

Active ingredients |
| Date of last message | Type of reason | AM designation | |
Methyl (5-amino-4-oxopentanoate) hydrochloride | Initial report | 11.07.2025 | Other | Metvix 160 mg/g cream | |
Semaglutide | Initial report | 11.07.2025 | Other | Ozempic 1 mg injection solution in a pre-filled pen – OP(3x3ml) | |
Salbutamol sulfate | Change notification | 11.07.2025 | Other | Sultanol inhalation solution | |
Salbutamol sulfate | Change notification | 11.07.2025 | Other | Sultanol metered aerosol | |
Flunisolid hemihydrate | Change notification | 11.07.2025 | Other | Syntaris | |
Framycetin sulfate (Ph.Eur.) | Change notification | 11.07.2025 | Other | Leukase N ointment | |
Human insulin (with manufacturing details); Isophane insulin suspension for injection (Ph.Eur.) | Initial report | 11.07.2025 | Other | Actraphane 30 FlexPen 100 IU/ml injection suspension in injector – OP(10x3ml) | |
Insulin aspart | Initial report | 11.07.2025 | Other | NovoMix 30 FlexPen 100 IU/ml injection suspension in pre-filled syringe – OP(10x3ml) | |
Promethazine hydrochloride | Initial report | 11.07.2025 | Production problem | Atosil injection solution N | |
Paliperidone palmitate | Initial report | 11.07.2025 | Other | XEPLION 50 mg depot injection suspension – OP1ml | |
Paliperidone palmitate | Initial report | 11.07.2025 | Other | XEPLION 25 mg depot injection suspension – OP1ml | |
Ampicillin sodium | Initial report | 10.07.2025 | Production problem | Ampicillin Eberth 1 g powder for solution for injection/infusion | |
Trometamol | Initial report | 10.07.2025 | Other | Tham-Köhler | |
Trometamol | Initial report | 10.07.2025 | Other | THAM-Köhler 3 M | |
Atorvastatin calcium trihydrate (Ph.Eur.) | Change notification | 10.07.2025 | Other | Atorvastatin Aristo 60 mg film-coated tablets | |
Cinacalcet hydrochloride | Initial report | 10.07.2025 | Other | Cinacalcet Mylan 60 mg film-coated tablets – OP(28×1) | |
Pramipexole dihydrochloride monohydrate | Change notification | 10.07.2025 | Other | Pramipexole Mylan 0.52 mg prolonged-release tablets | |
Pramipexole dihydrochloride monohydrate | Change notification | 10.07.2025 | Other | Pramipexole Mylan 0.26 mg prolonged-release tablets | |
Trandolapril; verapamil hydrochloride | Change notification | 10.07.2025 | Production problem | Tarka 240 mg/2 mg modified-release tablets | |
Sufentanil citrate | Initial report | 10.07.2025 | Production problem | Sufenta 50 micrograms/ml solution for injection | |
Deferasirox | Change notification | 10.07.2025 | Other | Deferasirox Mylan 180 mg film-coated tablets | |
Potassium canrenoate | Change notification | 10.07.2025 | Production problem | Aldactone 10 ml Canrenoate | |
Oxazepam | Change notification | 10.07.2025 | Other | Oxazepam AL 10 | |
Amoxicillin trihydrate | Change notification | 10.07.2025 | Other | Amoxicillin AL TS | |
Isophane insulin suspension for injection (Ph.Eur.) | Change notification | 09.07.2025 | Other | Protaphane FlexPen 100 IU/ml injection suspension in injector – OP (10x3ml) | |
Estriol | Initial report | 09.07.2025 | Other | Ovestin 1 mg cream | |
Propofol | Initial report | 09.07.2025 | Other | DISOPRIVAN 1% | |
Lidocaine hydrochloride monohydrate | Initial report | 09.07.2025 | Other | Xylocaine Gel 2% | |
Azathioprine | Initial report | 09.07.2025 | Other | Imurek 25 mg film-coated tablets | |
Levothyroxine sodium (Ph.Eur.) | Initial report | 09.07.2025 | Other | Thevier 100 | |
Levothyroxine sodium (Ph.Eur.) | Initial report | 09.07.2025 | Other | Thevier 50 | |
Methylphenidate hydrochloride | Initial report | 09.07.2025 | Other | Methylphenidate-ratiopharm 20 mg modified-release hard capsules | |
Methylphenidate hydrochloride | Initial report | 09.07.2025 | Other | Methylphenidate-ratiopharm 40 mg hard capsules with modified release | |
Methyldopa (Ph.Eur.) | Initial report | 08.07.2025 | Production problem | Presinol 125 | |
Methyldopa (Ph.Eur.) | Initial report | 08.07.2025 | Production problem | Presinol 500 | |
Velmanase alfa | Initial report | 08.07.2025 | Other | Lamzede 10 mg powder for solution for infusion – OP(10×250,815mg) | |
Doxepine hydrochloride (Ph.Eur.) | Change notification | 08.07.2025 | Production problem | Doxepin 25 Holsten | |
Desflurane | Initial report | 08.07.2025 | Production problem | Suprane | |
Carbamazepine | Initial report | 08.07.2025 | Other | Carbamazepine AL 400 retard | |
Carbamazepine | Initial report | 08.07.2025 | Other | Carbamazepine AL 200 retard | |
Quetiapine fumarate (Ph.Eur.) | Change notification | 08.07.2025 | Other | Quetiapine-ratiopharm 300 mg prolonged-release tablets | |
Oxazepam | Change notification | 08.07.2025 | Other | Oxa-CT 10 mg tablets | |
Quetiapine fumarate (Ph.Eur.) | Change notification | 08.07.2025 | Other | Quetiapine AbZ 150 mg prolonged-release tablets | |
Calcium acetate hydrate ((with information on water content (1:x))) | Initial report | 07.07.2025 | Production problem | Renacet 950 mg | |
Midodrine hydrochloride | Initial report | 07.07.2025 | Other | Gutron tablets | |
DL-lysine acetylsalicylate – glycine (9:1) | Initial report | 07.07.2025 | Production problem | Acetylsalicylic acid Panpharma i.v. 500 mg | |
Salbutamol sulfate | Initial report | 07.07.2025 | Other | Bronchospray Autohaler |
Active ingredients | Status | Update | Specialty |
clomipramine (hydrochloride) | Supply tension | 11/07/2025 | Anafranil 25 mg, coated tablet |
clomipramine (hydrochloride) | Supply tension | 11/07/2025 | Clomipramine Viatris 25 mg, filmcoated tablet |
tolvaptan | Supply tension | 10/07/2025 | Tolvaptan Biogaran 15 mg and 45 mg, tablet |
alfacalcidol | Supply tension | 10/07/2025 | UnAlfa 1 microgram, oral capsule |
disopyramide (phosphate) | Available for use | 10/07/2025 | Rythmodan 100 mg, capsule |
cilastatin sodium, imipenem monohydrate, rebactam monohydrate | Available for use | 10/07/2025 | Recarbrio 500 mg/500 mg/250 mg, powder for solution for infusion |
valproic acid, sodium (valproate de) | Supply tension | 09/07/2025 | Micropakine L.P., sustainedrelease granules in a dose sachet |
bendamustine (hydrochloride) monohydrate | Supply tension | 09/07/2025 | Bendamustine Hikma 2.5 mg/ml, powder for solution for infusion |
methylprednisolone (hydrogen-succinate) | Out of stock | 09/07/2025 | Methylprednisolone Viatris 40 mg, powder for solution for injection (IMIV) |
Varicella-Zoster Virus (VZV) glycoprotein E antigen (recombinant, adjuvanted) ((MAMMIFERE/HAMSTER/CELLULES CHO)) | Supply tension | 08/07/2025 | Shingrix, powder and suspension for injectable suspension. Herpes zoster vaccine (recombinant, adjuvanted) |
cyamemazine | Supply tension | 08/07/2025 | Tercian 50 mg/5 ml, solution for injection in ampoule |
raltegravir potassium | Available for use | 08/07/2025 | Isentress 100 mg, granules for oral suspension |
insulin aspart isophane biphasic (yeast/saccharomyces cerevisiae) | Available for use | 08/07/2025 | NovoMix 50 Flexpen 100 Units/ml, suspension for injection in prefilled pen |
etilefrine | Available for use | 08/07/2025 | Effortil 5 mg, tablet |
risperidone | Supply tension | 07/07/2025 | Risperidone 0.5 mg, 1 mg, 2 mg 3 mg and 4 mg orodispersible tablet |
insulin aspart (yeast/saccharomyces cerevisiae) | Supply tension | 07/07/2025 | Fiasp Pumpcart 100 units/ml, solution for injection in cartridge |
cyclophosphamide | Available for use | 07/07/2025 | Endoxan 50 mg, coated tablet |
Active ingredients | Dosage form | Quantity of active ingredients | Availability | Reason | Last updated |
valaciclovir | Tablet, film coated | 500 mg | Limited Availability | Manufacturing | 11/07/2025 |
losartan potassium | Tablet, film coated | 50 mg | Limited Availability | Manufacturing | 11/07/2025 |
losartan potassium | Tablet, film coated | 25 mg | Limited Availability | Manufacturing | 11/07/2025 |
risperidone | Tablet, film coated | 2 mg | Available | Manufacturing | 11/07/2025 |
pioglitazone hydrochloride | Tablet | 16.63 mg | Available | Manufacturing | 11/07/2025 |
risedronate sodium hemipentahydrate | Tablet, film coated | 173.4 mg | Limited Availability | Manufacturing | 11/07/2025 |
phenobarbital | Tablet, uncoated | 30 mg | Available | Manufacturing | 11/07/2025 |
quetiapine fumarate | Tablet, modified release | 57.565 mg | Available | Unexpected increase in consumer demand | 11/07/2025 |
bosentan monohydrate | Tablet, film coated | 129.082 mg | Limited Availability | Manufacturing | 11/07/2025 |
pemetrexed disodium | Injection, powder for | 110.28 mg | Unavailable | Manufacturing | 11/07/2025 |
pemetrexed disodium | Injection, powder for | 1102.8 mg | Unavailable | Manufacturing | 11/07/2025 |
citalopram hydrobromide | Tablet, film coated | 12.495 mg | Limited Availability | Manufacturing | 11/07/2025 |
daptomycin | Injection, powder for | 350 mg | Available | Manufacturing | 11/07/2025 |
sodium lactate~icodextrin~calcium chloride dihydrate~magnesium chloride hexahydrate~sodium chloride | Solution, dialysis | 4.5 g/L~75 g/L~257 mg/L~51 mg/L~5.4 g/L | Limited Availability | Manufacturing | 11/07/2025 |
methylphenidate hydrochloride | Tablet, uncoated | 10 mg | Available | Manufacturing | 10/07/2025 |
ethinylestradiol~dienogest | Tablet, sugar coated | .03 mg~2 mg | Available | Commercial Changes / Commercial viability | 10/07/2025 |
fludarabine phosphate | Injection, powder for | 50 mg | Unavailable | Manufacturing | 10/07/2025 |
montelukast sodium | Tablet, chewable | 4.16 mg | Limited Availability | Manufacturing | 10/07/2025 |
montelukast sodium | Tablet, film coated | 10.4 mg | Available | Manufacturing | 10/07/2025 |
clopidogrel hydrogen sulfate | Tablet, film coated | 97.875 mg | Limited Availability | Unexpected increase in consumer demand | 10/07/2025 |
tramadol hydrochloride | Tablet, modified release | 200 mg | Limited Availability | Manufacturing | 10/07/2025 |
anastrozole | Tablet, film coated | 1 mg | Available | Manufacturing | 10/07/2025 |
cefuroxime axetil | Tablet, film coated | 300.715 mg | Available | Manufacturing | 10/07/2025 |
pegaspargase | Solution, powder for | 750 U/mL | Available | Manufacturing | 10/07/2025 |
atorvastatin calcium trihydrate~ezetimibe | Tablet, film coated | 41.363 mg~10 mg | Available | Manufacturing | 10/07/2025 |
dimethyl fumarate | Capsule, enteric | 120 mg | Unavailable | Manufacturing | 10/07/2025 |
lurasidone hydrochloride | Tablet, film coated | 40 mg | Unavailable | Manufacturing | 10/07/2025 |
Albumin | Injection | .3 mg/mL | Unavailable | Manufacturing | 10/07/2025 |
midazolam maleate | Solution | 10.2 mg | Limited Availability | Manufacturing | 10/07/2025 |
rosuvastatin calcium~ezetimibe | Tablet~Tablet, film coated | 41.6 mg~10 mg | Limited Availability | Manufacturing | 10/07/2025 |
Peginterferon alfa2a | Injection, solution | 135 microgram | Limited Availability | Unexpected increase in consumer demand | 10/07/2025 |
Peginterferon alfa2a | Injection, solution | 180 microgram | Unavailable | Unexpected increase in consumer demand | 10/07/2025 |
olanzapine pamoate monohydrate | Injection, powder for | 483 mg | Limited Availability | Transport / Logistic issues / Storage capacity issues | 9/07/2025 |
methotrexate | Tablet, uncoated | 2.5 mg | Reduction in supply until supply is exhausted | Commercial Changes / Commercial viability | 9/07/2025 |
artemether~lumefantrine | Tablet, dispersible | 20 mg~120 mg | Unavailable | Commercial Changes / Commercial viability | 9/07/2025 |
riluzole | Tablet, film coated | 50 mg | Limited Availability | Manufacturing | 9/07/2025 |
ondansetron | Tablet, orally disintegrating | 8 mg | Available | Manufacturing | 9/07/2025 |
betamethasone dipropionate~calcipotriol | Foam | 264 microgram/g~20.5 microgram/g | Limited Availability | Transport / Logistic issues / Storage capacity issues | 9/07/2025 |
atorvastatin calcium trihydrate | Tablet, film coated | 86.76 mg | Unavailable | Manufacturing | 9/07/2025 |
fluorouracil | Injection, solution | 50 mg/mL | Unavailable | Manufacturing | 9/07/2025 |
paclitaxel | Injection, powder for | 100 mg | Limited Availability | Manufacturing | 9/07/2025 |
desvenlafaxine | Tablet, modified release | 100 mg | Available | Manufacturing | 9/07/2025 |
permethrin | Cream | 50 mg/g | Limited Availability | Commercial Changes / Commercial viability | 9/07/2025 |
galantamine~galantamine hydrobromide | Capsule, modified release | 16 mg~20.51 mg | Available | Unexpected increase in demand due to other sponsors unable to supply | 9/07/2025 |
zolpidem tartrate | Tablet, film coated | 10 mg | Available | Unexpected increase in consumer demand | 8/07/2025 |
morphine sulfate pentahydrate | Tablet, modified release | 10 mg | Unavailable | Manufacturing | 8/07/2025 |
morphine sulfate pentahydrate | Tablet, modified release | 30 mg | Unavailable | Manufacturing | 8/07/2025 |
morphine sulfate pentahydrate | Tablet, modified release | 60 mg | Unavailable | Manufacturing | 8/07/2025 |
morphine sulfate pentahydrate | Tablet, modified release | 100 mg | Unavailable | Manufacturing | 8/07/2025 |
amiodarone hydrochloride | Injection, solution | 150 mg | Available | Unexpected increase in demand due to other sponsors unable to supply | 8/07/2025 |
indapamide hemihydrate | Tablet, sugar coated | 2.5 mg | Available | Manufacturing | 8/07/2025 |
nicorandil | Tablet | 10 mg | Unavailable | Manufacturing | 8/07/2025 |
paclitaxel | Injection, concentrated | 300 mg | Limited Availability | Manufacturing | 8/07/2025 |
calcipotriol~betamethasone dipropionate | Ointment | 52.2 microgram/g~643 microgram/g | Available | Manufacturing | 8/07/2025 |
sodium valproate | Injection, solution | 400 mg | Available | Manufacturing | 8/07/2025 |
estradiol~estradiol~norethisterone acetate | Drug delivery system, transdermal | .78 mg~.62 mg~2.7 mg | Unavailable | Manufacturing | 8/07/2025 |
levothyroxine sodium | Tablet | 75 microgram | Unavailable | Manufacturing | 8/07/2025 |
prazosin hydrochloride | Tablet, uncoated | 5.5 mg | Unavailable | Manufacturing | 8/07/2025 |
prucalopride succinate | Tablet, film coated | 2.642 mg | Unavailable | Transport / Logistic issues / Storage capacity issues | 7/07/2025 |
galantamine hydrobromide | Capsule, modified release | 20.504 mg | Unavailable | Manufacturing | 7/07/2025 |
galantamine hydrobromide | Capsule, modified release | 30.756 mg | Unavailable | Manufacturing | 7/07/2025 |
deoxycholic acid | Injection, solution | 10 mg/mL | Reduction in supply until supply is exhausted | Commercial Changes / Commercial viability | 7/07/2025 |
ezetimibe | Tablet, uncoated | 10 mg | Unavailable | Unexpected increase in consumer demand | 7/07/2025 |
nicorandil | Tablet, uncoated | 10 mg | Limited Availability | Manufacturing | 7/07/2025 |
nitisinone | Tablet | 10 mg | Unavailable | Manufacturing | 7/07/2025 |
nitisinone | Tablet | 5 mg | Limited Availability | Manufacturing | 7/07/2025 |
avatrombopag maleate | Tablet, film coated | 23.6 mg | Available | Manufacturing | 7/07/2025 |