プロプラノロール80mgのM/Rカプセルは2026年3月初旬まで在庫切れ、160mgのM/Rカプセルは2026年11月下旬から1月中旬から下旬まで在庫切れです。I/Rの40mgおよび80mgのタブがあり、需要の増加にも対応できます。経口用溶液は利用可能ですが、需要の増加には対応できません
| Active ingredients |
| Date of last message | Type of reason | AM designation | |
| Hydromorphone hydrochloride | Initial report | 14.11.2025 | Production problem | Palladon inject 2 mg | |
| Sevelamer carbonate | Initial report | 14.11.2025 | Other | Renvela 0.8 g powder for oral suspension – OP(90×842.32mg) | |
| Pirfenidone | Change notification | 14.11.2025 | Production problem | Pirfenidone Accord 801 mg film-coated tablets | |
| Dinoprostone | Initial report | 14.11.2025 | Other | Minprostin E2 vaginal gel 2 mg | |
| Dinoprostone | Initial report | 14.11.2025 | Other | Minprostin E2 vaginal gel 1 mg | |
| Sertraline hydrochloride | Change notification | 14.11.2025 | Other | Sertraline TAD 100 mg film-coated tablets | |
| Sertraline hydrochloride | Change notification | 14.11.2025 | Other | Sertraline TAD 50 mg film-coated tablets | |
| Methyldopa (Ph.Eur.) | Change notification | 14.11.2025 | Other | Dopegyt tablets | |
| Quetiapine fumarate (Ph.Eur.) | Change notification | 14.11.2025 | Other | Seroquel Prolong 150 mg prolonged-release tablets | |
| Trandolapril; verapamil hydrochloride | Change notification | 13.11.2025 | Other | Tarka 240 mg/4 mg modified-release tablets | |
| Posaconazole | Change notification | 13.11.2025 | Other | Posaconazole AL 40 mg/ml oral suspension | |
| Methylphenidate hydrochloride | Change notification | 13.11.2025 | Other | Metiphenal 10 mg modified-release hard capsules | |
| Quetiapine fumarate (Ph.Eur.) | Change notification | 13.11.2025 | Other | Quetiapine AL 150 mg prolonged-release tablets | |
| Proxymetacaine hydrochloride | Initial report | 12.11.2025 | Production problem | Proparacaine-POS 0.5% | |
| Quetiapine fumarate (Ph.Eur.) | Change notification | 12.11.2025 | Other | Seroquel Prolong 50 mg prolonged-release tablets | |
| Tamsulosin hydrochloride | Initial report | 12.11.2025 | Other | Tamsulosin hydrochloride PUREN 0.4 mg prolonged-release capsules | |
| Pregabalin | Change notification | 12.11.2025 | Other | Pregabalin Aurobindo 25 mg hard capsules | |
| Ibuprofen | Initial report | 12.11.2025 | Production problem | Ibuprofen PUREN 600 mg film-coated tablets | |
| Gabapentin | Initial report | 12.11.2025 | Other | Gabapentin Aurobindo 600 mg film-coated tablets | |
| Urapidil | Initial report | 12.11.2025 | Other | Urapidil PUREN 60 mg prolonged-release capsules | |
| Urapidil | Initial report | 12.11.2025 | Other | Urapidil PUREN 30 mg prolonged-release capsules | |
| Fentanyl | Change notification | 12.11.2025 | Production problem | Fentanyl PUREN 25 micrograms/h transdermal patch | |
| Lamotrigine | Initial report | 12.11.2025 | Production problem | Lamotrigine Aurobindo 5 mg tablets for oral suspension | |
| Rizatriptan benzoate | Change notification | 12.11.2025 | Production problem | Rizatriptan PUREN 5 mg tablets | |
| Sitagliptin hydrochloride monohydrate | Initial report | 12.11.2025 | Other | Sitagliptin PUREN 25 mg film-coated tablets | |
| Gemcitabine hydrochloride | Initial report | 12.11.2025 | Other | Gemcitabine Aurobindo 40 mg/ml concentrate for solution for infusion | |
| Mesalazine | Change notification | 12.11.2025 | Production problem | Claversal Micropellets 1.5 g | |
| Risperidone | Initial report | 12.11.2025 | Other | Risperidone PUREN 3 mg film-coated tablets | |
| Risperidone | Initial report | 12.11.2025 | Other | Risperidone PUREN 0.5 mg film-coated tablets | |
| Mesalazine | Initial report | 12.11.2025 | Other | Claversal 500 mg tablets | |
| Propranolol hydrochloride | Initial report | 12.11.2025 | Other | Propranolol PUREN 10 mg film-coated tablets | |
| Buprenorphine hydrochloride | Initial report | 12.11.2025 | Other | Buprenorphine PUREN 8 mg sublingual tablets | |
| Oxycodone hydrochloride (Ph.Eur.) | Initial report | 12.11.2025 | Other | Oxycodone hydrochloride Puren 10 mg prolonged-release tablets | |
| Levetiracetam | Initial report | 12.11.2025 | Other | Levetiracetam PUREN 1000 mg film-coated tablets | |
| Levetiracetam | Initial report | 12.11.2025 | Other | Levetiracetam Aurobindo 1000 mg film-coated tablets | |
| Lamotrigine | Initial report | 12.11.2025 | Other | Lamotrigine Aurobindo 25 mg tablets | |
| Efavirenz; emtricitabine; tenofovir disoproxil fumarate | Initial report | 12.11.2025 | Other | Efavirenz/emtricitabine/tenofovir disoproxil PUREN 600 mg/200 mg/245 mg film-coated tablets | |
| Linezolid | Initial report | 12.11.2025 | Other | Linezolid PUREN 600 mg film-coated tablets | |
| Risperidone | Initial report | 12.11.2025 | Other | Risperidone Aurobindo 1 mg film-coated tablets | |
| Olanzapine embonate monohydrate | Initial report | 11.11.2025 | Production problem | ZYPADHERA 405 mg powder and solvent for the preparation of a depot injection suspension – OP(931mg+3ml) | |
| Aprepitant | Change notification | 11.11.2025 | Other | Aprepitant AL 125 mg hard capsules | |
| Oxazepam | Change notification | 11.11.2025 | Other | Oxazepam AL 10 | |
| Ciprofloxacin hydrochloride (1:1) 1 H<2>O | Change notification | 11.11.2025 | Other | Ciprohexal 100 mg | |
| Ciprofloxacin hydrochloride (1:1) 1 H<2>O | Change notification | 11.11.2025 | Other | Cipro-1 A Pharma 100mg | |
| Terbutaline sulfate (Ph.Eur.) | Change notification | 11.11.2025 | Production problem | BRICANYL 0.5 mg | |
| Nimodipine | Change notification | 10.11.2025 | Other | Nimodipine Hexal 30mg | |
| Insulin lispro | Initial report | 10.11.2025 | Other | Liprolog 100 E/ml solution for injection in cartridge – OP[2x(5x3ml)] | |
| Human insulin (with manufacturing details) | Initial report | 10.11.2025 | Other | Huminsulin Normal KwikPen 100 IU/ml solution for injection | |
| Calcium trisodium pentetate (with information on water content, if applicable) | Initial report | 10.11.2025 | Other | Technescan DTPA | |
| Sevelamer | Change notification | 10.11.2025 | Other | Renagel 800 mg film-coated tablets – OP(1×180) | |
| Tenofovir disoproxil fumarate | Initial report | 10.11.2025 | Other | Tenofovir disoproxil PUREN 245 mg film-coated tablets | |
| Lidocaine | Initial report | 10.11.2025 | Other | XYLOCAIN PUMP SPRAY | |
| Vinflunine bis[(R,R)-tartrate] | Initial report | 10.11.2025 | Production problem | Javlor 25 mg/ml concentrate for solution for infusion – OP (1x2ml) | |
| Ipratropium bromide (Ph.Eur.); salbutamol sulfate | Change notification | 10.11.2025 | Production problem | Ipratropium/salbutamol Cipla 0.5 mg/2.5 mg solution for nebulizer | |
| Valsartan | Initial report | 10.11.2025 | Production problem | Valsartan STADA 80 mg film-coated tablets | |
| Valsartan | Initial report | 10.11.2025 | Production problem | Valsartan STADA 160 mg film-coated tablets | |
| Aprepitant | Initial report | 10.11.2025 | Other | EMEND 125 mg powder for oral suspension – OPXXXXmg | |
| Amikacin sulfate | Change notification | 10.11.2025 | Production problem | Amikacin B. Braun 2.5 mg/ml solution for infusion | |
| Amikacin sulfate | Change notification | 10.11.2025 | Production problem | Amikacin B. Braun 5 mg/ml solution for infusion | |
| Tolterodine tartrate | Change notification | 10.11.2025 | Other | Detrusitol 2 mg film-coated tablets | |
| Ipratropium bromide | Change notification | 10.11.2025 | Production problem | Ipratropium bromide 125 micrograms/1 ml Stulln | |
| Duloxetine hydrochloride | Initial report | 10.11.2025 | Other | Cymbalta 60 mg gastro-resistant hard capsules – OP28 |
| Active ingredients | Status | Update | Specialty |
| dopamine (hydrochloride) | Supply tension | 14/11/2025 | Dopamine Viatris 40 mg/mL, solution for infusion |
| dipotassium clorazepate | Stock shortage | 14/11/2025 | Tranxene 20 mg/2 mL, lyophilisate and solution for parenteral use |
| cyamemazine | Stock shortage | 14/11/2025 | Tercian 50 mg/5 mL, injectable solution in ampoule |
| temozolomide | Return to availability | 14/11/2025 | Temodal 2.5 mg/mL, powder for solution for infusion |
| propofol | Return to availability | 14/11/2025 | Diprivan 20 mg/mL, injectable emulsion in pre-filled syringe |
| propofol | Return to availability | 14/11/2025 | Diprivan 10 mg/mL, injectable emulsion in pre-filled syringe |
| megestrol (acetate) | Stock shortage | 13/11/2025 | Megace 160 mg, tablet |
| methylphenidate (hydrochloride) | Supply tension | 13/11/2025 | Methylphenidate EG LP 18 mg and 36 mg, extended-release tablet |
| fluorouracil | Supply tension | 13/11/2025 | Fluorouracil Pfizer 50 mg/mL, solution for dilution for infusion – 20 mL and 100 mL vials |
| valproic acid, sodium (valproate) | Supply tension | 13/11/2025 | Micropakine L.P., extended-release granules in single-dose sachets |
| tolvaptan | Stock shortage | 10/11/2025 | Tolvaptan Biogaran 15 mg, tablet + Tolvaptan Biogaran 45 mg, tablet – |
| tolvaptan | Stock shortage | 10/11/2025 | Tolvaptan Teva 15 mg tablet + Tolvaptan Teva 45 mg tablet |
| Active ingredients | Dosage form | Quantity of active ingredients | Shortage status | Availability | Reason | Last updated |
| atracurium besilate | Injection, intravenous infusion | 10 mg/mL | Current | Unavailable | Manufacturing | 14/11/2025 |
| lamotrigine | Tablet, chewable | 100 mg | Current | Unavailable | Manufacturing | 14/11/2025 |
| bisoprolol fumarate | Tablet | 5 mg | Current | Limited Availability | Manufacturing | 14/11/2025 |
| bisoprolol fumarate | Tablet | 10 mg | Current | Limited Availability | Manufacturing | 14/11/2025 |
| atorvastatin calcium trihydrate | Tablet, film coated | 21.69 mg | Current | Unavailable | Manufacturing | 14/11/2025 |
| atorvastatin calcium trihydrate~amlodipine besilate | Tablet, film coated | 43.376 mg~13.88 mg | Resolved | Available | Manufacturing | 14/11/2025 |
| quetiapine fumarate | Tablet, modified release | 345.39 mg | Current | Limited Availability | Manufacturing | 14/11/2025 |
| linezolid | Tablet, film coated | 600 mg | Current | Unavailable | Manufacturing | 14/11/2025 |
| amlodipine besilate~olmesartan medoxomil | Tablet, film coated | 6.935 mg~20 mg | Anticipated | Available | Manufacturing | 14/11/2025 |
| pregabalin | Capsule, hard | 300 mg | Resolved | Available | Manufacturing | 14/11/2025 |
| hydrochlorothiazide~olmesartan medoxomil~amlodipine besilate | Tablet, film coated | 12.5 mg~40 mg~13.9 mg | Current | Unavailable | Manufacturing | 14/11/2025 |
| lamotrigine | Tablet, chewable | 50 mg | Anticipated | Available | Manufacturing | 14/11/2025 |
| flecainide acetate | Tablet | 50 mg | Resolved | Available | Manufacturing | 14/11/2025 |
| tofacitinib citrate | Solution | 1.62 mg/mL | Anticipated | Available | Manufacturing | 14/11/2025 |
| mivacurium chloride | Injection, solution | 2.14 mg/mL | Current | Unavailable | Manufacturing | 14/11/2025 |
| rifampicin | Capsule, hard | 300 mg | Current | Emergency Supply Only | Manufacturing | 14/11/2025 |
| benzathine benzylpenicillin tetrahydrate | Injection, suspension | 1200000 USP Unit | Current | Emergency Supply Only | Manufacturing | 13/11/2025 |
| ropivacaine hydrochloride | Injection, solution | 75 mg | Current | Unavailable | Transport / Logistic issues / Storage capacity issues | 13/11/2025 |
| escitalopram oxalate | Tablet, film coated | 12.774 mg | Discontinued | Reduction in supply until supply is exhausted | Commercial Changes / Commercial viability | 13/11/2025 |
| escitalopram oxalate | Tablet, film coated | 25.548 mg | Discontinued | Reduction in supply until supply is exhausted | Commercial Changes / Commercial viability | 13/11/2025 |
| acarbose | Tablet | 100 mg | Resolved | Available | Manufacturing | 13/11/2025 |
| irbesartan | Tablet, film coated | 300 mg | Anticipated | Available | Manufacturing | 13/11/2025 |
| irbesartan | Tablet, film coated | 150 mg | Anticipated | Available | Manufacturing | 13/11/2025 |
| bimatoprost | Eye Drops | .3 mg/mL | Anticipated | Available | Manufacturing | 13/11/2025 |
| escitalopram oxalate | Tablet, film coated | 12.774 mg | Anticipated | Available | Manufacturing | 13/11/2025 |
| nitrofurantoin | Capsule, hard | 100 mg | Current | Unavailable | Unexpected increase in consumer demand | 13/11/2025 |
| mitomycin | Injection, powder for | 20 mg | Current | Limited Availability | Manufacturing | 13/11/2025 |
| tobramycin | Injection, solution | 40 mg/mL | Discontinued | Reduction in supply until supply is exhausted | Commercial Changes / Commercial viability | 13/11/2025 |
| ephedrine sulfate | Injection, solution | 30 mg/mL | Resolved | Available | Manufacturing | 12/11/2025 |
| clopidogrel hydrogen sulfate | Tablet, film coated | 97.875 mg | Resolved | Available | Unexpected increase in consumer demand | 12/11/2025 |
| mesalazine | Granules, modified release | 4 g | Current | Limited Availability | Transport / Logistic issues / Storage capacity issues | 12/11/2025 |
| levetiracetam | Solution | 100 mg/mL | Current | Limited Availability | Manufacturing | 12/11/2025 |
| tranexamic acid | Tablet, film coated | 500 mg | Current | Limited Availability | Manufacturing | 12/11/2025 |
| atorvastatin calcium trihydrate | Tablet, film coated | 86.76 mg | Resolved | Available | Manufacturing | 12/11/2025 |
| metformin hydrochloride | Tablet, film coated | 1000 mg | Current | Unavailable | Unexpected increase in consumer demand | 12/11/2025 |
| lacosamide | Tablet, film coated | 100 mg | Current | Limited Availability | Manufacturing | 12/11/2025 |
| lacosamide | Tablet, film coated | 50 mg | Current | Limited Availability | Manufacturing | 12/11/2025 |
| montelukast sodium | Tablet, chewable | 5.2 mg | Current | Unavailable | Manufacturing | 12/11/2025 |
| isotretinoin | Capsule, soft | 10 mg | Current | Unavailable | Manufacturing | 12/11/2025 |
| adrenaline (epinephrine) | Injection, solution | 500 microgram | Current | Unavailable | Manufacturing | 12/11/2025 |
| daptomycin | Injection, powder for | 500 mg | Current | Unavailable | Manufacturing | 12/11/2025 |
| daptomycin | Inhalation, powder for | 350 mg | Current | Unavailable | Manufacturing | 12/11/2025 |
| spironolactone | Tablet, film coated | 25 mg | Anticipated | Available | Unexpected increase in demand due to other sponsors unable to supply | 12/11/2025 |
| flunitrazepam | Tablet, film coated | 1 mg | Current | Limited Availability | Manufacturing | 12/11/2025 |
| dienogest~ethinylestradiol | Tablet, sugar coated | 2 mg~.03 mg | Discontinued | Reduction in supply until supply is exhausted | Manufacturing | 11/11/2025 |
| nortriptyline | Tablet, film coated | 10 mg | Anticipated | Available | Manufacturing | 11/11/2025 |
| insulin | Injection, suspension | 100 IU/mL | Discontinued | Reduction in supply until supply is exhausted | Commercial Changes / Commercial viability | 11/11/2025 |
| insulin | Injection, solution | 100 IU/mL | Discontinued | Reduction in supply until supply is exhausted | Commercial Changes / Commercial viability | 11/11/2025 |
| doxylamine succinate | Tablet, uncoated | 25 mg | Resolved | Available | Unexpected increase in consumer demand | 11/11/2025 |
| milrinone | Injection, concentrated | 10 mg | Current | Unavailable | Manufacturing | 11/11/2025 |
| lamotrigine | Tablet, uncoated | 100 mg | Current | Limited Availability | Manufacturing | 11/11/2025 |
| prasugrel | Tablet, film coated | 5 mg | Current | Unavailable | Commercial Changes / Commercial viability | 11/11/2025 |
| insulin | Injection, suspension | 100 IU/mL | Discontinued | Reduction in supply until supply is exhausted | Commercial Changes / Commercial viability | 11/11/2025 |
| Insulin lispro | Injection, solution | 100 IU/mL | Discontinued | Reduction in supply until supply is exhausted | Commercial Changes / Commercial viability | 11/11/2025 |
| cisatracurium besilate | Injection, solution | 2.68 mg/mL | Current | Unavailable | Manufacturing | 11/11/2025 |
| vinorelbine tartrate | Injection, concentrated | 13.85 mg/mL | Discontinued | Unavailable | Commercial Changes / Commercial viability | 11/11/2025 |
| sertraline hydrochloride | Tablet, film coated | 55.96 mg | Current | Unavailable | Manufacturing | 10/11/2025 |
| olanzapine pamoate monohydrate | Injection, powder for | 690 mg | Current | Unavailable | Transport / Logistic issues / Storage capacity issues | 10/11/2025 |
| bethanechol chloride | Tablet, uncoated | 10 mg | Discontinued | Reduction in supply until supply is exhausted | Commercial Changes / Commercial viability | 10/11/2025 |
| riluzole | Tablet, film coated | 50 mg | Anticipated | Available | Manufacturing | 10/11/2025 |
| cyproterone acetate | Tablet, uncoated | 50 mg | Current | Unavailable | Manufacturing | 10/11/2025 |
| cyproterone acetate | Tablet, uncoated | 100 mg | Anticipated | Available | Manufacturing | 10/11/2025 |
| ambrisentan | Tablet, film coated | 10 mg | Anticipated | Available | Manufacturing | 10/11/2025 |
| acamprosate calcium | Tablet, enteric coated | 333 mg | Anticipated | Available | Manufacturing | 10/11/2025 |
| paroxetine hydrochloride | Tablet, film coated | 22.22 mg | Anticipated | Available | Manufacturing | 10/11/2025 |
| hyoscine butylbromide | Injection, solution | 20 mg | Resolved | Available | Manufacturing | 10/11/2025 |
| ondansetron hydrochloride dihydrate | Tablet, film coated | 4.986 mg | Anticipated | Available | Manufacturing | 10/11/2025 |
| isotretinoin | Capsule, soft | 10 mg | Anticipated | Available | Manufacturing | 10/11/2025 |
| rifampicin | Capsule, hard | 150 mg | Current | Limited Availability | Manufacturing | 10/11/2025 |
