Medicine supply notification: Nifedipine (Fortipine® LA) 40mg modified-release tablets
2025年12月8日、保健・社会福祉省（Department of Health and Social Care：DHSC）は、Nifedipine (Fortipine® LA) 40mg徐放性錠の医薬品供給通知（medicine supply notification）を発出した。
| Active ingredients |
| Date of last message | Type of reason | AM designation | |
| Iron(III) sodium D-gluconate hydroxide oxide complex (approx. 2:1:1:x:y) | Change notification | 12.12.2025 | Other | Ferrlecit 40 mg | |
| Clomipramine hydrochloride | Initial report | 12.12.2025 | Other | Clomipramine-neuraxpharm 75 mg retard | |
| Epoetin zeta | Initial report | 12.12.2025 | Other | Retacrit 40,000 IU/1 ml solution for injection in pre-filled syringe | |
| Epoetin zeta | Initial report | 12.12.2025 | Other | Retacrit 40,000 IU/1 ml solution for injection in pre-filled syringe | |
| Atorvastatin calcium trihydrate (Ph.Eur.) | Initial report | 11.12.2025 | Other | Atorvastatin Micro Labs 10 mg film-coated tablets | |
| Atorvastatin calcium trihydrate (Ph.Eur.) | Change notification | 11.12.2025 | Other | Atorvastatin Micro Labs 30 mg film-coated tablets | |
| Atorvastatin calcium trihydrate (Ph.Eur.) | Change notification | 11.12.2025 | Other | Atorvastatin Micro Labs 60 mg film-coated tablets | |
| Fluoxetine hydrochloride | Change notification | 11.12.2025 | Other | Fluoxetine Micro Labs 60 mg hard capsules | |
| Fluoxetine hydrochloride | Change notification | 11.12.2025 | Other | Fluoxetine Micro Labs 30 mg hard capsules | |
| Quetiapine fumarate (Ph.Eur.) | Change notification | 11.12.2025 | Other | Quetiapine AL 200 mg prolonged-release tablets | |
| Prednicarbate | Change notification | 11.12.2025 | Other | Prednicarbate acis solution | |
| Zoledronic acid monohydrate | Initial report | 11.12.2025 | Other | Zoledronic acid AL 4 mg/100 ml infusion solution | |
| Ibandronate sodium monohydrate | Initial report | 11.12.2025 | Other | Ibandronic acid AL 3 mg solution for injection in a pre-filled syringe | |
| Fibrinogen, human | Initial report | 10.12.2025 | Other | Fibryga | |
| Sodium (hydrocortisone-21-succinate) | Change notification | 10.12.2025 | Production problem | Hydrocortisone PANPHARMA 100 mg | |
| Methylphenidate hydrochloride | Change notification | 10.12.2025 | Other | CONCERTA 54 mg prolonged-release tablets | |
| Methylphenidate hydrochloride | Change notification | 10.12.2025 | Other | CONCERTA 36 mg prolonged-release tablets | |
| Methylphenidate hydrochloride | Change notification | 10.12.2025 | Other | CONCERTA 27 mg prolonged-release tablets | |
| Methylphenidate hydrochloride | Change notification | 10.12.2025 | Other | CONCERTA 18 mg prolonged-release tablets | |
| Dimenhydrinate | Initial report | 10.12.2025 | Production problem | Dimenhydrinate PANPHARMA 6.2 mg/ml solution for injection (i.v.) | |
| Metformin hydrochloride | Initial report | 10.12.2025 | Other | Metformin 500 – 1 A Pharma | |
| Candesartan cilexetil | Initial report | 10.12.2025 | Other | Blopress 16 mg | |
| Colistimethate sodium | Initial report | 10.12.2025 | Production problem | Colistin CF | |
| Risperidone | Change notification | 10.12.2025 | Production problem | Risperidone-ratiopharm 50 mg powder and solvent for the preparation of a depot injection suspension | |
| Risperidone | Change notification | 10.12.2025 | Production problem | Risperidone-ratiopharm 37.5 mg powder and solvent for the preparation of a depot injection suspension | |
| Risperidone | Change notification | 10.12.2025 | Production problem | Risperidone-ratiopharm 25 mg powder and solvent for the preparation of a depot injection suspension | |
| Ribavirin | Change notification | 10.12.2025 | Production problem | Ribavirin-ratiopharm 200 mg film-coated tablets | |
| Ribavirin | Change notification | 10.12.2025 | Other | Ribavirin-ratiopharm 400 mg film-coated tablets | |
| Levothyroxine sodium | Initial report | 10.12.2025 | Other | L-thyroxine-Na-ratiopharm 50 microgram tablets | |
| Levothyroxine sodium | Initial report | 10.12.2025 | Other | L-Thyroxine-Na-ratiopharm 25 microgram tablets | |
| Isoniazid; pyridoxine hydrochloride | Initial report | 09.12.2025 | Other | Isozid comp. 200 mg N | |
| Isoniazid | Initial report | 09.12.2025 | Other | Isozid 0.5 N | |
| Pyrazinamide | Initial report | 09.12.2025 | Production problem | Pyrafat 500mg | |
| Dapsone | Initial report | 09.12.2025 | Production problem | Dapson-Fatol | |
| Filgrastim | Initial report | 09.12.2025 | Other | Nivestim 12 million E/0.2 ml injection/infusion solution – OP (5×0.2 ml) | |
| Adalimumab | Initial report | 09.12.2025 | Other | Amsparity | |
| Adalimumab | Initial report | 09.12.2025 | Other | Amsparity | |
| Adalimumab | Initial report | 09.12.2025 | Other | Amsparity | |
| Adalimumab | Initial report | 09.12.2025 | Other | Amsparity | |
| Risedronate sodium 2.5 hydrate (Ph.Eur.) | Initial report | 09.12.2025 | Other | Risedronate Aurobindo once weekly 35 mg film-coated tablets | |
| Terazosin hydrochloride dihydrate | Change notification | 09.12.2025 | Other | Heitrin 1mg | |
| Terazosin hydrochloride dihydrate | Change notification | 09.12.2025 | Other | Heitrin 5mg | |
| Terazosin hydrochloride dihydrate | Change notification | 09.12.2025 | Other | Heitrin 2 mg | |
| Metamizole sodium monohydrate | Initial report | 08.12.2025 | Production problem | Novaminsulfon – 1 A Pharma Drops | |
| Methylphenidate hydrochloride | Initial report | 08.12.2025 | Other | Equasym Retard 40 mg hard capsules with modified release | |
| Atorvastatin calcium trihydrate (Ph.Eur.) | Initial report | 08.12.2025 | Other | Atorvastatin – 1A Pharma 40 mg film-coated tablets | |
| Atorvastatin calcium trihydrate (Ph.Eur.) | Initial report | 08.12.2025 | Other | Atorvastatin – 1A Pharma 10 mg film-coated tablets | |
| Quetiapine fumarate (Ph.Eur.) | Change notification | 08.12.2025 | Other | Seroquel Prolong 50 mg prolonged-release tablets | |
| Quetiapine fumarate (Ph.Eur.) | Change notification | 08.12.2025 | Other | Seroquel Prolong 300 mg prolonged-release tablets | |
| Quetiapine fumarate (Ph.Eur.) | Change notification | 08.12.2025 | Other | Seroquel Prolong 200 mg prolonged-release tablets |
| Active ingredients | Status | Update | Specialty |
| propranolol hydrochloride | Supply tension | 12/12/2025 | Propranolol 40 mg tablets |
| prednisolone (sodium metasulfobenzoate) | Return to availability | 12/12/2025 | Prednisolone 5 mg and 20 mg, orodispersible tablet and effervescent tablet |
| prednisone | Return to availability | 12/12/2025 | Prednisone 5 mg and 20 mg, breakable tablet |
| danazol | Return to availability | 12/12/2025 | Danatrol 200 mg, capsule |
| prednisolone (acetate) | Return to availability | 11/12/2025 | Hydrocortancyl 2.5 percent, injectable suspension |
| bromfenac sodium sesquihydrate | Return to availability | 11/12/2025 | Yellox 0.9 mg/mL, eye drops, solution |
| pristinamycin | Return to availability | 10/12/2025 | Pyostacin 500 mg, film-coated tablet |
| fluorouracil | Supply tension | 09/12/2025 | Fluorouracil Accord 50 mg/mL, solution for dilution for infusion, 5 mL, 20 mL, and 100 mL vials |
| ifosfamide | Supply tension | 08/12/2025 | Holoxan 2000 mg, powder for parenteral use |
| Normal human immunoglobulin (IgG) | Supply tension | 08/12/2025 | Normal human immunoglobulin IV and SC (based on) |
| lithium (carbonate) | Supply tension | 08/12/2025 | Teralithe 250 mg, breakable tablet |
| clomipramine (hydrochloride) | Return to availability | 08/12/2025 | Anafranil 25 mg, coated tablet |
| varenicline (tartrate) | Supply tension | 08/12/2025 | Champix 0.5 mg and 1 mg, film-coated tablet |
| Ingredients | Product Name | Formulation | Report Category | Report Date |
| Penciclovir | Penciclovir Cream (Penciclovir) | Skin Cream | Supply Discontinuation | 2025-12-12 |
| Temozolomide | Temozolomide Capsules 20 milligrams (Temozolomide) | Hard Capsule, Powder | Supply Shortage | 2025-12-11 |
| Bambuterol Hydrochloride | Bambec Tablet 10mg (Bambuterol Hydrochloride) | Najeong | Supply Discontinuation | 2025-12-10 |
| Piperonyl butoxide, Pyrethrin extract | Gammarin Diac | Shampoo | Supply Discontinuation | 2025-12-09 |
| Hydrocortisone | Hydrocortisone Cream (Export Name: Hydrocortisone 1% Cream Max Strength, Hydrocortisone Cream) | Skin Cream | Supply Discontinuation | 2025-12-09 |
| House Dust Mite Extract | Challergan Sublingual Solution (House Dust Mite Extract) (Maintenance Therapy) | Oral Solution | Supply Discontinuation | 2025-12-08 |
| House Dust Mite Extract | Challergan Sublingual Solution (House Dust Mite Tablet Extract) (Initiation Therapy) | Oral Solution | Supply Discontinuation | 2025-12-08 |
| Active ingredients | Dosage form | Quantity of active ingredients | Shortage status | Availability | Reason | Last updated |
| gabapentin | Capsule, hard | 400 mg | Current | Limited Availability | Manufacturing | 12/12/2025 |
| prazosin hydrochloride | Tablet, uncoated | 5.476 mg | Current | Limited Availability | Unexpected increase in demand due to other sponsors unable to supply | 12/12/2025 |
| clindamycin phosphate | Injection, solution | 0 QS | Anticipated | Available | Manufacturing | 12/12/2025 |
| aripiprazole | Tablet, uncoated | 10 mg | Anticipated | Available | Manufacturing | 12/12/2025 |
| tacrolimus monohydrate | Capsule, hard | 5.112 mg | Anticipated | Available | Manufacturing | 12/12/2025 |
| pramipexole dihydrochloride monohydrate | Tablet | .25 mg | Current | Limited Availability | Manufacturing | 12/12/2025 |
| montelukast sodium | Tablet, chewable | 5.2 mg | Anticipated | Available | Manufacturing | 12/12/2025 |
| cisatracurium besilate | Injection, solution | 14.07 mg | Current | Limited Availability | Manufacturing | 12/12/2025 |
| citalopram hydrobromide | Tablet, film coated | 49.98 mg | Anticipated | Available | Manufacturing | 12/12/2025 |
| carbidopa monohydrate~levodopa~entacapone | Tablet, film coated | 54.1 mg~200 mg~200 mg | Current | Unavailable | Unexpected increase in consumer demand | 12/12/2025 |
| Pegvisomant | Injection, powder for | 10 mg | Anticipated | Available | Manufacturing | 12/12/2025 |
| amlodipine besilate~olmesartan medoxomil | Tablet, film coated | 6.935 mg~40 mg | Anticipated | Available | Manufacturing | 12/12/2025 |
| lacosamide | Tablet, film coated | 150 mg | Anticipated | Available | Manufacturing | 12/12/2025 |
| lorazepam | Tablet | 1 mg | Current | Limited Availability | Unexpected increase in demand due to other sponsors unable to supply | 12/12/2025 |
| timolol maleate~latanoprost | Eye Drops, solution | 6.83 mg/mL~.05 mg/mL | Current | Limited Availability | Manufacturing | 12/12/2025 |
| paroxetine hydrochloride | Tablet, film coated | 22.22 mg | Current | Limited Availability | Manufacturing | 12/12/2025 |
| ciprofloxacin hydrochloride | Tablet, film coated | 582.21 mg | Anticipated | Available | Manufacturing | 12/12/2025 |
| lamotrigine | Tablet, chewable | 100 mg | Current | Unavailable | Manufacturing | 12/12/2025 |
| lamotrigine | Tablet, chewable | 200 mg | Anticipated | Available | Manufacturing | 12/12/2025 |
| nitrofurantoin | Capsule, hard | 100 mg | Current | Limited Availability | Unexpected increase in consumer demand | 12/12/2025 |
| tofacitinib citrate | Solution | 1.62 mg/mL | Anticipated | Available | Manufacturing | 12/12/2025 |
| ondansetron hydrochloride dihydrate | Tablet, film coated | 4.986 mg | Anticipated | Available | Manufacturing | 12/12/2025 |
| doxepin hydrochloride | Capsule, hard | 28.25 mg | Current | Limited Availability | Manufacturing | 12/12/2025 |
| clonidine hydrochloride | Tablet, uncoated | 150 microgram | Current | Limited Availability | Manufacturing | 12/12/2025 |
| salbutamol sulfate | Inhalation, conventional | 3 mg | Current | Unavailable | Manufacturing | 11/12/2025 |
| salbutamol sulfate | Inhalation, conventional | 6 mg | Current | Unavailable | Manufacturing | 11/12/2025 |
| salbutamol sulfate | Inhalation | 2.4 mg/mL | Current | Limited Availability | Unexpected increase in demand due to other sponsors unable to supply | 11/12/2025 |
| nortriptyline | Tablet, film coated | 10 mg | Resolved | Available | Manufacturing | 11/12/2025 |
| bisoprolol fumarate | Tablet | 2.5 mg | Current | Unavailable | Manufacturing | 11/12/2025 |
| ondansetron hydrochloride dihydrate | Tablet, film coated | 9.972 mg | Current | Limited Availability | Manufacturing | 11/12/2025 |
| atorvastatin calcium trihydrate | Tablet, film coated | 43.38 mg | Resolved | Available | Manufacturing | 11/12/2025 |
| indapamide hemihydrate | Tablet, sugar coated | 2.5 mg | Current | Unavailable | Manufacturing | 11/12/2025 |
| montelukast sodium | Tablet, chewable | 4.16 mg | Current | Unavailable | Manufacturing | 11/12/2025 |
| enalapril maleate | Tablet | 5 mg | Current | Unavailable | Manufacturing | 11/12/2025 |
| levodopa~carbidopa monohydrate~entacapone | Tablet, film coated | 100 mg~27 mg~200 mg | Current | Unavailable | Unexpected increase in consumer demand | 11/12/2025 |
| ezetimibe | Tablet, uncoated | 10 mg | Current | Limited Availability | Unexpected increase in consumer demand | 11/12/2025 |
| irbesartan | Tablet, film coated | 150 mg | Anticipated | Available | Manufacturing | 11/12/2025 |
| tobramycin | Inhalation, conventional | 60 mg/mL | Anticipated | Available | Manufacturing | 11/12/2025 |
| bimatoprost | Eye Drops | .3 mg/mL | Anticipated | Available | Manufacturing | 11/12/2025 |
| erenumab | Injection, solution | 70 mg | Current | Limited Availability | Unexpected increase in consumer demand | 11/12/2025 |
| crisaborole | Ointment | 2 % w/w | Anticipated | Available | Unexpected increase in consumer demand | 11/12/2025 |
| gabapentin | Tablet, film coated | 600 mg | Resolved | Available | Manufacturing | 11/12/2025 |
| sitagliptin hydrochloride monohydrate~metformin hydrochloride | Tablet, modified release | 56.685 mg~1000 mg | Current | Unavailable | Manufacturing | 11/12/2025 |
| nitrofurantoin | Capsule, hard | 50 mg | Anticipated | Available | Manufacturing | 11/12/2025 |
| Teriparatide | Injection, solution | .25 mg/mL | Anticipated | Available | Manufacturing | 11/12/2025 |
| levothyroxine sodium | Tablet, uncoated | .05 mg | Resolved | Available | Manufacturing | 11/12/2025 |
| rifampicin | Oral Liquid | 20 mg/mL | Anticipated | Available | Unexpected increase in consumer demand | 10/12/2025 |
| metformin hydrochloride | Tablet, film coated | 850 mg | Current | Unavailable | Manufacturing | 10/12/2025 |
| lansoprazole | Capsule, enteric | 30 mg | Current | Limited Availability | Manufacturing | 10/12/2025 |
| lamivudine | Tablet, film coated | 300 mg | Current | Limited Availability | Manufacturing | 10/12/2025 |
| lansoprazole | Tablet, orally disintegrating | 30 mg | Current | Limited Availability | Manufacturing | 10/12/2025 |
| isotretinoin | Capsule, soft | 20 mg | Current | Unavailable | Manufacturing | 10/12/2025 |
| azithromycin | Injection, powder for | 500 mg | Current | Unavailable | Commercial Changes / Commercial viability | 10/12/2025 |
| ropivacaine hydrochloride | Injection, solution | 75 mg | Resolved | Available | Transport / Logistic issues / Storage capacity issues | 10/12/2025 |
| ropivacaine hydrochloride | Injection, solution | 200 mg | Resolved | Available | Transport / Logistic issues / Storage capacity issues | 10/12/2025 |
| lurasidone hydrochloride | Tablet, film coated | 80 mg | Discontinued | Unavailable | Commercial Changes / Commercial viability | 10/12/2025 |
| metformin hydrochloride | Tablet, film coated | 1000 mg | Current | Unavailable | Manufacturing | 10/12/2025 |
| isotretinoin | Capsule, soft | 10 mg | Current | Limited Availability | Manufacturing | 10/12/2025 |
| fluorouracil | Injection, solution | 50 mg/mL | Resolved | Available | Manufacturing | 10/12/2025 |
| doxepin hydrochloride | Capsule, hard | 11.3 mg | Current | Limited Availability | Manufacturing | 10/12/2025 |
| aprepitant | Capsule, hard | 165 mg | Anticipated | Available | Manufacturing | 10/12/2025 |
| montelukast sodium | Tablet, chewable | 5.2 mg | Current | Unavailable | Manufacturing | 10/12/2025 |
| isotretinoin | Capsule, soft | 10 mg | Current | Unavailable | Manufacturing | 10/12/2025 |
| perindopril erbumine | Tablet, uncoated | 2 mg | Discontinued | Unavailable | Commercial Changes / Commercial viability | 10/12/2025 |
| perindopril erbumine | Tablet, uncoated | 4 mg | Discontinued | Unavailable | Commercial Changes / Commercial viability | 10/12/2025 |
| levothyroxine sodium | Tablet, uncoated | 75 microgram | Current | Unavailable | Manufacturing | 10/12/2025 |
| levothyroxine sodium | Tablet, uncoated | 200 microgram | Current | Unavailable | Manufacturing | 10/12/2025 |
| tetrabenazine | Tablet, uncoated | 25 mg | Current | Unavailable | Manufacturing | 10/12/2025 |
| isotretinoin | Capsule, soft | 20 mg | Current | Unavailable | Manufacturing | 10/12/2025 |
| isotretinoin | Capsule, soft | 10 mg | Current | Limited Availability | Manufacturing | 10/12/2025 |
| stannous chloride dihydrate | Injection, powder for | 19.2 microgram/mL | Anticipated | Available | Manufacturing | 10/12/2025 |
| perindopril erbumine | Tablet, uncoated | 8 mg | Discontinued | Unavailable | Commercial Changes / Commercial viability | 10/12/2025 |
| ceftazidime pentahydrate | Injection, powder for | 2.328 g | Resolved | Available | Manufacturing | 9/12/2025 |
| hydromorphone hydrochloride | Injection, solution | 10 mg/mL | Discontinued | Unavailable | Commercial Changes / Commercial viability | 9/12/2025 |
| prasugrel | Tablet, film coated | 5 mg | Resolved | Available | Commercial Changes / Commercial viability | 9/12/2025 |
| dantrolene sodium hemiheptahydrate | Capsule | 25 mg | Current | Unavailable | Manufacturing | 9/12/2025 |
| dantrolene sodium hemiheptahydrate | Capsule | 50 mg | Current | Unavailable | Manufacturing | 9/12/2025 |
| eptifibatide | Injection, solution | 20 mg | Current | Unavailable | Manufacturing | 9/12/2025 |
| mefloquine hydrochloride | Tablet, uncoated | 274.09 mg | Anticipated | Available | Transport / Logistic issues / Storage capacity issues | 9/12/2025 |
| alprostadil | Injection, solution | 500 microgram/mL | Anticipated | Available | Manufacturing | 9/12/2025 |
| labetalol hydrochloride | Tablet, film coated | 100 mg | Resolved | Available | Manufacturing | 9/12/2025 |
| desferrioxamine mesilate | Injection, powder for | 2 g | Anticipated | Available | Manufacturing | 9/12/2025 |
| betiatide | Injection, powder for | 1 mg | Current | Unavailable | Manufacturing | 8/12/2025 |
| drospirenone~ethinylestradiol | Tablet | 3 mg~30 microgram | Resolved | Available | Manufacturing | 8/12/2025 |
| milrinone | Injection, concentrated | 10 mg | Current | Unavailable | Manufacturing | 8/12/2025 |
| temozolomide | Capsule, hard | 20 mg | Anticipated | Available | Manufacturing | 8/12/2025 |
| paclitaxel | Injection, concentrated | 300 mg | Resolved | Available | Manufacturing | 8/12/2025 |
| citalopram hydrobromide | Tablet, film coated | 12.495 mg | Current | Limited Availability | Manufacturing | 8/12/2025 |
| pregabalin | Capsule, hard | 25 mg | Resolved | Available | Manufacturing | 8/12/2025 |
| lamotrigine | Tablet, uncoated | 100 mg | Current | Unavailable | Manufacturing | 8/12/2025 |
| hydrocortisone | Tablet, uncoated | 4 mg | Resolved | Available | Manufacturing | 8/12/2025 |
| levothyroxine sodium | Tablet, uncoated | 100 microgram | Current | Unavailable | Manufacturing | 8/12/2025 |
| levothyroxine sodium | Tablet, uncoated | 50 microgram | Current | Unavailable | Manufacturing | 8/12/2025 |
| thiotepa | Injection, powder for | 15 mg | Current | Unavailable | Commercial Changes / Commercial viability | 8/12/2025 |
| thiotepa | Injection, powder for | 100 mg | Current | Unavailable | Commercial Changes / Commercial viability | 8/12/2025 |
| thiotepa | Injection, powder for | 400 mg | Current | Unavailable | Commercial Changes / Commercial viability | 8/12/2025 |
| clopidogrel hydrogen sulfate | Tablet, film coated | 97.875 mg | Resolved | Available | Unexpected increase in demand due to other sponsors unable to supply | 8/12/2025 |
| tranexamic acid | Tablet, film coated | 500 mg | Current | Limited Availability | Unexpected increase in demand due to other sponsors unable to supply | 8/12/2025 |
| bleomycin sulfate | Injection, powder for | 15000 IU | Resolved | Available | Manufacturing | 8/12/2025 |
| dexamethasone~framycetin sulfate~gramicidin | Ear Drops | .5 mg/mL~5 mg/mL~.05 mg/mL | Current | Limited Availability | Manufacturing | 8/12/2025 |
| pramipexole dihydrochloride monohydrate | Tablet, uncoated | .125 mg | Current | Unavailable | Unexpected increase in demand due to other sponsors unable to supply | 8/12/2025 |
| midazolam | Injection, solution | 1 mg/mL | Current | Unavailable | Manufacturing | 8/12/2025 |
| simvastatin | Tablet, film coated | 5 mg | Current | Limited Availability | Manufacturing | 8/12/2025 |
