海外医薬品不足情報｜医薬政策企画 P-Cubed

諸外国不足状況
【毎日更新】

• 2025.01.18 [ 英国 ]
  NICE医薬品情報サービス（2024年10月14日から2024年10月18日）

  医薬品供給のお知らせ:塩酸アポモルヒネ(APO-go® PFS)50mg / 10ml輸液プレフィルドシリンジ用溶液 APO-go®(塩酸アポモルヒネ)PFSは製造中止です。2025年4月上旬以降、供給が尽きることが予想されます。輸液カートリッジ用のAPO-GO® POD(塩酸アポモルヒネ半水和物)100mg / 20ml溶液は引き続き利用可能であり、需要の増加に対応できます。 出典:Community Pharmacy England

   

  医薬品供給通知:NovoRapid®(インスリンアスパルト)FlexTouch® 100ユニット/ ml注射用溶液3mlプレフィルドペン-更新 2024 年 10 月の通知に更新します。NovoRapid(インスリンアスパルト)FlexTouch® 100ユニット/ml注射用溶液3mlプレフィルドペンは、2025年2月下旬まで在庫切れとなり、その後2025年3月から販売終了となります。 SPSの解説を読む 出典:Community Pharmacy England

• 2025.01.15 [ 英国 ]
  英国Specialist Pharmacy Service医薬品不足への支援　2025年1月9日

  Prescribing and ordering available pancreatic enzyme replacement therapies (Last updated 9 January 2025)

  Update: Each Integrated Care Board (ICB) should have a local management plan to ensure patients are not left without pancreatic enzyme replacement therapies（PERT）. This may include a centralised route to obtain unlicensed imports. Refer to your local ICB to find out if a centralised route is available.

• 2025.01.13 [ フランス ]
  ANSMフランス供給不足情報（2025年1月6日～2025年1月12日）

  Ingredients	Status	Update	Specialty
  cilastatin sodium, imipenem monohydrate, rebactam monohydrate	Supply tension	10-Jan-25	Recarbrio 500 mg/500 mg/250 mg, powder for solution for infusion –
  acetazolamide	Supply tension	10-Jan-25	Diamox 250 mg, scored tablet –
  paclitaxel	Supply tension	Jan. 10, 2025	Paclitaxel AHCL 6 mg/ml, dilutable solution for infusion – 100 ml bottle –
  dexrazoxane hydrochloride	Out of stock	10-Jan-25	Savene 20 mg/ml, powder and solvent for solution to be diluted for infusion –
  lenalidomide	Supply voltage	Jan. 10, 2025	Lenalidomide Mylan, capsule –
  nab paclitaxel	Supply tension	Jan. 9, 2025	Pazenir 5 mg/mL, powder for dispersal by infusion –
  cyanocobalamin	Supply tension	Jan. 9, 2025	Vitamin B12 Delagrange 1000 micrograms/2 ml, solution for injection (IM) and oral use –
  sodium fluorescein	Availability	Jan. 8, 2025	Fluorescein Faure 0.5%, eye drops solution in single-dose container –
  peginterferon alfa-2a	Supply tension	Jan. 7, 2025	Pegasys 90 micrograms, 135 micrograms and 180 micrograms solution for injection in pre-filled syringes –
  latanoprost	Availability	Jan. 7, 2025	Monoprost 50 micrograms/ml, eye drops solution in single-dose container –

• 2025.01.13 [ ドイツ ]
  BfArMボトルネック・レポート（2025年1月6日～2025年1月12日）

  Active ingredients	Type of reason	Message type	Date of the last message
  Ezetimibe; Simvastatin	Production problem	Change notification	10.01.2025
  Hydromorphone hydrochloride	Other	Change notification	10.01.2025
  Trazodone hydrochloride	Other	Change notification	10.01.2025
  Linezolid	Production problem	Change notification	10.01.2025
  Galantamine hydrobromide	Production problem	Change notification	10.01.2025
  Atomoxetine hydrochloride	Production problem	Change notification	10.01.2025
  Quetiapine fumarate (Ph.Eur.)	Production problem	Change notification	10.01.2025
  Rizatriptan benzoate	Production problem	Change notification	10.01.2025
  Fluticasone propionate (Ph.Eur.)	Other	Change notification	09.01.2025
  Etoposide	Other	Change notification	09.01.2025
  Melperone hydrochloride	Other	Change notification	09.01.2025
  Methylphenidate hydrochloride	Production problem	Change notification	09.01.2025
  Buspirone hydrochloride	Other	Change notification	09.01.2025
  Phenoxymethylpenicillin potassium	Other	Change notification	09.01.2025
  Trihexyphenidyl hydrochloride	Production problem	Change notification	09.01.2025
  Doxycycline monohydrate	Other	Change notification	09.01.2025
  Calcium folinate	Other	Change notification	09.01.2025
  Ciprofloxacin hydrochloride (1:1) 1 H<2>O	Other	Change notification	09.01.2025
  Oxycodone hydrochloride (Ph.Eur.)	Other	Change notification	08.01.2025
  Hydromorphone hydrochloride	Other	Change notification	08.01.2025
  Buprenorphine	Other	Change notification	08.01.2025
  Salbutamol sulfate	Other	Change notification	07.01.2025
  Methylphenidate hydrochloride	Other	Change notification	07.01.2025
  Quetiapine fumarate (Ph.Eur.)	Other	Change notification	07.01.2025
  Progesterone	Production problem	Change notification	06.01.2025

• 2025.01.13 [ オーストラリア ]
  TGAオーストラリア供給不足情報（2025年1月6日～2025年1月12日）

  Active ingredients	Dosage form	Quantity of active ingredients	Shortage status	Availability	Reason	Last updated
  cytarabine	Injection, solution	100 mg	Resolved	Available	Unexpected increase in consumer demand	10/01/2025
  topiramate	Tablet, film coated	100 mg	Resolved	Available	Manufacturing	10/01/2025
  topiramate	Tablet, film coated	200 mg	Resolved	Available	Manufacturing	10/01/2025
  levetiracetam	Tablet, film coated	500 mg	Resolved	Available	Manufacturing	10/01/2025
  clonidine hydrochloride	Tablet, uncoated	100 microgram	Current	Unavailable	Transport / Logistic issues / Storage capacity issues	10/01/2025
  bisoprolol fumarate	Tablet	2.5 mg	Resolved	Available	Manufacturing	10/01/2025
  azithromycin dihydrate	Tablet, film coated	524.05 mg	Current	Unavailable	Manufacturing	10/01/2025
  eftrenonacog alfa	Injection, powder for	1000 IU	Resolved	Available	Unexpected increase in consumer demand	10/01/2025
  eftrenonacog alfa	Injection, powder for	250 IU	Current	Unavailable	Unexpected increase in consumer demand	10/01/2025
  clopidogrel besilate	Tablet, film coated	112.1 mg	Current	Limited Availability	Manufacturing	10/01/2025
  clonidine hydrochloride	Tablet	100 microgram	Current	Unavailable	Unexpected increase in consumer demand	10/01/2025
  clonidine hydrochloride	Tablet	100 microgram	Current	Unavailable	Manufacturing	10/01/2025
  irbesartan	Tablet, film coated	300 mg	Resolved	Available	Manufacturing	10/01/2025
  ivabradine hydrochloride	Tablet, film coated	8.085 mg	Anticipated	Available	Manufacturing	10/01/2025
  mesalazine	Tablet, enteric coated	250 mg	Current	Limited Availability	Manufacturing	10/01/2025
  risperidone	Tablet, film coated	.5 mg	Resolved	Available	Manufacturing	10/01/2025
  ravulizumab	Injection, intravenous infusion	100 mg/mL	Resolved	Available	Transport / Logistic issues / Storage capacity issues	10/01/2025
  prucalopride succinate	Tablet	2.642 mg	Current	Unavailable	Manufacturing	10/01/2025
  thiotepa	Injection, powder for	15 mg	Resolved	Available	Unexpected increase in consumer demand	10/01/2025
  thiotepa	Injection, powder for	15 mg	Current	Unavailable	Commercial Changes / Commercial viability	10/01/2025
  estradiol hemihydrate	Drug delivery system, transdermal	1.54 mg	Current	Limited Availability	Unexpected increase in demand due to other sponsors unable to supply	10/01/2025
  doxycycline hyclate	Tablet, film coated	57.5 mg	Current	Limited Availability	Manufacturing	10/01/2025
  estradiol hemihydrate	Drug delivery system, transdermal	.77 mg	Current	Limited Availability	Unexpected increase in demand due to other sponsors unable to supply	10/01/2025
  estradiol hemihydrate	Drug delivery system, transdermal	3.09 mg	Current	Limited Availability	Unexpected increase in demand due to other sponsors unable to supply	10/01/2025
  metformin hydrochloride	Tablet, film coated	500 mg	Current	Unavailable	Manufacturing	10/01/2025
  estradiol hemihydrate	Drug delivery system, transdermal	2.32 mg	Current	Limited Availability	Unexpected increase in demand due to other sponsors unable to supply	10/01/2025
  clonidine hydrochloride	Tablet, uncoated	150 microgram	Current	Unavailable	Transport / Logistic issues / Storage capacity issues	10/01/2025
  famotidine	Tablet, film coated	20 mg	Current	Unavailable	Manufacturing	10/01/2025
  famotidine	Tablet, film coated	40 mg	Current	Unavailable	Manufacturing	10/01/2025
  nizatidine	Capsule, hard	300 mg	Current	Limited Availability	Manufacturing	10/01/2025
  dopamine hydrochloride	Injection, concentrated	40 mg/mL	Resolved	Available	Manufacturing	9/01/2025
  paroxetine hydrochloride	Tablet, film coated	22.21 mg	Current	Limited Availability	Manufacturing	9/01/2025
  mesalazine	Tablet, enteric coated	800 mg	Current	Limited Availability	Manufacturing	9/01/2025
  Trastuzumab	Injection, powder for	60 mg	Current	Unavailable	Manufacturing	9/01/2025
  naloxone hydrochloride dihydrate	Spray, nasal	2.2 mg/actuation	Current	Limited Availability	Manufacturing	9/01/2025
  daptomycin	Injection, powder for	500 mg	Resolved	Available	Manufacturing	9/01/2025
  Adalimumab	Injection, solution	40 mg	Discontinued	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	9/01/2025
  carbamazepine	Tablet, modified release	200 mg	Resolved	Available	Manufacturing	9/01/2025
  oxcarbazepine	Tablet, film coated	150 mg	Resolved	Available	Manufacturing	9/01/2025
  citalopram hydrobromide	Tablet, film coated	24.98 mg	Current	Limited Availability	Manufacturing	9/01/2025
  Meningococcal polysaccharide group C~Tetanus toxoid	Injection, suspension	20 microgram/mL~20 microgram/mL	Discontinued	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	9/01/2025
  diclofenac sodium	Suppository, moulded	50 mg	Resolved	Available	Transport / Logistic issues / Storage capacity issues	9/01/2025
  sevelamer hydrochloride	Tablet, film coated	800 mg	Resolved	Available	Manufacturing	8/01/2025
  hydrocortisone acetate	Eye Ointment	10 mg/g	Current	Unavailable	Manufacturing	8/01/2025
  tamsulosin hydrochloride~dutasteride	Capsule, modified release	400 microgram~500 microgram	Resolved	Available	Manufacturing	8/01/2025
  rosuvastatin calcium~ezetimibe	Tablet~Tablet, film coated	20.791 mg~10 mg	Resolved	Available	Manufacturing	8/01/2025
  quetiapine fumarate	Tablet, film coated	28.78 mg	Current	Limited Availability	Manufacturing	8/01/2025
  efmoroctocog alfa	Injection, powder for	2000 IU	Current	Unavailable	Unexpected increase in consumer demand	8/01/2025
  cisatracurium besilate	Injection, solution	14.07 mg	Current	Unavailable	Transport / Logistic issues / Storage capacity issues	8/01/2025
  citalopram hydrobromide	Tablet, film coated	12.495 mg	Current	Unavailable	Manufacturing	8/01/2025
  buprenorphine	Drug delivery system, transdermal	5 mg	Current	Limited Availability	Manufacturing	8/01/2025
  isotretinoin	Capsule, soft	10 mg	Current	Unavailable	Manufacturing	8/01/2025
  olmesartan medoxomil~hydrochlorothiazide	Tablet	20 mg~12.5 mg	Current	Unavailable	Manufacturing	8/01/2025
  hydrochlorothiazide~olmesartan medoxomil	Tablet	25 mg~40 mg	Current	Limited Availability	Manufacturing	8/01/2025
  Trastuzumab	Injection, powder for	150 mg	Current	Unavailable	Manufacturing	8/01/2025
  clobazam	Tablet, uncoated	10 mg	Current	Unavailable	Manufacturing	8/01/2025
  oxaliplatin	Injection, concentrated	100 mg	Current	Limited Availability	Manufacturing	8/01/2025
  reboxetine mesilate	Tablet, uncoated	5.224 mg	Anticipated	Available	Manufacturing	8/01/2025
  ethosuximide	Capsule, soft	250 mg	Discontinued	Unavailable	Manufacturing	8/01/2025
  acetylcysteine	Injection, concentrated	2 g	Current	Unavailable	Manufacturing	7/01/2025
  fentanyl	Drug delivery system, transdermal	2.1 mg	Resolved	Available	Unexpected increase in demand due to other sponsors unable to supply	7/01/2025
  tramadol hydrochloride	Tablet, modified release	200 mg	Current	Limited Availability	Manufacturing	7/01/2025
  bisoprolol fumarate	Tablet	5 mg	Resolved	Available	Manufacturing	7/01/2025
  duloxetine hydrochloride	Capsule, enteric	33.65 mg	Current	Limited Availability	Manufacturing	7/01/2025
  bortezomib	Injection, powder for	3.5 mg	Current	Limited Availability	Manufacturing	7/01/2025
  amlodipine besilate	Tablet	6.93 mg	Current	Limited Availability	Manufacturing	7/01/2025
  doxylamine succinate~codeine phosphate hemihydrate~paracetamol	Tablet, uncoated	5.1 mg~10 mg~500 mg	Resolved	Available	Manufacturing	7/01/2025
  cefuroxime axetil	Tablet, film coated	300.715 mg	Current	Limited Availability	Manufacturing	7/01/2025
  ezetimibe	Tablet	10 mg	Resolved	Available	Unexpected increase in consumer demand	7/01/2025
  tadalafil	Tablet, film coated	5 mg	Resolved	Available	Manufacturing	7/01/2025
  tadalafil	Tablet, film coated	20 mg	Resolved	Available	Manufacturing	7/01/2025
  amlodipine besilate~olmesartan medoxomil	Tablet, film coated	6.935 mg~40 mg	Current	Unavailable	Manufacturing	7/01/2025
  dexmedetomidine hydrochloride	Injection, concentrated	118 microgram/mL	Resolved	Available	Manufacturing	7/01/2025
  dimethyl fumarate	Capsule, enteric	120 mg	Current	Limited Availability	Manufacturing	7/01/2025
  metoprolol succinate	Tablet, modified release	23.75 mg	Current	Limited Availability	Manufacturing	7/01/2025
  lanreotide acetate	Injection, solution	133.33 mg	Resolved	Available	Transport / Logistic issues / Storage capacity issues	7/01/2025
  lanreotide acetate	Injection, solution	100 mg	Resolved	Available	Transport / Logistic issues / Storage capacity issues	7/01/2025
  sitagliptin hydrochloride monohydrate	Tablet, film coated	109 mg	Current	Unavailable	Manufacturing	7/01/2025
  sitagliptin hydrochloride monohydrate	Tablet, film coated	54.5 mg	Current	Unavailable	Manufacturing	7/01/2025
  sitagliptin hydrochloride monohydrate	Tablet, film coated	27.25 mg	Current	Unavailable	Manufacturing	7/01/2025
  paracetamol	Tablet, modified release	665 mg	Current	Limited Availability	Transport / Logistic issues / Storage capacity issues	7/01/2025
  heparin sodium	Injection, solution	5000 IU/mL	Resolved	Available	Manufacturing	7/01/2025
  methylphenidate hydrochloride	Capsule, modified release	30 mg	Resolved	Available	Manufacturing	7/01/2025
  gabapentin	Tablet, film coated	800 mg	Current	Unavailable	Manufacturing	6/01/2025
  quetiapine fumarate	Tablet, film coated	28.78 mg	Resolved	Available	Manufacturing	6/01/2025
  quetiapine fumarate	Tablet, film coated	345.36 mg	Resolved	Available	Manufacturing	6/01/2025
  adefovir dipivoxil	Tablet	10 mg	Resolved	Available	Unexpected increase in consumer demand	6/01/2025
  ezetimibe	Tablet, uncoated	10 mg	Resolved	Available	Unexpected increase in demand due to other sponsors unable to supply	6/01/2025
  apomorphine hydrochloride hemihydrate	Injection, solution	10 mg	Resolved	Available	Manufacturing	6/01/2025
  lurasidone hydrochloride	Tablet, film coated	80 mg	Current	Unavailable	Manufacturing	6/01/2025
  furosemide	Injection, solution	10 mg/mL	Current	Limited Availability	Transport / Logistic issues / Storage capacity issues	6/01/2025
  rosuvastatin calcium~ezetimibe	Tablet	10.4 mg~10 mg	Current	Unavailable	Manufacturing	6/01/2025
  ezetimibe~rosuvastatin calcium	Tablet~Tablet, film coated	10 mg~41.6 mg	Current	Unavailable	Manufacturing	6/01/2025
  tamoxifen citrate	Tablet, uncoated	30.4 mg	Discontinued	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	6/01/2025
  cabergoline	Tablet, uncoated	1 mg	Anticipated	Available	Manufacturing	6/01/2025