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2025.07.14 [ ドイツ ]

BfArMボトルネック・レポート（2025年7月7日～7月13日）

Active ingredients

Report type

Date of last message

Type of reason

AM designation

Methyl (5-amino-4-oxopentanoate) hydrochloride

Initial report

11.07.2025

Other

Metvix 160 mg/g cream

Semaglutide

Initial report

11.07.2025

Other

Ozempic 1 mg injection solution in a pre-filled pen – OP(3x3ml)

Salbutamol sulfate

Change notification

11.07.2025

Other

Sultanol inhalation solution

Salbutamol sulfate

Change notification

11.07.2025

Other

Sultanol metered aerosol

Flunisolid hemihydrate

Change notification

11.07.2025

Other

Syntaris

Framycetin sulfate (Ph.Eur.)

Change notification

11.07.2025

Other

Leukase N ointment

Human insulin (with manufacturing details); Isophane insulin suspension for injection (Ph.Eur.)

Initial report

11.07.2025

Other

Actraphane 30 FlexPen 100 IU/ml injection suspension in injector – OP(10x3ml)

Insulin aspart

Initial report

11.07.2025

Other

NovoMix 30 FlexPen 100 IU/ml injection suspension in pre-filled syringe – OP(10x3ml)

Promethazine hydrochloride

Initial report

11.07.2025

Production problem

Atosil injection solution N

Paliperidone palmitate

Initial report

11.07.2025

Other

XEPLION 50 mg depot injection suspension – OP1ml

Paliperidone palmitate

Initial report

11.07.2025

Other

XEPLION 25 mg depot injection suspension – OP1ml

Ampicillin sodium

Initial report

10.07.2025

Production problem

Ampicillin Eberth 1 g powder for solution for injection/infusion

Trometamol

Initial report

10.07.2025

Other

Tham-Köhler

Trometamol

Initial report

10.07.2025

Other

THAM-Köhler 3 M

Atorvastatin calcium trihydrate (Ph.Eur.)

Change notification

10.07.2025

Other

Atorvastatin Aristo 60 mg film-coated tablets

Cinacalcet hydrochloride

Initial report

10.07.2025

Other

Cinacalcet Mylan 60 mg film-coated tablets – OP(28×1)

Pramipexole dihydrochloride monohydrate

Change notification

10.07.2025

Other

Pramipexole Mylan 0.52 mg prolonged-release tablets

Pramipexole dihydrochloride monohydrate

Change notification

10.07.2025

Other

Pramipexole Mylan 0.26 mg prolonged-release tablets

Trandolapril; verapamil hydrochloride

Change notification

10.07.2025

Production problem

Tarka 240 mg/2 mg modified-release tablets

Sufentanil citrate

Initial report

10.07.2025

Production problem

Sufenta 50 micrograms/ml solution for injection

Deferasirox

Change notification

10.07.2025

Other

Deferasirox Mylan 180 mg film-coated tablets

Potassium canrenoate

Change notification

10.07.2025

Production problem

Aldactone 10 ml Canrenoate

Oxazepam

Change notification

10.07.2025

Other

Oxazepam AL 10

Amoxicillin trihydrate

Change notification

10.07.2025

Other

Amoxicillin AL TS

Isophane insulin suspension for injection (Ph.Eur.)

Change notification

09.07.2025

Other

Protaphane FlexPen 100 IU/ml injection suspension in injector – OP (10x3ml)

Estriol

Initial report

09.07.2025

Other

Ovestin 1 mg cream

Propofol

Initial report

09.07.2025

Other

DISOPRIVAN 1%

Lidocaine hydrochloride monohydrate

Initial report

09.07.2025

Other

Xylocaine Gel 2%

Azathioprine

Initial report

09.07.2025

Other

Imurek 25 mg film-coated tablets

Levothyroxine sodium (Ph.Eur.)

Initial report

09.07.2025

Other

Thevier 100

Levothyroxine sodium (Ph.Eur.)

Initial report

09.07.2025

Other

Thevier 50

Methylphenidate hydrochloride

Initial report

09.07.2025

Other

Methylphenidate-ratiopharm 20 mg modified-release hard capsules

Methylphenidate hydrochloride

Initial report

09.07.2025

Other

Methylphenidate-ratiopharm 40 mg hard capsules with modified release

Methyldopa (Ph.Eur.)

Initial report

08.07.2025

Production problem

Presinol 125

Methyldopa (Ph.Eur.)

Initial report

08.07.2025

Production problem

Presinol 500

Velmanase alfa

Initial report

08.07.2025

Other

Lamzede 10 mg powder for solution for infusion – OP(10×250,815mg)

Doxepine hydrochloride (Ph.Eur.)

Change notification

08.07.2025

Production problem

Doxepin 25 Holsten

Desflurane

Initial report

08.07.2025

Production problem

Suprane

Carbamazepine

Initial report

08.07.2025

Other

Carbamazepine AL 400 retard

Carbamazepine

Initial report

08.07.2025

Other

Carbamazepine AL 200 retard

Quetiapine fumarate (Ph.Eur.)

Change notification

08.07.2025

Other

Quetiapine-ratiopharm 300 mg prolonged-release tablets

Oxazepam

Change notification

08.07.2025

Other

Oxa-CT 10 mg tablets

Quetiapine fumarate (Ph.Eur.)

Change notification

08.07.2025

Other

Quetiapine AbZ 150 mg prolonged-release tablets

Calcium acetate hydrate ((with information on water content (1:x)))

Initial report

07.07.2025

Production problem

Renacet 950 mg

Midodrine hydrochloride

Initial report

07.07.2025

Other

Gutron tablets

DL-lysine acetylsalicylate – glycine (9:1)

Initial report

07.07.2025

Production problem

Acetylsalicylic acid Panpharma i.v. 500 mg

Salbutamol sulfate

Initial report

07.07.2025

Other

Bronchospray Autohaler

2025.07.14 [ フランス ]

ANSMフランス供給不足情報（2025年7月7日～7月13日）

Active ingredients	Status	Update	Specialty
clomipramine (hydrochloride)	Supply tension	11/07/2025	Anafranil 25 mg, coated tablet
clomipramine (hydrochloride)	Supply tension	11/07/2025	Clomipramine Viatris 25 mg, filmcoated tablet
tolvaptan	Supply tension	10/07/2025	Tolvaptan Biogaran 15 mg and 45 mg, tablet
alfacalcidol	Supply tension	10/07/2025	UnAlfa 1 microgram, oral capsule
disopyramide (phosphate)	Available for use	10/07/2025	Rythmodan 100 mg, capsule
cilastatin sodium, imipenem monohydrate, rebactam monohydrate	Available for use	10/07/2025	Recarbrio 500 mg/500 mg/250 mg, powder for solution for infusion
valproic acid, sodium (valproate de)	Supply tension	09/07/2025	Micropakine L.P., sustainedrelease granules in a dose sachet
bendamustine (hydrochloride) monohydrate	Supply tension	09/07/2025	Bendamustine Hikma 2.5 mg/ml, powder for solution for infusion
methylprednisolone (hydrogen-succinate)	Out of stock	09/07/2025	Methylprednisolone Viatris 40 mg, powder for solution for injection (IMIV)
Varicella-Zoster Virus (VZV) glycoprotein E antigen (recombinant, adjuvanted) ((MAMMIFERE/HAMSTER/CELLULES CHO))	Supply tension	08/07/2025	Shingrix, powder and suspension for injectable suspension. Herpes zoster vaccine (recombinant, adjuvanted)
cyamemazine	Supply tension	08/07/2025	Tercian 50 mg/5 ml, solution for injection in ampoule
raltegravir potassium	Available for use	08/07/2025	Isentress 100 mg, granules for oral suspension
insulin aspart isophane biphasic (yeast/saccharomyces cerevisiae)	Available for use	08/07/2025	NovoMix 50 Flexpen 100 Units/ml, suspension for injection in prefilled pen
etilefrine	Available for use	08/07/2025	Effortil 5 mg, tablet
risperidone	Supply tension	07/07/2025	Risperidone 0.5 mg, 1 mg, 2 mg 3 mg and 4 mg orodispersible tablet
insulin aspart (yeast/saccharomyces cerevisiae)	Supply tension	07/07/2025	Fiasp Pumpcart 100 units/ml, solution for injection in cartridge
cyclophosphamide	Available for use	07/07/2025	Endoxan 50 mg, coated tablet

2025.07.14 [ オーストラリア ]

TGAオーストラリア供給不足情報（2025年7月7日～7月13日）

Active ingredients	Dosage form	Quantity of active ingredients	Availability	Reason	Last updated
valaciclovir	Tablet, film coated	500 mg	Limited Availability	Manufacturing	11/07/2025
losartan potassium	Tablet, film coated	50 mg	Limited Availability	Manufacturing	11/07/2025
losartan potassium	Tablet, film coated	25 mg	Limited Availability	Manufacturing	11/07/2025
risperidone	Tablet, film coated	2 mg	Available	Manufacturing	11/07/2025
pioglitazone hydrochloride	Tablet	16.63 mg	Available	Manufacturing	11/07/2025
risedronate sodium hemipentahydrate	Tablet, film coated	173.4 mg	Limited Availability	Manufacturing	11/07/2025
phenobarbital	Tablet, uncoated	30 mg	Available	Manufacturing	11/07/2025
quetiapine fumarate	Tablet, modified release	57.565 mg	Available	Unexpected increase in consumer demand	11/07/2025
bosentan monohydrate	Tablet, film coated	129.082 mg	Limited Availability	Manufacturing	11/07/2025
pemetrexed disodium	Injection, powder for	110.28 mg	Unavailable	Manufacturing	11/07/2025
pemetrexed disodium	Injection, powder for	1102.8 mg	Unavailable	Manufacturing	11/07/2025
citalopram hydrobromide	Tablet, film coated	12.495 mg	Limited Availability	Manufacturing	11/07/2025
daptomycin	Injection, powder for	350 mg	Available	Manufacturing	11/07/2025
sodium lactate~icodextrin~calcium chloride dihydrate~magnesium chloride hexahydrate~sodium chloride	Solution, dialysis	4.5 g/L~75 g/L~257 mg/L~51 mg/L~5.4 g/L	Limited Availability	Manufacturing	11/07/2025
methylphenidate hydrochloride	Tablet, uncoated	10 mg	Available	Manufacturing	10/07/2025
ethinylestradiol~dienogest	Tablet, sugar coated	.03 mg~2 mg	Available	Commercial Changes / Commercial viability	10/07/2025
fludarabine phosphate	Injection, powder for	50 mg	Unavailable	Manufacturing	10/07/2025
montelukast sodium	Tablet, chewable	4.16 mg	Limited Availability	Manufacturing	10/07/2025
montelukast sodium	Tablet, film coated	10.4 mg	Available	Manufacturing	10/07/2025
clopidogrel hydrogen sulfate	Tablet, film coated	97.875 mg	Limited Availability	Unexpected increase in consumer demand	10/07/2025
tramadol hydrochloride	Tablet, modified release	200 mg	Limited Availability	Manufacturing	10/07/2025
anastrozole	Tablet, film coated	1 mg	Available	Manufacturing	10/07/2025
cefuroxime axetil	Tablet, film coated	300.715 mg	Available	Manufacturing	10/07/2025
pegaspargase	Solution, powder for	750 U/mL	Available	Manufacturing	10/07/2025
atorvastatin calcium trihydrate~ezetimibe	Tablet, film coated	41.363 mg~10 mg	Available	Manufacturing	10/07/2025
dimethyl fumarate	Capsule, enteric	120 mg	Unavailable	Manufacturing	10/07/2025
lurasidone hydrochloride	Tablet, film coated	40 mg	Unavailable	Manufacturing	10/07/2025
Albumin	Injection	.3 mg/mL	Unavailable	Manufacturing	10/07/2025
midazolam maleate	Solution	10.2 mg	Limited Availability	Manufacturing	10/07/2025
rosuvastatin calcium~ezetimibe	Tablet~Tablet, film coated	41.6 mg~10 mg	Limited Availability	Manufacturing	10/07/2025
Peginterferon alfa2a	Injection, solution	135 microgram	Limited Availability	Unexpected increase in consumer demand	10/07/2025
Peginterferon alfa2a	Injection, solution	180 microgram	Unavailable	Unexpected increase in consumer demand	10/07/2025
olanzapine pamoate monohydrate	Injection, powder for	483 mg	Limited Availability	Transport / Logistic issues / Storage capacity issues	9/07/2025
methotrexate	Tablet, uncoated	2.5 mg	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	9/07/2025
artemether~lumefantrine	Tablet, dispersible	20 mg~120 mg	Unavailable	Commercial Changes / Commercial viability	9/07/2025
riluzole	Tablet, film coated	50 mg	Limited Availability	Manufacturing	9/07/2025
ondansetron	Tablet, orally disintegrating	8 mg	Available	Manufacturing	9/07/2025
betamethasone dipropionate~calcipotriol	Foam	264 microgram/g~20.5 microgram/g	Limited Availability	Transport / Logistic issues / Storage capacity issues	9/07/2025
atorvastatin calcium trihydrate	Tablet, film coated	86.76 mg	Unavailable	Manufacturing	9/07/2025
fluorouracil	Injection, solution	50 mg/mL	Unavailable	Manufacturing	9/07/2025
paclitaxel	Injection, powder for	100 mg	Limited Availability	Manufacturing	9/07/2025
desvenlafaxine	Tablet, modified release	100 mg	Available	Manufacturing	9/07/2025
permethrin	Cream	50 mg/g	Limited Availability	Commercial Changes / Commercial viability	9/07/2025
galantamine~galantamine hydrobromide	Capsule, modified release	16 mg~20.51 mg	Available	Unexpected increase in demand due to other sponsors unable to supply	9/07/2025
zolpidem tartrate	Tablet, film coated	10 mg	Available	Unexpected increase in consumer demand	8/07/2025
morphine sulfate pentahydrate	Tablet, modified release	10 mg	Unavailable	Manufacturing	8/07/2025
morphine sulfate pentahydrate	Tablet, modified release	30 mg	Unavailable	Manufacturing	8/07/2025
morphine sulfate pentahydrate	Tablet, modified release	60 mg	Unavailable	Manufacturing	8/07/2025
morphine sulfate pentahydrate	Tablet, modified release	100 mg	Unavailable	Manufacturing	8/07/2025
amiodarone hydrochloride	Injection, solution	150 mg	Available	Unexpected increase in demand due to other sponsors unable to supply	8/07/2025
indapamide hemihydrate	Tablet, sugar coated	2.5 mg	Available	Manufacturing	8/07/2025
nicorandil	Tablet	10 mg	Unavailable	Manufacturing	8/07/2025
paclitaxel	Injection, concentrated	300 mg	Limited Availability	Manufacturing	8/07/2025
calcipotriol~betamethasone dipropionate	Ointment	52.2 microgram/g~643 microgram/g	Available	Manufacturing	8/07/2025
sodium valproate	Injection, solution	400 mg	Available	Manufacturing	8/07/2025
estradiol~estradiol~norethisterone acetate	Drug delivery system, transdermal	.78 mg~.62 mg~2.7 mg	Unavailable	Manufacturing	8/07/2025
levothyroxine sodium	Tablet	75 microgram	Unavailable	Manufacturing	8/07/2025
prazosin hydrochloride	Tablet, uncoated	5.5 mg	Unavailable	Manufacturing	8/07/2025
prucalopride succinate	Tablet, film coated	2.642 mg	Unavailable	Transport / Logistic issues / Storage capacity issues	7/07/2025
galantamine hydrobromide	Capsule, modified release	20.504 mg	Unavailable	Manufacturing	7/07/2025
galantamine hydrobromide	Capsule, modified release	30.756 mg	Unavailable	Manufacturing	7/07/2025
deoxycholic acid	Injection, solution	10 mg/mL	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	7/07/2025
ezetimibe	Tablet, uncoated	10 mg	Unavailable	Unexpected increase in consumer demand	7/07/2025
nicorandil	Tablet, uncoated	10 mg	Limited Availability	Manufacturing	7/07/2025
nitisinone	Tablet	10 mg	Unavailable	Manufacturing	7/07/2025
nitisinone	Tablet	5 mg	Limited Availability	Manufacturing	7/07/2025
avatrombopag maleate	Tablet, film coated	23.6 mg	Available	Manufacturing	7/07/2025

2025.07.14 [ 米国 ]

ASHP供給不足情報（2025年7月7日～7月13日）

Generic Name	Shortage Status	Revision Date
Penicillin G Benzathine	Current Shortages	13-Jul-25
Amoxicillin Oral Presentations	Current Shortages	11-Jul-25
Budesonide Suspension for Inhalation	Current Shortages	11-Jul-25
Doxazosin Extended Release Oral Tablets	Current Shortages	11-Jul-25
Heparin Injection	Current Shortages	11-Jul-25
Cefotaxime Sodium Injection	Current Shortages	10-Jul-25
Desmopressin Acetate Nasal Spray	Current Shortages	10-Jul-25
50% Dextrose Injection	Current Shortages	9-Jul-25
Docetaxel Injection	Current Shortages	9-Jul-25
Droperidol Injection	Resolved Shortages	9-Jul-25
Epinephrine Injection	Current Shortages	9-Jul-25
Hydroxyethyl Starch (Hetastarch)	Current Shortages	9-Jul-25
Methylprednisolone Sodium Succinate Injection	Current Shortages	9-Jul-25
Nalbuphine Injection	Current Shortages	9-Jul-25
Phenylephrine Ophthalmic Solution	Current Shortages	9-Jul-25
Quinapril Tablets	Current Shortages	9-Jul-25
Rocuronium Injection	Current Shortages	9-Jul-25
Terbutaline Sulfate Injection	Current Shortages	9-Jul-25
Triamcinolone Hexacetonide Injection	Current Shortages	9-Jul-25
Amphotericin B Lipid Complex	Current Shortages	8-Jul-25
Imatinib Mesylate Tablets	Current Shortages	8-Jul-25
Oxycodone Hydrochloride Immediate-Release Tablets	Current Shortages	7-Jul-25

2025.07.14 [ 米国 ]
FDA供給不足情報：新規・更新（2025年7月7日～7月13日）
New
July 10, 2025
- Levothyroxine Sodium Tablet (Discontinuation)
July 8, 2025
- Morphine Sulfate Injection (Discontinuation)
- Oseltamivir Phosphate Capsule (Discontinuation)
- Potassium Chloride Tablet, Extended Release (Discontinuation)
Updated
July 10, 2025
- Bupivacaine Hydrochloride Injection (Currently In Shortage)
- Bupivacaine Hydrochloride, Epinephrine Bitartrate Injection (Currently In Shortage)
- Dobutamine Hydrochloride Injection (Currently In Shortage)
- Epinephrine Bitartrate, Lidocaine Hydrochloride Injection (Currently In Shortage)
- Fentanyl Citrate Injection (Currently In Shortage)
- Hydrocortisone Sodium Succinate Injection (Currently In Shortage)
- Hydromorphone Hydrochloride Injection (Currently In Shortage)
- Lidocaine Hydrochloride Injection (Currently In Shortage)
- Lisdexamfetamine Dimesylate Capsule (Currently In Shortage)
- Meperidine Hydrochloride Injection (Currently In Shortage)
- Methotrexate Sodium Injection (Currently In Shortage)
- Methylprednisolone Acetate Injection (Currently In Shortage)
- Morphine Sulfate Injection (Currently In Shortage)
- Penicillin G Benzathine Injection (Currently In Shortage)
- Rocuronium Bromide Injection (Currently In Shortage)
- Sodium Bicarbonate Injection (Currently In Shortage)
- Sufentanil Citrate Injection (Currently In Shortage)
July 9, 2025
- Amphetamine Aspartate Monohydrate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate Tablet (Currently In Shortage)
July 8, 2025
- Amphetamine Aspartate Monohydrate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate Tablet (Currently In Shortage)
- Azacitidine Injection (Currently In Shortage)
- Carboplatin Injection (Currently In Shortage)
- Dexmedetomidine Hydrochloride Injection (Currently In Shortage)
- Hydromorphone Hydrochloride Injection (Currently In Shortage)
- Leucovorin Calcium Injection (Resolved)
- Lisdexamfetamine Dimesylate Capsule (Currently In Shortage)
- Mefloquine Hydrochloride Tablet (Currently In Shortage)
- Methotrexate Sodium Injection (Currently In Shortage)
- Methylphenidate Hydrochloride Tablet, Extended Release (Currently In Shortage)
- Streptozocin Powder, For Solution (Currently In Shortage)
July 7, 2025
- Carboplatin Injection (Currently In Shortage)
- Lisdexamfetamine Dimesylate Capsule (Currently In Shortage)
- Lisdexamfetamine Dimesylate Tablet, Chewable (Currently In Shortage)
- Methylphenidate Hydrochloride Tablet, Extended Release (Currently In Shortage)
- Naltrexone Hydrochloride Tablet (Currently In Shortage)
- Peritoneal Dialysis Solution (Resolved)
- Rocuronium Bromide Injection (Currently In Shortage)
- Technetium TC-99M Pyrophosphate Kit Injection (Currently In Shortage)