change notification	08.07.2025	Other	Oxa-CT 10 mg tablets
  Quetiapine fumarate (Ph.Eur.)	Change notification	08.07.2025	Other	Quetiapine AbZ 150 mg prolonged-release tablets
  Calcium acetate hydrate ((with information on water content (1:x)))	Initial report	07.07.2025	Production problem	Renacet 950 mg
  Midodrine hydrochloride	Initial report	07.07.2025	Other	Gutron tablets
  DL-lysine acetylsalicylate – glycine (9:1)	Initial report	07.07.2025	Production problem	Acetylsalicylic acid Panpharma i.v. 500 mg
  Salbutamol sulfate	Initial report	07.07.2025	Other	Bronchospray Autohaler

• 2025.07.07
  BfArMボトルネック・レポート（2025年6月30日～7月6日）

  Active ingredients	Notification type	Date of last notification	Type of reason	AM designation
  Fampridine	Change notification	04.07.2025	Other	Fampyra 10 mg prolonged-release tablets – OP28(2×14)(Bl)
  Dexamethasone; neomycin sulfate; polymyxin B sulfate	Change notification	04.07.2025	Production problem	Isopto-Max
  Olanzapine embonate monohydrate	First notification	04.07.2025	Production problem	ZYPADHERA 210 mg powder and solvent for the preparation of a suspension for depot injection – OP(483mg+3ml)
  Acetylcholine chloride	Change notification	04.07.2025	Production problem	Miochol-E Powder and solvent for the preparation of an instillation solution for intraocular use
  Terazosin hydrochloride dihydrate	Change notification	04.07.2025	Other	Heitrin 1mg
  Terazosin hydrochloride dihydrate	Change notification	04.07.2025	Other	Heitrin 5mg
  Terazosin hydrochloride dihydrate	Change notification	04.07.2025	Other	Heitrin 2mg
  Nitrendipine	Change notification	04.07.2025	Production problem	Nitrendipine Aristo 10 mg film-coated tablets
  Rivastigmine hydrogentartrate	Change notification	04.07.2025	Production problem	Rivastigmine Aurobindo 6 mg hard capsules
  Celecoxib	Change notification	04.07.2025	Production problem	Celecoxib Aurobindo 200 mg hard capsules
  Duloxetine hydrochloride	Change notification	04.07.2025	Production problem	Duloxetine PUREN 40 mg enteric-coated hard capsules
  Duloxetine hydrochloride	Change notification	04.07.2025	Production problem	Duloxetine Aurobindo 60 mg enteric-coated hard capsules
  Methylphenidate hydrochloride	Change notification	03.07.2025	Production problem	Methysym
  Methylphenidate hydrochloride	Change notification	03.07.2025	Production problem	Methysym
  Methylphenidate hydrochloride	Change notification	03.07.2025	Production problem	Methysym
  Methylphenidate hydrochloride	Change notification	03.07.2025	Production problem	Methysym
  Methylphenidate hydrochloride	Change notification	03.07.2025	Production problem	Methysym
  Methylphenidate hydrochloride	Change notification	03.07.2025	Production problem	Methysym
  Terazosin hydrochloride dihydrate	Change notification	03.07.2025	Other	Tera TAD 2mg
  Terazosin hydrochloride dihydrate	Change notification	03.07.2025	Other	Tera TAD 5mg
  Terazosin hydrochloride dihydrate	Change notification	03.07.2025	Other	Tera TAD 10mg
  Cefotaxime sodium	First notification	03.07.2025	Production problem	Cefotaxime-saar 2 g Powder for solution for injection or infusion
  Fluoxetine hydrochloride	First notification	03.07.2025	Other	Fluoxetine beta 40
  Fluoxetine hydrochloride	First notification	03.07.2025	Other	Fluoxetine beta 20
  Zoledronic acid monohydrate	First notification	03.07.2025	Other	Zole – 1 A Pharma 5 mg/100 ml solution for infusion
  Zoledronic acid monohydrate	First notification	03.07.2025	Other	Aclasta 5 mg solution for infusion – OP(1x100ml)
  Insulin human ((with manufacturing details))	First notification	03.07.2025	Other	Huminsulin Profile III KwikPen 100 IU/ml injection suspension
  Quetiapine fumarate (Ph.Eur.)	First notification	03.07.2025	Production problem	Quetiapine Glenmark 150 mg prolonged-release tablets
  Mometasone furoate (Ph.Eur.)	Change notification	03.07.2025	Production problem	Mometasone Glenmark 1mg/g ointment
  Urapidil	Change notification	03.07.2025	Other	Urapidil Stragen 30 mg delayed-release hard capsules
  Urapidil	Change notification	03.07.2025	Other	Urapidil Stragen 60 mg delayed-release hard capsules
  Thioctic acid trometamol salt (1:1)	Change notification	03.07.2025	Other	Thioctacid 600 T
  Solifenacin succinate	Change notification	03.07.2025	Production problem	Solifenacin succinate Aurobindo 5 mg film-coated tablets
  Prednisolone acetate	Change notification	03.07.2025	Production problem	Predni-POS 1 %
  Fluorometholone	Change notification	03.07.2025	Production problem	fluoropos
  Hydrocortisone acetate (Ph.Eur.)	Change notification	03.07.2025	Production problem	Hydrocortisone POS N 2.5%
  Dexamethasone dihydrogen phosphate disodium (Ph.Eur.); gentamicin sulphate	Change notification	03.07.2025	Production problem	Dexa-Gentamicin
  Acyclovir	Change notification	03.07.2025	Production problem	Virupos
  Clarithromycin	Change notification	03.07.2025	Production problem	CLARITHROMYCIN BASICS 250 mg/5 ml granules for the preparation of an oral suspension
  Esomeprazole hemimagnesium	Change notification	03.07.2025	Production problem	ESOMEPRAZOL BASICS 40 mg gastro-resistant hard capsules
  Esomeprazole hemimagnesium	Change notification	03.07.2025	Production problem	ESOMEPRAZOL BASICS 20 mg enteric-coated hard capsules
  Insulin lispro	First notification	03.07.2025	Other	Liprolog 100 E/ml solution for injection in cartridge – OP(5x3ml)
  Anti-human T-lymphocyte immunoglobulin from horse	First notification	03.07.2025	Other	Atgam
  Fluorouracil	Change notification	03.07.2025	Other	Benda-5 FU
  Vancomycin hydrochloride	Change notification	03.07.2025	Production problem	Vancomycin Lyomark 1000 mg powder for concentrate for solution for infusion or oral solution
  Vancomycin hydrochloride	Change notification	03.07.2025	Production problem	Vancomycin Lyomark 500 mg
  Fluorouracil	Change notification	03.07.2025	Other	Fluorouracil Hikma 50 mg/ml solution for injection
  Sodium (methylprednisolone-21-succinate)	Change notification	02.07.2025	Other	Urbason solubile forte 1000 mg
  Insulin glargine	Change notification	02.07.2025	Other	Semglee
  Salbutamol sulphate	Change notification	02.07.2025	Other	Sultanol metered dose aerosol
  Insulin glargine	First notification	02.07.2025	Other	Semglee 100 units/ml solution for injection in prefilled pen – OP(5x3ml)
  Ampicillin sodium	Change notification	02.07.2025	Production problem	Ampicillin Eberth 2 g powder for solution for injection/infusion
  Ampicillin sodium	Change notification	02.07.2025	Production problem	Ampicillin Eberth 500 mg powder for solution for injection/infusion
  Fosfomycin sodium (Ph.Eur.)	Change notification	02.07.2025	Production problem	Fosfomycin Eberth 2 g powder for solution for infusion
  Fosfomycin sodium (Ph.Eur.)	Change notification	02.07.2025	Production problem	Fosfomycin Eberth 4 g powder for solution for infusion
  Epoetin beta	First notification	02.07.2025	Other	NeoRecormon 3000 IU solution for injection in prefilled syringe – OP6
  Ibandronate sodium monohydrate	Change notification	02.07.2025	Other	Bondronat 50 mg film-coated tablets – OP28
  Methylphenidate hydrochloride	First notification	02.07.2025	Other	Methylphenidate AL 27 mg prolonged-release tablets
  Ipratropium bromide (Ph.Eur.)	Change notification	02.07.2025	Production problem	Ipratropium Teva 250 micrograms / 1 ml solution for nebulizer
  Buprenorphine	Change notification	02.07.2025	Other	Buprenorphine AWD Matrix 70 microgram/h transdermal patch
  Fluoxetine hydrochloride	First notification	02.07.2025	Production problem	Fluoxetine Stada 20 mg tablets for oral suspension
  Ribavirin	First notification	02.07.2025	Other	Ribavirin-ratiopharm 400 mg film-coated tablets
  Ribavirin	Change notification	02.07.2025	Other	Ribavirin-ratiopharm 200 mg film-coated tablets
  Buprenorphine	Change notification	02.07.2025	Other	Buprenorphine-ratiopharm 70 microgram/h transdermal patch
  Buprenorphine	Change notification	02.07.2025	Other	Buprenorphine-ratiopharm 52.5 micrograms/h transdermal patch
  Buprenorphine	Change notification	02.07.2025	Other	Buprenorphine-ratiopharm 35 micrograms/h transdermal patch
  Aprepitant	First notification	02.07.2025	Production problem	Aprepitant STADA 125 mg and 80 mg hard capsules
  Rizatriptan benzoate	Change notification	01.07.2025	Production problem	Rizatriptan Glenmark 5 mg tablets
  Rizatriptan benzoate	Change notification	01.07.2025	Production problem	Rizatriptan Glenmark 5 mg orodispersible tablets
  Rizatriptan benzoate	Change notification	01.07.2025	Production problem	Rizatriptan Glenmark 10 mg orodispersible tablets
  Rizatriptan benzoate	Change notification	01.07.2025	Production problem	Rizatriptan Glenmark 10 mg tablets
  Quetiapine fumarate (Ph.Eur.)	Change notification	01.07.2025	Production problem	Quetiapine Glenmark 200 mg prolonged-release tablets
  Linezolid	Change notification	01.07.2025	Production problem	Linezolid Glenmark 600 mg film-coated tablets
  Galantamine hydrobromide	Change notification	01.07.2025	Production problem	Galantamine Glenmark 16 mg hard capsules, delayed release
  Galantamine hydrobromide	Change notification	01.07.2025	Production problem	Galantamine Glenmark 8 mg hard capsules, delayed release
  Galantamine hydrobromide	Change notification	01.07.2025	Production problem	Galantamine Glenmark 24 mg hard capsules, delayed-release
  Trazodone hydrochloride	Change notification	01.07.2025	Production problem	Trazodone Glenmark 100 mg tablets
  Phenoxymethylpenicillin potassium	Change notification	01.07.2025	Other	Pen Mega – 1 A Pharma
  Aprepitant	Change notification	01.07.2025	Other	Aprepilor 80 mg hard capsules
  Aprepitant	Change notification	01.07.2025	Other	Aprepilor 125 mg/80 mg hard capsules
  Haloperidol decanoate	Change notification	01.07.2025	Production problem	Haloperidol-neuraxpharm decanoate 50 mg/ml
  Haloperidol decanoate	Change notification	01.07.2025	Production problem	Haloperidol neuraxpharm decanoate 100 mg/ml
  Quetiapine fumarate (Ph.Eur.)	Change notification	01.07.2025	Other	Quetiapine-neuraxpharm 50 mg prolonged-release tablets
  Quetiapine fumarate (Ph.Eur.)	Change notification	01.07.2025	Other	Quetiapine-neuraxpharm 150 mg prolonged-release tablets
  Quetiapine fumarate (Ph.Eur.)	Change notification	01.07.2025	Other	Quetiapine-neuraxpharm 200 mg prolonged-release tablets
  Quetiapine fumarate (Ph.Eur.)	Change notification	01.07.2025	Other	Quetiapine-neuraxpharm 300 mg prolonged-release tablets
  Quetiapine fumarate (Ph.Eur.)	Change notification	01.07.2025	Other	Quetiapine-neuraxpharm 400 mg prolonged-release tablets
  Quetiapine fumarate (Ph.Eur.)	Change notification	01.07.2025	Other	Quetiapine-neuraxpharm 600 mg prolonged-release tablets
  Galantamine hydrobromide	Change notification	01.07.2025	Other	Galantamine-neuraxpharm 8 mg delayed-release hard capsules
  Galantamine hydrobromide	Change notification	01.07.2025	Other	Galantamine-neuraxpharm 16 mg hard capsules, prolonged-release
  Galantamine hydrobromide	Change notification	01.07.2025	Other	Galantamine-neuraxpharm 24 mg hard capsules, delayed-release
  Atomoxetine hydrochloride	Change notification	01.07.2025	Production problem	Atomoxetine-neuraxpharm 10 mg hard capsules
  Paliperidone palmitate	Change notification	01.07.2025	Other	Paliperidone AL 150 mg depot injection suspension in a prefilled syringe
  Atomoxetine hydrochloride	Change notification	01.07.2025	Production problem	Atomoxetine-neuraxpharm 18 mg hard capsules
  Paliperidone palmitate	Change notification	01.07.2025	Other	Paliperidone AL 75 mg depot injection suspension in a prefilled syringe
  Atomoxetine hydrochloride	Change notification	01.07.2025	Production problem	Atomoxetine-neuraxpharm 25 mg hard capsules
  Paliperidone palmitate	Change notification	01.07.2025	Other	Paliperidone AL 50 mg depot injection suspension in a prefilled syringe
  Atomoxetine hydrochloride	Change notification	01.07.2025	Production problem	Atomoxetine-neuraxpharm 40 mg hard capsules
  Paliperidone palmitate	Change notification	01.07.2025	Other	Paliperidone AL 25 mg depot injection suspension in a prefilled syringe
  Atomoxetine hydrochloride	Change notification	01.07.2025	Production problem	Atomoxetine-neuraxpharm 80 mg hard capsules
  Atomoxetine hydrochloride	Change notification	01.07.2025	Production problem	Atomoxetine-neuraxpharm 100 mg hard capsules
  Pramipexole dihydrochloride monohydrate	Change notification	01.07.2025	Other	Pramipexole HEXAL 0.26 mg prolonged-release tablets
  Methylphenidate hydrochloride	Change notification	01.07.2025	Production problem	Equasym Retard 40 mg modified-release hard capsules
  Tranexamic acid	Change notification	01.07.2025	Other	Cyklokapron
  Mupirocin calcium (Ph.Eur.)	Change notification	30.06.2025	Production problem	Turixin
  Atorvastatin calcium trihydrate (Ph.Eur.)	Change notification	30.06.2025	Other	Atorvastatin Micro Labs 10 mg film-coated tablets
  Atorvastatin calcium trihydrate (Ph.Eur.)	Change notification	30.06.2025	Other	Atorvastatin Micro Labs 20 mg film-coated tablets
  Atorvastatin calcium trihydrate (Ph.Eur.)	Change notification	30.06.2025	Other	Atorvastatin Micro Labs 30 mg film-coated tablets
  Atorvastatin calcium trihydrate (Ph.Eur.)	Change notification	30.06.2025	Other	Atorvastatin Micro Labs 40 mg film-coated tablets
  Atorvastatin calcium trihydrate (Ph.Eur.)	Change notification	30.06.2025	Other	Atorvastatin Micro Labs 60 mg film-coated tablets
  Atorvastatin calcium trihydrate (Ph.Eur.)	Change notification	30.06.2025	Other	Atorvastatin Micro Labs 80 mg film-coated tablets
  Ipratropium bromide (Ph.Eur.); salbutamol sulphate	First notification	30.06.2025	Production problem	COMBIPRASAL 0.5 mg / 2.5 mg solution for nebulizer
  Ipratropium bromide	First notification	30.06.2025	Production problem	Ipratropium bromide 125 micrograms / 1 ml ampoule
  Ipratropium bromide	First notification	30.06.2025	Production problem	Ipratropium bromide 250 micrograms / 1 ml Stulln
  Quetiapine fumarate (Ph.Eur.)	Change notification	30.06.2025	Other	Seroquel Prolong 400 mg prolonged-release tablets
  Sertraline hydrochloride	Change notification	30.06.2025	Other	Sertraline TAD 100 mg film-coated tablets
  Sertraline hydrochloride	Change notification	30.06.2025	Other	Sertraline TAD 50 mg film-coated tablets
  Trimipramine mesilate	Change notification	30.06.2025	Other	Trimipramine – 1 A Pharma 40 mg/ml Oral drops, solution
  Doxorubicin hydrochloride	Change notification	30.06.2025	Other	Doxorubicin HEXAL 2 mg/ml
  Hydromorphone hydrochloride	Change notification	30.06.2025	Other	Hydromorphone HEXAL 2.6 mg hard capsules
  Terbutaline sulphate (Ph.Eur.)	Change notification	30.06.2025	Production problem	BRICANYL 0.5 mg
  Chlortalidone	Change notification	30.06.2025	Other	Chlortalidone HEXAL 25 mg tablets
  Chlortalidone	Change notification	30.06.2025	Other	Chlortalidone HEXAL 50 mg tablets

• 2025.07.28
  ANSMフランス供給不足情報（2025年7月21日～7月27日）

  Active ingredients	Status	Update	Specialty
  lenalidomide	Supply tension	25/07/2025	Lenalidomide Mylan, capsule
  potassium canrenate/trometamol	Marketing discontinued	25/07/2025	Soludactone 100 mg and 200 mg, lyophilisate and solution for parenteral use
  sodium lactate	Available for use	25/07/2025	Sodium lactate APHP 11.2% (w/v) solution for infusion
  nystatin	Available for use	25/07/2025	Mycostatin 100,000 IU/ml, oral suspension
  cyamemazine	Supply voltage	25/07/2025	Tercian 50 mg/5 ml, solution for injection in ampoule
  tobramycin	Out of stock	24/07/2025	Tobi Podhaler 28 mg, powder for inhalation capsule
  Synthetic vitamin A concentrate, oily form	Supply tension	24/07/2025	Vitamin A Dulcis 25 000 I.U. per 100 g, ophthalmic ointment
  furosemide	Available for use	24/07/2025	Furosemide Teva 500 mg, scored tablet
  temozolomide	Supply tension	24/07/2025	Temodal 2.5 mg/ml, powder for solution for infusion
  acyclovir	Available for use	23/07/2025	Zovirax 500 mg, powder for injectable solution (IV)
  hydrocortisone	Available for use	21/07/2025	Hydrocortisone Roussel 10 mg, comprimé sécable
  ascorbic acid	Supply tension	21/07/2025	Laroscorbine 1 g/5 ml, I.V. injectable solution in ampoule
  fluorouracil	Supply tension	21/07/2025	Fluorouracil Pfizer 50 mg/ml, dilutable solution for infusion  20 ml and 100 ml bottle

• 2025.07.21
  ANSMフランス供給不足情報（2025年7月14日～7月20日）

  Active ingredients	Status	Update	Specialty
  micafungin sodium	Out of stock	18/07/2025	Micafungin Viatris 100 mg, powder for solution for infusion
  micafungin sodium	Supply tension	18/07/2025	Micafungin Viatris 50 mg, powder for solution for infusion
  fluorouracil	Marketing discontinuation	18/07/2025	Fluorouracil Teva 5000 mg/100 mL, dilutable solution for infusion, 100 ml bottle
  aztreonam	Supply tension	18/07/2025	Azactam 1 g, powder and solution for parenteral use
  olanzapine (pamoate) monohydrate	Supply tension	18/07/2025	Zypadhera, powder and solvent for prolongedrelease suspension for injection
  diltiazem (hydrochloride)	Available for use	18/07/2025	Bi Tildiem L.P. 120 mg, sustainedrelease coated tablet
  insulin aspart ((yeast/saccharomyces cerevisiae))	Supply tension	17/07/2025	Fiasp Flextouch 100 units/ml, solution for injection in prefilled pen
  temozolomide	Supply tension	17/07/2025	Temodal 2.5 mg/ml, powder for solution for infusion
  Calcium folinate and levofolinate	Supply tension	17/07/2025	Calcium folinate 10 mg/ml, solution for injection/infusion
  calcium (carbonate)	Available for use	17/07/2025	Calcidia 1.54 g, granulated oral suspension in dose sachet
  ipratropium (bromide)	Out of stock	17/07/2025	Ipratropium Teva 0.5 mg/2 ml adults, solution for inhalation by nebulizer in singledose container
  isavuconazonium (sulfate d’)	Available again	17/07/2025	Cresemba 200 mg, powder for solution for diluted infusion
  basiliximab (mammal/mouse/Sp2/O)	Supply tension	17/07/2025	Simulect 20 mg, powder and solvent for solution for injection or infusion
  mivacurium chloride	Available for use	17/07/2025	Mivacron 10 mg/5 ml and 20 mg/10 ml, solution for injection (IV)
  risperidone	Supply tension	17/07/2025	Risperidone 0.5 mg, 1 mg, 2 mg 3 mg and 4 mg orodispersible tablet
  fluorouracil	Supply tension	17/07/2025	Fluorouracil Pfizer 50 mg/ml, dilutable solution for infusion  20 ml and 100 ml bottle
  valproic acid, sodium (valproate)	Supply tension	17/07/2025	Micropakine L.P., sustainedrelease granules in a sachet
  etoposide	Supply tension	16/07/2025	Etoposide Teva, solution for injection
  calcium heparin	Supply tension	15/07/2025	Calciparin subcutaneous 12 500 IU/0.5 ml, solution for injection
  Vertéporfine	Supply tension	15/07/2025	Visudyne 15 mg, powder for solution for infusion
  adrenaline	Available for use	15/07/2025	Anapen 150 micrograms/0.3 ml and 300 micrograms/0.3 ml, solution for injection in prefilled syringe
  bezafibrate	Available for use	15/07/2025	Befizal 200 mg, filmcoated tablet
  ritonavir	Out of stock	15/07/2025	Ritonavir Arrow 100 mg, filmcoated tablet

• 2025.07.14
  ANSMフランス供給不足情報（2025年7月7日～7月13日）

  Active ingredients	Status	Update	Specialty
  clomipramine (hydrochloride)	Supply tension	11/07/2025	Anafranil 25 mg, coated tablet
  clomipramine (hydrochloride)	Supply tension	11/07/2025	Clomipramine Viatris 25 mg, filmcoated tablet
  tolvaptan	Supply tension	10/07/2025	Tolvaptan Biogaran 15 mg and 45 mg, tablet
  alfacalcidol	Supply tension	10/07/2025	UnAlfa 1 microgram, oral capsule
  disopyramide (phosphate)	Available for use	10/07/2025	Rythmodan 100 mg, capsule
  cilastatin sodium, imipenem monohydrate, rebactam monohydrate	Available for use	10/07/2025	Recarbrio 500 mg/500 mg/250 mg, powder for solution for infusion
  valproic acid, sodium (valproate de)	Supply tension	09/07/2025	Micropakine L.P., sustainedrelease granules in a dose sachet
  bendamustine (hydrochloride) monohydrate	Supply tension	09/07/2025	Bendamustine Hikma 2.5 mg/ml, powder for solution for infusion
  methylprednisolone (hydrogen-succinate)	Out of stock	09/07/2025	Methylprednisolone Viatris 40 mg, powder for solution for injection (IMIV)
  Varicella-Zoster Virus (VZV) glycoprotein E antigen (recombinant, adjuvanted) ((MAMMIFERE/HAMSTER/CELLULES CHO))	Supply tension	08/07/2025	Shingrix, powder and suspension for injectable suspension. Herpes zoster vaccine (recombinant, adjuvanted)
  cyamemazine	Supply tension	08/07/2025	Tercian 50 mg/5 ml, solution for injection in ampoule
  raltegravir potassium	Available for use	08/07/2025	Isentress 100 mg, granules for oral suspension
  insulin aspart isophane biphasic (yeast/saccharomyces cerevisiae)	Available for use	08/07/2025	NovoMix 50 Flexpen 100 Units/ml, suspension for injection in prefilled pen
  etilefrine	Available for use	08/07/2025	Effortil 5 mg, tablet
  risperidone	Supply tension	07/07/2025	Risperidone 0.5 mg, 1 mg, 2 mg 3 mg and 4 mg orodispersible tablet
  insulin aspart (yeast/saccharomyces cerevisiae)	Supply tension	07/07/2025	Fiasp Pumpcart 100 units/ml, solution for injection in cartridge
  cyclophosphamide	Available for use	07/07/2025	Endoxan 50 mg, coated tablet

• 2025.07.07
  ANSMフランス供給不足情報（2025年6月30日～7月6日）

  Active ingredients	Status	Update	Specialty
  retinol palmitate	Supply tension	04/07/2025	Vitamin A Provepharm 100 000 I.U./2 ml, solution for injection (I.M.)
  sugammadex sodique	Supply tension	04/07/2025	Sugammadex 100 mg/mL, solution for injection 5 ml vials
  fusidic acid	Out of stock	04/07/2025	Fucithalmic 1%, ophthalmic gel
  ondansetron	Out of stock	04/07/2025	Zophren 4 mg/5 ml, syrup
  lithium (carbonate)	Available again	04/07/2025	Teralithe 250 mg, scored tablet
  carbamazepine	Out of stock	03/07/2025	Carbamazepine Viatris L.P. 400 mg, extended release scored tablet
  carbamazepine	Out of stock	03/07/2025	Carbamazepine Viatris L.P. 200 mg, extended release scored tablet
  insulin aspart ((yeast/saccharomyces cerevisiae))	Supply tension	03/07/2025	Novorapid Pumpcart 100 units/ml, solution for injection in cartridge
  peginterferon alfa-2a	Supply tension	03/07/2025	Pegasys 90 micrograms, 135 micrograms and 180 micrograms solution for injection in pre filled syringe
  disopyramide (phosphate)	Available again	03/07/2025	Rythmodan 250 mg sustained release, coated tablet
  mitomycin	Supply tension	03/07/2025	Mitomycin Accord 20 mg, powder for solution for injection / infusion or intravesical route
  human coagulation factor Willebrand	Supply tension	03/07/2025	Wilfactin 100 IU/mL, powder and solvent for solution for injection
  dexamethasone (sodium phosphate)	Supply tension	02/07/2025	Dexocol 1 mg/mL, eye drops solution
  tranexamic acid	Supply tension	02/07/2025	Exacyl 500 mg, film coated tablet
  potassium (bicarbonate)/potassium (citrate)	Available again	02/07/2025	Sibnayal 8 mEq, sustained release granules
  carbamazepine	Supply tension	01/07/2025	Tegretol L.P. 400 mg, extended release scored film coated tablet
  methylphénidate (chlorhydrate de)	Supply tension	01/07/2025	Méthylphénidate Biogaran, comprimé à libération prolongée
  colchicine, opium (powder), tiemonium (metilsulfate)	Supply tension	01/07/2025	Colchimax, scored film coated tablet and Colchicine Opocalcium 1 mg, scored tablet
  naloxegol (oxalate)	Out of stock	01/07/2025	Moventig 25 mg, film coated tablet
  fluorouracil	Out of stock	01/07/2025	Fluorouracil Pfizer 50 mg/ml, dilutable solution for infusion   100 ml bottle
  disopyramide (phosphate)	Out of stock	30/06/2025	Rythmodan 100 mg, capsule
  praziquantel	Available again	30/06/2025	Biltricide 600 mg, film coated quadrisectible tablet
  acetazolamide	Available again	30/06/2025	Diamox 250 mg, scored tablet
  	Supply tension	30/06/2025	Repevax, suspension for injection in pre filled syringe. Diphtheria, tetanus, pertussis (acellular, multicomponent) and poliomyelitis vaccine (inactivated), (adsorbed, reduced antigen content)

• 2025.07.01
  NICE医薬品情報サービス（2025年6月23日～6月27日）

  Serious shortage protocol (SSP083) for venlafaxine 37.5mg modified-release tablets issued

  In response to significant ongoing disruption to the supply of venlafaxine 37.5mg modified-release tablets, an SSP has been issued that allows for venlafaxine 37.5mg modified-release capsules to be provided in place of the modified release tablets. SSP expiry date 01 August 2025.

  venlafaxine37.5mgの放出性錠剤の供給に対する重大な継続的な混乱に対応して、放出性錠剤の代わりにvenlafaxine37.5mgの放出性カプセルを提供できるようにする深刻な供給不足プロトコルSerious Shortage Protocol (SSP)が発行されました。SSPの有効期限は2025年8月1日です。
  （venlafaxine：セロトニン・ノルアドレナリン再取り込み阻害薬：SNRI、商品名イフェクサー：ヴィアトリス製薬）

• 2025.07.29
  NICE医薬品情報サービス（2025年7月21日～7月25日）

  英国でのインスリン供給停止

  Medicine supply notification: Vials of Humulin® I, Humulin® S, Humulin® M3, and Humalog® Mix25 are being discontinued

  Supply anticipated to be exhausted by end of April/May 2026. Humulin I, Humulin S, Humulin M3, and Humalog Mix25 in cartridges (for use with HumaPen Savvio reusable pen) remain available. Humulin I, Humulin M3 and Humalog Mix25 in disposable KwikPens remain available.

  供給は2026年4月末から5月末までに枯渇する見込みです。カートリッジ入りのHumulin I、Humulin S、Humulin M3、およびHumalog Mix25(HumaPen Savvio再利用可能なペンで使用)は引き続き入手可能です。使い捨てのKwikPensに入ったHumulin I、Humulin M3、Humalog Mix25は引き続き入手可能です。

  Source: Community Pharmacy England

   

  Medicine supply notification: Vial presentations of Hypurin® Porcine Isophane, Hypurin® Porcine Neutral and Hypurin® Porcine 30/70 Mix are being discontinued

  Supply anticipated to be exhausted by end of Sept 2025, mid-Feb 2026, & end of July 2026, respectively. Cartridge presentations of these products remain available, which are compatible with AutoPen® Classic, and with new mypen®2, which will be available from late Sept 2025.

  供給はそれぞれ2025年9月末、2026年2月中旬、2026年7月末までに枯渇すると予想されています。これらの製品のカートリッジ プレゼンテーションは引き続き利用可能で、AutoPen® Classic と互換性があり、2025 年 9 月下旬から発売される新しい mypen®2 と互換性があります。

  Source: Community Pharmacy England