海外医薬品不足情報｜医薬政策企画 P-Cubed

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2025.11.25 [ 英国 ]
NICE医薬品情報サービス（2025年11月17日〜2025年11月21日）
Medicine supply notification: Ibandronic acid 150mg tablets

イバンドロン酸150mg錠剤(唯一の認可済み月用ビスホスホネート)は2026年3月まで限定的に供給されています。アレンドロン酸70mg錠剤およびリセドロン酸ナトリウム35mg錠剤(週1回のビスホスホネート投与)は引き続き入手可能で、需要の増加を支えることができます

2025.11.24 [ ドイツ ]

BfArMボトルネック・レポート（2025年11月17日～11月23日）

Active ingredients

Message type

Date of last message

Type of reason

AM designation

Levothyroxine sodium

Initial report

21.11.2025

Production problem

L-thyroxine Aventis 150 microgram tablets

Levothyroxine sodium

Change notification

21.11.2025

Production problem

L-Thyroxine Henning 50

Sevelamer carbonate

Change notification

21.11.2025

Other

Renvela 0.8 g powder for oral suspension – OP(90×842.32mg)

Rizatriptan benzoate

Change notification

21.11.2025

Production problem

Rizatriptan Glenmark 5 mg orodispersible tablets

Moxifloxacin hydrochloride (Ph.Eur.) ((with information on water content (1:x)))

Initial report

20.11.2025

Other

Moxifloxacin Micro Labs 400 mg film-coated tablets

Atorvastatin calcium trihydrate (Ph.Eur.)

Change notification

20.11.2025

Other

Atorvastatin Micro Labs 60 mg film-coated tablets

Atorvastatin calcium trihydrate (Ph.Eur.)

Initial report

20.11.2025

Other

Atorvastatin Micro Labs 40 mg film-coated tablets

Sunitinib

Initial report

20.11.2025

Other

Sunitinib AL 37.5 mg hard capsules

Sunitinib

Initial report

20.11.2025

Other

Sunitinib AL 12.5 mg hard capsules

Atorvastatin calcium trihydrate (Ph.Eur.)

Initial report

20.11.2025

Other

Atorvastatin Micro Labs 30 mg film-coated tablets

Isoniazid

Initial report

20.11.2025

Other

Isozid 100 mg

Diazepam

Initial report

20.11.2025

Other

Diazepam-ratiopharm 10 mg/2 ml solution for injection

Rifampicin sodium

Initial report

20.11.2025

Other

Eremfat i.v. 300mg

Alprazolam

Initial report

20.11.2025

Other

Alprazolam AbZ 0.5 mg tablets

Alprazolam

Initial report

20.11.2025

Other

Alprazolam-ratiopharm 0.5 mg tablets

Trandolapril; verapamil hydrochloride

Change notification

20.11.2025

Other

Tarka 180 mg/2 mg modified-release tablets

Morphine hemisulfate 2.5 hydrate

Initial report

19.11.2025

Production problem

Substitol 30 mg hard capsules, delayed release

Hydromorphone hydrochloride

Change notification

19.11.2025

Production problem

Palladon injection 2 mg

Aprepitant

Change notification

19.11.2025

Other

Aprepitant AL 125 mg and 80 mg hard capsules

Quetiapine fumarate (Ph.Eur.)

Change notification

19.11.2025

Other

Quetiapine AL 300 mg film-coated tablets

Beclomethasone dipropionate (Ph.Eur.)

Change notification

19.11.2025

Other

Beclorhinol aquosum 50 micrograms

Nitrendipine

Change notification

19.11.2025

Other

Nitrendipine AL 20

Vinflunine bis[(R,R)-tartrate]

Change notification

18.11.2025

Production problem

Javlor 25 mg/ml concentrate for solution for infusion – OP(1x2ml)

Chlortalidone

Change notification

18.11.2025

Other

Chlortalidone HEXAL 12.5 mg tablets

Calcium trisodium pentetate (with information on water content, if applicable)

Change notification

18.11.2025

Other

Technescan DTPA

Medium-chain triglycerides; omega-3 acid triglycerides (with information on origin and/or composition); refined soybean oil (Ph.Eur.)

Change notification

18.11.2025

Production problem

Lipidem Emulsion for infusion

Aprepitant

Change notification

18.11.2025

Production problem

Aprepitant STADA 125 mg and 80 mg hard capsules

Aprepitant

Change notification

18.11.2025

Production problem

Aprepitant STADA 80 mg hard capsules

Aprepitant

Change notification

18.11.2025

Production problem

Aprepitant STADA 125 mg hard capsules

Misoprostol

Change notification

17.11.2025

Other

Angusta 25 microgram tablets

Insulin glargine

Initial report

17.11.2025

Other

ABASAGLAR 100 IU/ml solution for injection in pre-filled pen – OP (5x3ml)

Posaconazole

Change notification

17.11.2025

Other

Posaconazole HEXAL 40 mg/ml oral suspension

Lidocaine hydrochloride monohydrate

Change notification

17.11.2025

Other

Xylocaine Gel 2%

Vancomycin hydrochloride

Change notification

17.11.2025

Other

Vancomycin “Lederle” 1000mg

2025.11.24 [ フランス ]

ANSMフランス供給不足情報（2025年11月17日～11月23日）

Active ingredients	Status	Update	Specialty
olanzapine (pamoate) monohydrate	Supply tension	21/11/2025	Zypadhera, powder and solvent for extended-release suspension for injection
risperidone	Supply tension	21/11/2025	Risperidone 0.5 mg, orodispersible tablet
risperidone	Stock shortage	21/11/2025	Risperidone 4 mg orodispersible tablet
risperidone	Stock shortage	21/11/2025	Risperidone 3 mg orodispersible tablet
risperidone	Return to availability	21/11/2025	Risperidone 1 mg and 2 mg, orodispersible tablet
chlorpromazine (hydrochloride)	Stock shortage	20/11/2025	Largactil 100 mg, film-coated tablet
phenylephrine	Stock shortage	19/11/2025	Neosynephrine 10% Faure, eye drops in single-dose container
phenylephrine	Supply tension	19/11/2025	Neosynephrine 10% Faure, eye drops solution
phenylephrine	Supply tension	19/11/2025	Neosynephrine 5% Faure, eye drops solution
methylphenidate (hydrochloride)	Supply tension	19/11/2025	Methylphenidate EG LP, extended-release tablet
ornidazole	Stock shortage	18/11/2025	Tiberal 1 g, solution for injection for infusion
colchicine, opium (powder), tiemonium (methyl sulfate)	Supply tension	18/11/2025	Colchimax, breakable film-coated tablet, and Colchicine Opocalcium 1 mg, breakable tablet
lenalidomide	Stock shortage	18/11/2025	Lenalidomide Mylan, capsule
adrenaline (tartrate)	Return to availability	17/11/2025	Jext 300 micrograms, injectable solution in pre-filled pen

2025.11.24 [ オーストラリア ]

TGAオーストラリア供給不足情報（2025年11月17日～11月23日）

Active ingredients	Dosage form	Quantity of active ingredients	Shortage status	Availability	Reason	Last updated
primidone	Tablet, uncoated	250 mg	Resolved	Available	Manufacturing	21/11/2025
trandolapril	Capsule	2 mg	Current	Unavailable	Unexpected increase in demand due to other sponsors unable to supply	21/11/2025
olanzapine pamoate monohydrate	Injection, powder for	690 mg	Current	Limited Availability	Transport / Logistic issues / Storage capacity issues	21/11/2025
nortriptyline	Tablet, film coated	10 mg	Anticipated	Available	Manufacturing	21/11/2025
lamotrigine	Tablet, chewable	50 mg	Current	Unavailable	Manufacturing	21/11/2025
pramipexole dihydrochloride monohydrate	Tablet	.125 mg	Current	Unavailable	Manufacturing	21/11/2025
pramipexole dihydrochloride monohydrate	Tablet	1 mg	Anticipated	Available	Manufacturing	21/11/2025
ondansetron hydrochloride dihydrate	Tablet, film coated	4.986 mg	Anticipated	Available	Manufacturing	21/11/2025
montelukast sodium	Tablet, chewable	4.16 mg	Current	Unavailable	Manufacturing	21/11/2025
lansoprazole	Tablet, orally disintegrating	15 mg	Current	Limited Availability	Unexpected increase in consumer demand	21/11/2025
quetiapine fumarate	Tablet, modified release	345.39 mg	Current	Limited Availability	Manufacturing	21/11/2025
quetiapine fumarate	Tablet, modified release	460.52 mg	Current	Limited Availability	Manufacturing	21/11/2025
quetiapine fumarate	Tablet, modified release	345.39 mg	Current	Limited Availability	Manufacturing	21/11/2025
mesalazine	Granules, modified release	4 g	Resolved	Available	Transport / Logistic issues / Storage capacity issues	21/11/2025
olmesartan medoxomil~hydrochlorothiazide	Tablet	20 mg~12.5 mg	Current	Limited Availability	Manufacturing	21/11/2025
acamprosate calcium	Tablet, enteric coated	333 mg	Anticipated	Available	Manufacturing	21/11/2025
latanoprost	Eye Drops, solution	.05 mg/mL	Current	Limited Availability	Manufacturing	21/11/2025
latanoprost	Eye Drops, solution	.05 mg/mL	Discontinued	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	21/11/2025
benzathine benzylpenicillin tetrahydrate	Injection, suspension	600000 USP Unit	Current	Unavailable	Manufacturing	21/11/2025
ropinirole hydrochloride	Tablet, film coated	.285 mg	Current	Unavailable	Manufacturing	21/11/2025
paroxetine hydrochloride	Tablet, film coated	22.22 mg	Anticipated	Available	Manufacturing	21/11/2025
lamotrigine	Tablet, chewable	50 mg	Current	Limited Availability	Manufacturing	21/11/2025
lamotrigine	Tablet, chewable	100 mg	Current	Unavailable	Manufacturing	21/11/2025
lamotrigine	Tablet, chewable	200 mg	Current	Unavailable	Manufacturing	21/11/2025
lamotrigine	Tablet, chewable	200 mg	Anticipated	Available	Manufacturing	21/11/2025
betahistine dihydrochloride	Tablet	16 mg	Current	Limited Availability	Manufacturing	21/11/2025
ondansetron hydrochloride dihydrate	Tablet, film coated	4.986 mg	Anticipated	Available	Manufacturing	21/11/2025
Alteplase	Diluent, not applicable	10 mg	Current	Limited Availability	Unexpected increase in consumer demand	21/11/2025
pramipexole dihydrochloride monohydrate	Tablet, uncoated	.125 mg	Current	Limited Availability	Unexpected increase in demand due to other sponsors unable to supply	21/11/2025
desferrioxamine mesilate	Injection, powder for	2 g	Anticipated	Available	Manufacturing	21/11/2025
linezolid	Injection, solution	2 mg/mL	Discontinued	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	21/11/2025
ciprofloxacin hydrochloride	Tablet, film coated	873.32 mg	Current	Unavailable	Manufacturing	21/11/2025
lamotrigine	Tablet, dispersible	100 mg	Current	Limited Availability	Manufacturing	21/11/2025
rifampicin	Oral Liquid	20 mg/mL	Anticipated	Available	Unexpected increase in consumer demand	20/11/2025
imipramine hydrochloride	Tablet, sugar coated	10 mg	Anticipated	Available	Manufacturing	20/11/2025
lidocaine hydrochloride	Gel	20 mg/g	Current	Limited Availability	Manufacturing	20/11/2025
benzathine benzylpenicillin tetrahydrate	Injection, suspension	1200000 USP Unit	Current	Emergency Supply Only	Manufacturing	20/11/2025
ondansetron hydrochloride dihydrate	Injection, solution	10 mg	Current	Limited Availability	Manufacturing	20/11/2025
galantamine hydrobromide	Capsule, modified release	20.512 mg	Current	Limited Availability	Unexpected increase in demand due to other sponsors unable to supply	20/11/2025
galantamine hydrobromide	Capsule, modified release	30.768 mg	Current	Unavailable	Unexpected increase in demand due to other sponsors unable to supply	20/11/2025
temozolomide	Capsule, hard	5 mg	Current	Limited Availability	Manufacturing	20/11/2025
Alteplase	Injection, powder for	50 mg	Resolved	Available	Unexpected increase in consumer demand	20/11/2025
tobramycin	Capsule, hard	28 mg	Current	Emergency Supply Only	Manufacturing	20/11/2025
desvenlafaxine	Tablet, modified release	100 mg	Discontinued	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	20/11/2025
desvenlafaxine	Tablet, modified release	50 mg	Discontinued	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	20/11/2025
entecavir	Tablet, film coated	.5 mg	Current	Unavailable	Manufacturing	20/11/2025
entecavir	Tablet, film coated	1 mg	Current	Limited Availability	Manufacturing	20/11/2025
armodafinil	Tablet, uncoated	250 mg	Current	Limited Availability	Transport / Logistic issues / Storage capacity issues	20/11/2025
rifampicin	Capsule	150 mg	Current	Emergency Supply Only	Manufacturing	20/11/2025
rifampicin	Capsule	300 mg	Current	Limited Availability	Manufacturing	20/11/2025
atomoxetine hydrochloride	Capsule, hard	20.57 mg	Anticipated	Available	Manufacturing	20/11/2025
hydroxocobalamin acetate	Injection, solution	1.044 mg	Anticipated	Available	Unexpected increase in consumer demand	20/11/2025
doxepin hydrochloride	Capsule, hard	11.3 mg	Current	Limited Availability	Manufacturing	20/11/2025
levodopa~carbidopa monohydrate	Tablet, uncoated	100 mg~27 mg	Resolved	Available	Manufacturing	20/11/2025
deferasirox	Tablet, film coated	90 mg	Current	Limited Availability	Manufacturing	20/11/2025
deferasirox	Tablet, film coated	360 mg	Current	Unavailable	Manufacturing	20/11/2025
escitalopram oxalate	Tablet, film coated	25.548 mg	Current	Limited Availability	Manufacturing	20/11/2025
ropivacaine hydrochloride	Injection, solution	7.5 mg/mL	Current	Limited Availability	Manufacturing	20/11/2025
ropivacaine hydrochloride	Injection, solution	7.5 mg/mL	Current	Unavailable	Manufacturing	20/11/2025
ropivacaine hydrochloride	Injection, solution	2 mg/mL	Anticipated	Available	Manufacturing	20/11/2025
olanzapine	Tablet, film coated	5 mg	Resolved	Available	Transport / Logistic issues / Storage capacity issues	20/11/2025
dosulepin hydrochloride	Tablet, film coated	75 mg	Current	Limited Availability	Manufacturing	20/11/2025
olanzapine	Wafer	5 mg	Current	Unavailable	Transport / Logistic issues / Storage capacity issues	20/11/2025
risperidone	Injection, modified release	50 mg	Current	Limited Availability	Manufacturing	20/11/2025
nizatidine	Capsule	300 mg	Current	Limited Availability	Manufacturing	20/11/2025
perindopril erbumine~indapamide hemihydrate	Tablet, uncoated	4 mg~1.25 mg	Discontinued	Unavailable	Commercial Changes / Commercial viability	20/11/2025
sertraline hydrochloride	Tablet, film coated	55.96 mg	Resolved	Available	Manufacturing	19/11/2025
minoxidil	Tablet, uncoated	10 mg	Current	Limited Availability	Manufacturing	19/11/2025
pramipexole dihydrochloride monohydrate	Tablet	.25 mg	Current	Unavailable	Manufacturing	19/11/2025
pregabalin	Capsule, hard	25 mg	Current	Limited Availability	Manufacturing	19/11/2025
hydrochlorothiazide~olmesartan medoxomil	Tablet	12.5 mg~40 mg	Current	Limited Availability	Manufacturing	19/11/2025
sacubitril~valsartan	Tablet, film coated	97.2 mg~102.8 mg	Current	Unavailable	Manufacturing	19/11/2025
tetrabenazine	Tablet, uncoated	25 mg	Current	Unavailable	Manufacturing	19/11/2025
chlorhexidine gluconate~cetrimide	Solution, irrigation	15 mg~150 mg	Anticipated	Available	Manufacturing	19/11/2025
chlorhexidine gluconate~cetrimide	Solution, irrigation	4.5 mg~45 mg	Anticipated	Available	Manufacturing	19/11/2025
betiatide	Injection, powder for	1 mg	Current	Unavailable	Manufacturing	18/11/2025
phenytoin sodium	Injection, solution	250 mg	Current	Limited Availability	Manufacturing	18/11/2025
phenytoin sodium	Injection, solution	100 mg	Current	Unavailable	Manufacturing	18/11/2025
olanzapine	Tablet, orally disintegrating	5 mg	Current	Unavailable	Manufacturing	18/11/2025
ropivacaine hydrochloride	Injection, solution	2 mg/mL	Discontinued	Unavailable	Commercial Changes / Commercial viability	18/11/2025
ropivacaine hydrochloride	Injection, solution	2 mg/mL	Discontinued	Unavailable	Commercial Changes / Commercial viability	18/11/2025
atorvastatin calcium trihydrate~amlodipine besilate	Tablet, film coated	43.376 mg~6.94 mg	Resolved	Available	Manufacturing	18/11/2025
hydromorphone hydrochloride	Injection, solution	10 mg/mL	Discontinued	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	18/11/2025
Tocilizumab	Injection, solution	162 mg	Anticipated	Available	Manufacturing	18/11/2025
phenytoin sodium	Injection, solution	100 mg	Discontinued	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	18/11/2025
phenytoin sodium	Injection, solution	250 mg	Current	Limited Availability	Manufacturing	18/11/2025
dinoprostone	Gel	.3333 mg/g	Current	Emergency Supply Only	Manufacturing	18/11/2025
dinoprostone	Gel	.6667 mg/g	Current	Emergency Supply Only	Manufacturing	18/11/2025
flecainide acetate	Injection, solution	10 mg/mL	Current	Unavailable	Transport / Logistic issues / Storage capacity issues	17/11/2025
prazosin hydrochloride	Tablet, uncoated	1.095 mg	Resolved	Available	Unexpected increase in demand due to other sponsors unable to supply	17/11/2025
prazosin hydrochloride	Tablet, uncoated	5.476 mg	Anticipated	Available	Unexpected increase in demand due to other sponsors unable to supply	17/11/2025
tobramycin	Injection, solution	80 mg	Anticipated	Available	Manufacturing	17/11/2025
mupirocin	Ointment	22 mg/g	Resolved	Available	Unexpected increase in consumer demand	17/11/2025
glimepiride	Tablet, uncoated	1 mg	Current	Unavailable	Manufacturing	17/11/2025
risperidone	Tablet, film coated	3 mg	Current	Unavailable	Manufacturing	17/11/2025
pramipexole dihydrochloride monohydrate	Tablet	.125 mg	Current	Unavailable	Manufacturing	17/11/2025
galantamine hydrobromide	Capsule, modified release	10.252 mg	Current	Unavailable	Manufacturing	17/11/2025
galantamine hydrobromide	Capsule, modified release	10.252 mg	Current	Unavailable	Manufacturing	17/11/2025
galantamine hydrobromide	Capsule, modified release	20.504 mg	Current	Unavailable	Manufacturing	17/11/2025
galantamine hydrobromide	Capsule, modified release	20.504 mg	Current	Unavailable	Manufacturing	17/11/2025
tranexamic acid	Injection, solution	1000 mg	Current	Unavailable	Commercial Changes / Commercial viability	17/11/2025
pramipexole dihydrochloride monohydrate	Tablet	1 mg	Resolved	Available	Manufacturing	17/11/2025
flecainide acetate	Tablet, uncoated	50 mg	Anticipated	Available	Manufacturing	17/11/2025
bimatoprost	Eye Drops	.3 mg/mL	Current	Unavailable	Manufacturing	17/11/2025
anastrozole	Tablet, film coated	1 mg	Resolved	Available	Manufacturing	17/11/2025
tenofovir disoproxil maleate~efavirenz~emtricitabine	Tablet, film coated	300 mg~600 mg~200 mg	Current	Unavailable	Manufacturing	17/11/2025
escitalopram oxalate	Tablet, film coated	12.74 mg	Current	Unavailable	Commercial Changes / Commercial viability	17/11/2025
escitalopram oxalate	Tablet, film coated	25.47 mg	Current	Limited Availability	Manufacturing	17/11/2025
ambrisentan	Tablet, film coated	10 mg	Current	Limited Availability	Manufacturing	17/11/2025
risperidone	Tablet, film coated	1 mg	Anticipated	Available	Manufacturing	17/11/2025
dimethyl fumarate	Capsule, enteric	240 mg	Anticipated	Available	Manufacturing	17/11/2025
fingolimod hydrochloride	Capsule	560 microgram	Current	Limited Availability	Manufacturing	17/11/2025
oseltamivir phosphate	Capsule, hard	98.524 mg	Current	Limited Availability	Manufacturing	17/11/2025
lamotrigine	Tablet, chewable	100 mg	Current	Unavailable	Manufacturing	17/11/2025
rivaroxaban	Tablet, film coated	10 mg	Resolved	Available	Manufacturing	17/11/2025
rivaroxaban	Tablet, film coated	15 mg	Current	Limited Availability	Manufacturing	17/11/2025
sitagliptin hydrochloride monohydrate~metformin hydrochloride	Tablet, modified release	56.685 mg~1000 mg	Current	Unavailable	Manufacturing	17/11/2025
nitrofurantoin	Capsule, hard	50 mg	Anticipated	Available	Manufacturing	17/11/2025
patisiran sodium	Injection, concentrated	10.5 mg	Discontinued	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	17/11/2025
bleomycin sulfate	Injection, powder for	15000 IU	Current	Emergency Supply Only	Manufacturing	17/11/2025
bumetanide	Tablet, uncoated	1 mg	Resolved	Available	Manufacturing	17/11/2025
ethinylestradiol~norethisterone	Tablet, uncoated	36 microgram~500 microgram	Current	Limited Availability	Manufacturing	17/11/2025
voriconazole	Injection, powder for	200 mg	Discontinued	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	17/11/2025
galantamine hydrobromide~galantamine	Capsule, modified release	20.51 mg~16 mg	Current	Limited Availability	Unexpected increase in demand due to other sponsors unable to supply	17/11/2025

2025.11.24 [ 米国 ]

ASHP供給不足情報（2025年11月17日～11月23日）

Generic Name	Shortage Status	Revision Date
Amoxicillin Oral Presentations	Current Shortages	21-Nov-25
Dextroamphetamine Extended-Release Capsules	Current Shortages	21-Nov-25
Lanthanum Carbonate Oral Presentations	Current Shortages	21-Nov-25
Liraglutide Injection	Current Shortages	21-Nov-25
Lorazepam Tablets	Current Shortages	21-Nov-25
Oxacillin Sodium Injection	Current Shortages	21-Nov-25
Bivalirudin Injection	Current Shortages	20-Nov-25
Epinephrine Auto-Injectors	Current Shortages	20-Nov-25
Haloperidol Lactate Injection	Current Shortages	20-Nov-25
Cromolyn Oral Solution	Current Shortages	19-Nov-25
Mercaptopurine Tablets	Current Shortages	19-Nov-25
Carboplatin Solution for Injection	Current Shortages	18-Nov-25
Dronabinol Capsules	Current Shortages	18-Nov-25
Erythromycin Lactobionate Injection	Current Shortages	18-Nov-25
Potassium Chloride Injection	Current Shortages	18-Nov-25
Quinapril Tablets	Current Shortages	18-Nov-25
Sterile Water for Irrigation	Current Shortages	18-Nov-25
Succinylcholine Injection	Current Shortages	18-Nov-25
50% Dextrose Injection	Resolved Shortages	17-Nov-25
Ascorbic Acid Injection	Current Shortages	17-Nov-25
Budesonide Suspension for Inhalation	Current Shortages	17-Nov-25
Chlorothiazide Oral Suspension	Current Shortages	17-Nov-25
Cisplatin Injection	Current Shortages	17-Nov-25
Clindamycin Phosphate Injection	Current Shortages	17-Nov-25
Dimenhydrinate Injection	Current Shortages	17-Nov-25
Rocuronium Injection	Current Shortages	17-Nov-25
Ropivacaine Injection	Current Shortages	17-Nov-25
Triamcinolone Hexacetonide Injection	Current Shortages	17-Nov-25